The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity

Autores
Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; Hu, Donglei; Huntsman, Scott; Eng, Celeste; Licona Limón, Paula; Weinstein, Jason S.; De Broski, Herbert R.; Craft , Joseph E.; Flavell, Richard A.; Repetto, Silvia; Correale, Jorge; Burchard, Esteban G.; Torgerson, Dora G.; Ghosh, Sourav; Rothlin, Carla V.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.
Fil: Chan, Pamela Y.. University of Yale. School of Medicine; Estados Unidos
Fil: Carrera Silva, Eugenio Antonio. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: De Kouchkovsky, Dimitri. University of Yale. School of Medicine; Estados Unidos
Fil: Joannas, Leonel D.. University of Yale. School of Medicine; Estados Unidos
Fil: Hao, Liming. University of Yale. School of Medicine; Estados Unidos
Fil: Hu, Donglei. University of California; Estados Unidos
Fil: Huntsman, Scott. University of California; Estados Unidos
Fil: Eng, Celeste. University of California; Estados Unidos
Fil: Licona Limón, Paula. University of Yale. School of Medicine; Estados Unidos
Fil: Weinstein, Jason S.. University of Yale. School of Medicine; Estados Unidos
Fil: De Broski, Herbert R.. University of California; Estados Unidos
Fil: Craft , Joseph E.. University of Yale. School of Medicine; Estados Unidos
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
Fil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina
Fil: Burchard, Esteban G.. University of California; Estados Unidos
Fil: Torgerson, Dora G.. University of California; Estados Unidos
Fil: Ghosh, Sourav. University of Yale. School of Medicine; Estados Unidos
Fil: Rothlin, Carla V.. University of Yale. School of Medicine; Estados Unidos
Materia
Tam Family
Tyro 3
Type 2 Immunity
Blood Proteins
Interleukin 4
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/45316

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oai_identifier_str oai:ri.conicet.gov.ar:11336/45316
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunityChan, Pamela Y.Carrera Silva, Eugenio AntonioDe Kouchkovsky, DimitriJoannas, Leonel D.Hao, LimingHu, DongleiHuntsman, ScottEng, CelesteLicona Limón, PaulaWeinstein, Jason S.De Broski, Herbert R.Craft , Joseph E.Flavell, Richard A.Repetto, SilviaCorreale, JorgeBurchard, Esteban G.Torgerson, Dora G.Ghosh, SouravRothlin, Carla V.Tam FamilyTyro 3Type 2 ImmunityBlood ProteinsInterleukin 4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.Fil: Chan, Pamela Y.. University of Yale. School of Medicine; Estados UnidosFil: Carrera Silva, Eugenio Antonio. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: De Kouchkovsky, Dimitri. University of Yale. School of Medicine; Estados UnidosFil: Joannas, Leonel D.. University of Yale. School of Medicine; Estados UnidosFil: Hao, Liming. University of Yale. School of Medicine; Estados UnidosFil: Hu, Donglei. University of California; Estados UnidosFil: Huntsman, Scott. University of California; Estados UnidosFil: Eng, Celeste. University of California; Estados UnidosFil: Licona Limón, Paula. University of Yale. School of Medicine; Estados UnidosFil: Weinstein, Jason S.. University of Yale. School of Medicine; Estados UnidosFil: De Broski, Herbert R.. University of California; Estados UnidosFil: Craft , Joseph E.. University of Yale. School of Medicine; Estados UnidosFil: Flavell, Richard A.. University of Yale. School of Medicine; Estados UnidosFil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; ArgentinaFil: Burchard, Esteban G.. University of California; Estados UnidosFil: Torgerson, Dora G.. University of California; Estados UnidosFil: Ghosh, Sourav. University of Yale. School of Medicine; Estados UnidosFil: Rothlin, Carla V.. University of Yale. School of Medicine; Estados UnidosAmerican Association for the Advancement of Science2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/45316Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-1030036-80751095-9203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/352/6281/99.longinfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.aaf1358info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935984/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:54Zoai:ri.conicet.gov.ar:11336/45316instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:54.567CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
title The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
spellingShingle The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Chan, Pamela Y.
Tam Family
Tyro 3
Type 2 Immunity
Blood Proteins
Interleukin 4
title_short The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
title_full The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
title_fullStr The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
title_full_unstemmed The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
title_sort The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
dc.creator.none.fl_str_mv Chan, Pamela Y.
Carrera Silva, Eugenio Antonio
De Kouchkovsky, Dimitri
Joannas, Leonel D.
Hao, Liming
Hu, Donglei
Huntsman, Scott
Eng, Celeste
Licona Limón, Paula
Weinstein, Jason S.
De Broski, Herbert R.
Craft , Joseph E.
Flavell, Richard A.
Repetto, Silvia
Correale, Jorge
Burchard, Esteban G.
Torgerson, Dora G.
Ghosh, Sourav
Rothlin, Carla V.
author Chan, Pamela Y.
author_facet Chan, Pamela Y.
Carrera Silva, Eugenio Antonio
De Kouchkovsky, Dimitri
Joannas, Leonel D.
Hao, Liming
Hu, Donglei
Huntsman, Scott
Eng, Celeste
Licona Limón, Paula
Weinstein, Jason S.
De Broski, Herbert R.
Craft , Joseph E.
Flavell, Richard A.
Repetto, Silvia
Correale, Jorge
Burchard, Esteban G.
Torgerson, Dora G.
Ghosh, Sourav
Rothlin, Carla V.
author_role author
author2 Carrera Silva, Eugenio Antonio
De Kouchkovsky, Dimitri
Joannas, Leonel D.
Hao, Liming
Hu, Donglei
Huntsman, Scott
Eng, Celeste
Licona Limón, Paula
Weinstein, Jason S.
De Broski, Herbert R.
Craft , Joseph E.
Flavell, Richard A.
Repetto, Silvia
Correale, Jorge
Burchard, Esteban G.
Torgerson, Dora G.
Ghosh, Sourav
Rothlin, Carla V.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tam Family
Tyro 3
Type 2 Immunity
Blood Proteins
Interleukin 4
topic Tam Family
Tyro 3
Type 2 Immunity
Blood Proteins
Interleukin 4
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.
Fil: Chan, Pamela Y.. University of Yale. School of Medicine; Estados Unidos
Fil: Carrera Silva, Eugenio Antonio. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: De Kouchkovsky, Dimitri. University of Yale. School of Medicine; Estados Unidos
Fil: Joannas, Leonel D.. University of Yale. School of Medicine; Estados Unidos
Fil: Hao, Liming. University of Yale. School of Medicine; Estados Unidos
Fil: Hu, Donglei. University of California; Estados Unidos
Fil: Huntsman, Scott. University of California; Estados Unidos
Fil: Eng, Celeste. University of California; Estados Unidos
Fil: Licona Limón, Paula. University of Yale. School of Medicine; Estados Unidos
Fil: