Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia

Autores
Herrera, Maria Inés; Romero, Juan Ignacio; Rodríguez de Fonseca, Fernando; Blanco, Eduardo; Capani, Francisco
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Perinatal asphyxia (PA) is still a serious health problem associated with neuronal loss and morbidity. PA pathophysiology implies oxidative stress, cell damage and over activation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. Oleoylethanolamide (OEA), a cannabinoid agonist that exerts anti-inflammatory actions through PPAR activation, could be a possible target for neuroprotection. However, its role in perinatal hypoxic brain injury remains still unknown. In this study, we evaluated the behavioral consequences of OEA treatment in 30 days-old asphyctic rats. Results indicated that rats subjected to OEA administration showed an improvement in exploratory locomotion. This data suggests a possible neuroprotective role of OEA in severe perinatal asphyxia modifications.
Fil: Herrera, Maria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Rodríguez de Fonseca, Fernando. Instituto de Investigación Biomédica de Málaga; España
Fil: Blanco, Eduardo. Universidad de Málaga; España
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina. Universidad Argentina ; Argentina
Materia
Acetinolamidas
Perinatal asfixia
Neuroproteccion
Exploratory locomotion
Anti-inflammatory effect
Perinatal asphyxia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30896
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioral Effect of Oleoylethanolamide on Perinatal AsphyxiaHerrera, Maria InésRomero, Juan IgnacioRodríguez de Fonseca, FernandoBlanco, EduardoCapani, FranciscoAcetinolamidasPerinatal asfixiaNeuroproteccionExploratory locomotionAnti-inflammatory effectPerinatal asphyxiahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Perinatal asphyxia (PA) is still a serious health problem associated with neuronal loss and morbidity. PA pathophysiology implies oxidative stress, cell damage and over activation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. Oleoylethanolamide (OEA), a cannabinoid agonist that exerts anti-inflammatory actions through PPAR activation, could be a possible target for neuroprotection. However, its role in perinatal hypoxic brain injury remains still unknown. In this study, we evaluated the behavioral consequences of OEA treatment in 30 days-old asphyctic rats. Results indicated that rats subjected to OEA administration showed an improvement in exploratory locomotion. This data suggests a possible neuroprotective role of OEA in severe perinatal asphyxia modifications.Fil: Herrera, Maria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Rodríguez de Fonseca, Fernando. Instituto de Investigación Biomédica de Málaga; EspañaFil: Blanco, Eduardo. Universidad de Málaga; EspañaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina. Universidad Argentina ; ArgentinaCosmos Scholars2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30896Capani, Francisco; Blanco, Eduardo; Rodríguez de Fonseca, Fernando; Romero, Juan Ignacio; Herrera, Maria Inés; Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia; Cosmos Scholars; Journal of Advanced Neuroscience Research; 1; 1; 10-2014; 22-262409-3564CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cosmosscholars.com/previous-issue-janr/68-abstracts/janr/157-abstract-behavioral-effect-of-oleoylethanolamide-on-perinatal-asphyxiainfo:eu-repo/semantics/altIdentifier/doi/10.15379/2409-3564.2014.01.01.3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:28:30Zoai:ri.conicet.gov.ar:11336/30896instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:28:31.081CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
title Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
spellingShingle Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
Herrera, Maria Inés
Acetinolamidas
Perinatal asfixia
Neuroproteccion
Exploratory locomotion
Anti-inflammatory effect
Perinatal asphyxia
title_short Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
title_full Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
title_fullStr Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
title_full_unstemmed Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
title_sort Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
dc.creator.none.fl_str_mv Herrera, Maria Inés
Romero, Juan Ignacio
Rodríguez de Fonseca, Fernando
Blanco, Eduardo
Capani, Francisco
author Herrera, Maria Inés
author_facet Herrera, Maria Inés
Romero, Juan Ignacio
Rodríguez de Fonseca, Fernando
Blanco, Eduardo
Capani, Francisco
author_role author
author2 Romero, Juan Ignacio
Rodríguez de Fonseca, Fernando
Blanco, Eduardo
Capani, Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acetinolamidas
Perinatal asfixia
Neuroproteccion
Exploratory locomotion
Anti-inflammatory effect
Perinatal asphyxia
topic Acetinolamidas
Perinatal asfixia
Neuroproteccion
Exploratory locomotion
Anti-inflammatory effect
Perinatal asphyxia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Perinatal asphyxia (PA) is still a serious health problem associated with neuronal loss and morbidity. PA pathophysiology implies oxidative stress, cell damage and over activation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. Oleoylethanolamide (OEA), a cannabinoid agonist that exerts anti-inflammatory actions through PPAR activation, could be a possible target for neuroprotection. However, its role in perinatal hypoxic brain injury remains still unknown. In this study, we evaluated the behavioral consequences of OEA treatment in 30 days-old asphyctic rats. Results indicated that rats subjected to OEA administration showed an improvement in exploratory locomotion. This data suggests a possible neuroprotective role of OEA in severe perinatal asphyxia modifications.
Fil: Herrera, Maria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Rodríguez de Fonseca, Fernando. Instituto de Investigación Biomédica de Málaga; España
Fil: Blanco, Eduardo. Universidad de Málaga; España
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina. Universidad Argentina ; Argentina
description Perinatal asphyxia (PA) is still a serious health problem associated with neuronal loss and morbidity. PA pathophysiology implies oxidative stress, cell damage and over activation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. Oleoylethanolamide (OEA), a cannabinoid agonist that exerts anti-inflammatory actions through PPAR activation, could be a possible target for neuroprotection. However, its role in perinatal hypoxic brain injury remains still unknown. In this study, we evaluated the behavioral consequences of OEA treatment in 30 days-old asphyctic rats. Results indicated that rats subjected to OEA administration showed an improvement in exploratory locomotion. This data suggests a possible neuroprotective role of OEA in severe perinatal asphyxia modifications.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30896
Capani, Francisco; Blanco, Eduardo; Rodríguez de Fonseca, Fernando; Romero, Juan Ignacio; Herrera, Maria Inés; Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia; Cosmos Scholars; Journal of Advanced Neuroscience Research; 1; 1; 10-2014; 22-26
2409-3564
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30896
identifier_str_mv Capani, Francisco; Blanco, Eduardo; Rodríguez de Fonseca, Fernando; Romero, Juan Ignacio; Herrera, Maria Inés; Behavioral Effect of Oleoylethanolamide on Perinatal Asphyxia; Cosmos Scholars; Journal of Advanced Neuroscience Research; 1; 1; 10-2014; 22-26
2409-3564
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cosmosscholars.com/previous-issue-janr/68-abstracts/janr/157-abstract-behavioral-effect-of-oleoylethanolamide-on-perinatal-asphyxia
info:eu-repo/semantics/altIdentifier/doi/10.15379/2409-3564.2014.01.01.3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cosmos Scholars
publisher.none.fl_str_mv Cosmos Scholars
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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