7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection

Autores
Vecchione, María Belén; Laufer, Natalia Lorna; Sued, Omar Gustavo; Corti, Marcelo; Salomon, Horacio Eduardo; Quiroga, María Florencia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progression or progress to chronic infection. Risk of developing TB among human immunodeficiency virus (HIV)-coinfected patients (HIV-TB) is 20–30 times higher than those without HIV infection, and a synergistic interplay between these two pathogens accelerates the decline in immunological functions. TB treatment in HIV-TB coinfected persons is challenging and it has a prolonged duration, mainly due to the immune system failure to provide an adequate support for the therapy. Therefore, we aimed to study the role of the hormone 7-oxo-dehydroepiandrosterone (7-OD) as a modulator of anti-tuberculosis immune responses in the context of HIV-TB coinfection.
Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Sued, Omar Gustavo. Fundación Huésped; Argentina
Fil: Corti, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
HUMAN
INFECTIOUS IMMUNITY-BACTERIA
HORMONE MODULATORY MECHANISMS
CYTOKINES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/110666
Acceder
id CONICETDig_999eb516c580c50191f3e633b56c3c98
oai_identifier_str oai:ri.conicet.gov.ar:11336/110666
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfectionVecchione, María BelénLaufer, Natalia LornaSued, Omar GustavoCorti, MarceloSalomon, Horacio EduardoQuiroga, María FlorenciaHUMANINFECTIOUS IMMUNITY-BACTERIAHORMONE MODULATORY MECHANISMSCYTOKINEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progression or progress to chronic infection. Risk of developing TB among human immunodeficiency virus (HIV)-coinfected patients (HIV-TB) is 20–30 times higher than those without HIV infection, and a synergistic interplay between these two pathogens accelerates the decline in immunological functions. TB treatment in HIV-TB coinfected persons is challenging and it has a prolonged duration, mainly due to the immune system failure to provide an adequate support for the therapy. Therefore, we aimed to study the role of the hormone 7-oxo-dehydroepiandrosterone (7-OD) as a modulator of anti-tuberculosis immune responses in the context of HIV-TB coinfection.Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Sued, Omar Gustavo. Fundación Huésped; ArgentinaFil: Corti, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaBioMed Central2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/110666Vecchione, María Belén; Laufer, Natalia Lorna; Sued, Omar Gustavo; Corti, Marcelo; Salomon, Horacio Eduardo; et al.; 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection; BioMed Central; Journal Of Biomedical Science; 27; 1; 1-2020; 1-231423-0127CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-019-0604-zinfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12929-019-0604-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:10:17Zoai:ri.conicet.gov.ar:11336/110666instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:10:18.179CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
title 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
spellingShingle 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
Vecchione, María Belén
HUMAN
INFECTIOUS IMMUNITY-BACTERIA
HORMONE MODULATORY MECHANISMS
CYTOKINES
title_short 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
title_full 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
title_fullStr 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
title_full_unstemmed 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
title_sort 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
dc.creator.none.fl_str_mv Vecchione, María Belén
Laufer, Natalia Lorna
Sued, Omar Gustavo
Corti, Marcelo
Salomon, Horacio Eduardo
Quiroga, María Florencia
author Vecchione, María Belén
author_facet Vecchione, María Belén
Laufer, Natalia Lorna
Sued, Omar Gustavo
Corti, Marcelo
Salomon, Horacio Eduardo
Quiroga, María Florencia
author_role author
author2 Laufer, Natalia Lorna
Sued, Omar Gustavo
Corti, Marcelo
Salomon, Horacio Eduardo
Quiroga, María Florencia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HUMAN
INFECTIOUS IMMUNITY-BACTERIA
HORMONE MODULATORY MECHANISMS
CYTOKINES
topic HUMAN
INFECTIOUS IMMUNITY-BACTERIA
HORMONE MODULATORY MECHANISMS
CYTOKINES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progression or progress to chronic infection. Risk of developing TB among human immunodeficiency virus (HIV)-coinfected patients (HIV-TB) is 20–30 times higher than those without HIV infection, and a synergistic interplay between these two pathogens accelerates the decline in immunological functions. TB treatment in HIV-TB coinfected persons is challenging and it has a prolonged duration, mainly due to the immune system failure to provide an adequate support for the therapy. Therefore, we aimed to study the role of the hormone 7-oxo-dehydroepiandrosterone (7-OD) as a modulator of anti-tuberculosis immune responses in the context of HIV-TB coinfection.
Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Sued, Omar Gustavo. Fundación Huésped; Argentina
Fil: Corti, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progression or progress to chronic infection. Risk of developing TB among human immunodeficiency virus (HIV)-coinfected patients (HIV-TB) is 20–30 times higher than those without HIV infection, and a synergistic interplay between these two pathogens accelerates the decline in immunological functions. TB treatment in HIV-TB coinfected persons is challenging and it has a prolonged duration, mainly due to the immune system failure to provide an adequate support for the therapy. Therefore, we aimed to study the role of the hormone 7-oxo-dehydroepiandrosterone (7-OD) as a modulator of anti-tuberculosis immune responses in the context of HIV-TB coinfection.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/110666
Vecchione, María Belén; Laufer, Natalia Lorna; Sued, Omar Gustavo; Corti, Marcelo; Salomon, Horacio Eduardo; et al.; 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection; BioMed Central; Journal Of Biomedical Science; 27; 1; 1-2020; 1-23
1423-0127
CONICET Digital
CONICET
url http://hdl.handle.net/11336/110666
identifier_str_mv Vecchione, María Belén; Laufer, Natalia Lorna; Sued, Omar Gustavo; Corti, Marcelo; Salomon, Horacio Eduardo; et al.; 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection; BioMed Central; Journal Of Biomedical Science; 27; 1; 1-2020; 1-23
1423-0127
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-019-0604-z
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12929-019-0604-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782487265542144
score 12.982451

Publicaciones similares