Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis

Autores
Vecchione, María Belén; Barrios Payán, Jorge; Mata Espinosa, Dulce; Márquez Velasco, Ricardo; Marquina Castillo, Brenda; Giannone, Denise Anabella; Acevedo, Milagros Victoria; Quiroga, María Florencia; Hernández Pando, Rogelio
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anti-tuberculous therapy successfully eradicates the infection, but it is long-lasting and impose the use of multiple drugs. Therefore, it is required to develop additional immunotherapy approaches to protect and manage human tuberculosis. In this study, we examined the properties of 7-oxo- dehydroepiandrosterone (7-oxo-DHEA), a DHEA-derivative hormone, through both in vitro and in vivo settings for M. tuberculosis (Mtb) infection. Firstly, we observed that 7-oxo-DHEA exhibited a bacteriostatic effect over Mtb growth. Furthermore, in an in vitro model of infection, 7-oxo-DHEA improved the killing of Mtb by human and murine macrophages and reduced the levels of anti-inflammatory cytokines secretion. Remarkably, 7-oxo-DHEA treatment moderated Mtb growth and lung injury during the progressive phase of TB disease in mice. Our findings demonstrate that this compound enhances immune responses, resulting in a more favorable profile for mycobacteria control. Further investigations are required to explore the potential use of 7-oxo-DHEA as a novel adjunctive host-directed treatment in the context of pulmonary tuberculosis disease, constraining Mtb infection and preventing severe lung injury.
Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Barrios Payán, Jorge. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México
Fil: Mata Espinosa, Dulce. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México
Fil: Márquez Velasco, Ricardo. Instituto Nacional de Cardiología Ignacio Chávez; México
Fil: Marquina Castillo, Brenda. Instituto Nacional de Cardiología Ignacio Chávez; México
Fil: Giannone, Denise Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Acevedo, Milagros Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Hernández Pando, Rogelio. Instituto Nacional de Cardiología Ignacio Chávez; México
Materia
TUBERCULOSIS
7-OXO-DHEA
THERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266416
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/266416
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosisVecchione, María BelénBarrios Payán, JorgeMata Espinosa, DulceMárquez Velasco, RicardoMarquina Castillo, BrendaGiannone, Denise AnabellaAcevedo, Milagros VictoriaQuiroga, María FlorenciaHernández Pando, RogelioTUBERCULOSIS7-OXO-DHEATHERAPYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Anti-tuberculous therapy successfully eradicates the infection, but it is long-lasting and impose the use of multiple drugs. Therefore, it is required to develop additional immunotherapy approaches to protect and manage human tuberculosis. In this study, we examined the properties of 7-oxo- dehydroepiandrosterone (7-oxo-DHEA), a DHEA-derivative hormone, through both in vitro and in vivo settings for M. tuberculosis (Mtb) infection. Firstly, we observed that 7-oxo-DHEA exhibited a bacteriostatic effect over Mtb growth. Furthermore, in an in vitro model of infection, 7-oxo-DHEA improved the killing of Mtb by human and murine macrophages and reduced the levels of anti-inflammatory cytokines secretion. Remarkably, 7-oxo-DHEA treatment moderated Mtb growth and lung injury during the progressive phase of TB disease in mice. Our findings demonstrate that this compound enhances immune responses, resulting in a more favorable profile for mycobacteria control. Further investigations are required to explore the potential use of 7-oxo-DHEA as a novel adjunctive host-directed treatment in the context of pulmonary tuberculosis disease, constraining Mtb infection and preventing severe lung injury.Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Barrios Payán, Jorge. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; MéxicoFil: Mata Espinosa, Dulce. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; MéxicoFil: Márquez Velasco, Ricardo. Instituto Nacional de Cardiología Ignacio Chávez; MéxicoFil: Marquina Castillo, Brenda. Instituto Nacional de Cardiología Ignacio Chávez; MéxicoFil: Giannone, Denise Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Acevedo, Milagros Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Hernández Pando, Rogelio. Instituto Nacional de Cardiología Ignacio Chávez; MéxicoSpringer2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266416Vecchione, María Belén; Barrios Payán, Jorge; Mata Espinosa, Dulce; Márquez Velasco, Ricardo; Marquina Castillo, Brenda; et al.; Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis; Springer; Research Square; 7-2024; 1-222693-5015CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.researchsquare.com/article/rs-4601471/v1info:eu-repo/semantics/altIdentifier/doi/10.21203/rs.3.rs-4601471/v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:15Zoai:ri.conicet.gov.ar:11336/266416instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:15.875CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
title Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
spellingShingle Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
Vecchione, María Belén
TUBERCULOSIS
7-OXO-DHEA
THERAPY
title_short Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
title_full Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
title_fullStr Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
title_full_unstemmed Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
title_sort Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
dc.creator.none.fl_str_mv Vecchione, María Belén
Barrios Payán, Jorge
Mata Espinosa, Dulce
Márquez Velasco, Ricardo
Marquina Castillo, Brenda
Giannone, Denise Anabella
Acevedo, Milagros Victoria
Quiroga, María Florencia
Hernández Pando, Rogelio
author Vecchione, María Belén
author_facet Vecchione, María Belén
Barrios Payán, Jorge
Mata Espinosa, Dulce
Márquez Velasco, Ricardo
Marquina Castillo, Brenda
Giannone, Denise Anabella
Acevedo, Milagros Victoria
Quiroga, María Florencia
Hernández Pando, Rogelio
author_role author
author2 Barrios Payán, Jorge
Mata Espinosa, Dulce
Márquez Velasco, Ricardo
Marquina Castillo, Brenda
Giannone, Denise Anabella
Acevedo, Milagros Victoria
Quiroga, María Florencia
Hernández Pando, Rogelio
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TUBERCULOSIS
7-OXO-DHEA
THERAPY
topic TUBERCULOSIS
7-OXO-DHEA
THERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Anti-tuberculous therapy successfully eradicates the infection, but it is long-lasting and impose the use of multiple drugs. Therefore, it is required to develop additional immunotherapy approaches to protect and manage human tuberculosis. In this study, we examined the properties of 7-oxo- dehydroepiandrosterone (7-oxo-DHEA), a DHEA-derivative hormone, through both in vitro and in vivo settings for M. tuberculosis (Mtb) infection. Firstly, we observed that 7-oxo-DHEA exhibited a bacteriostatic effect over Mtb growth. Furthermore, in an in vitro model of infection, 7-oxo-DHEA improved the killing of Mtb by human and murine macrophages and reduced the levels of anti-inflammatory cytokines secretion. Remarkably, 7-oxo-DHEA treatment moderated Mtb growth and lung injury during the progressive phase of TB disease in mice. Our findings demonstrate that this compound enhances immune responses, resulting in a more favorable profile for mycobacteria control. Further investigations are required to explore the potential use of 7-oxo-DHEA as a novel adjunctive host-directed treatment in the context of pulmonary tuberculosis disease, constraining Mtb infection and preventing severe lung injury.
Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Barrios Payán, Jorge. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México
Fil: Mata Espinosa, Dulce. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México
Fil: Márquez Velasco, Ricardo. Instituto Nacional de Cardiología Ignacio Chávez; México
Fil: Marquina Castillo, Brenda. Instituto Nacional de Cardiología Ignacio Chávez; México
Fil: Giannone, Denise Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Acevedo, Milagros Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Hernández Pando, Rogelio. Instituto Nacional de Cardiología Ignacio Chávez; México
description Anti-tuberculous therapy successfully eradicates the infection, but it is long-lasting and impose the use of multiple drugs. Therefore, it is required to develop additional immunotherapy approaches to protect and manage human tuberculosis. In this study, we examined the properties of 7-oxo- dehydroepiandrosterone (7-oxo-DHEA), a DHEA-derivative hormone, through both in vitro and in vivo settings for M. tuberculosis (Mtb) infection. Firstly, we observed that 7-oxo-DHEA exhibited a bacteriostatic effect over Mtb growth. Furthermore, in an in vitro model of infection, 7-oxo-DHEA improved the killing of Mtb by human and murine macrophages and reduced the levels of anti-inflammatory cytokines secretion. Remarkably, 7-oxo-DHEA treatment moderated Mtb growth and lung injury during the progressive phase of TB disease in mice. Our findings demonstrate that this compound enhances immune responses, resulting in a more favorable profile for mycobacteria control. Further investigations are required to explore the potential use of 7-oxo-DHEA as a novel adjunctive host-directed treatment in the context of pulmonary tuberculosis disease, constraining Mtb infection and preventing severe lung injury.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266416
Vecchione, María Belén; Barrios Payán, Jorge; Mata Espinosa, Dulce; Márquez Velasco, Ricardo; Marquina Castillo, Brenda; et al.; Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis; Springer; Research Square; 7-2024; 1-22
2693-5015
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266416
identifier_str_mv Vecchione, María Belén; Barrios Payán, Jorge; Mata Espinosa, Dulce; Márquez Velasco, Ricardo; Marquina Castillo, Brenda; et al.; Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis; Springer; Research Square; 7-2024; 1-22
2693-5015
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.researchsquare.com/article/rs-4601471/v1
info:eu-repo/semantics/altIdentifier/doi/10.21203/rs.3.rs-4601471/v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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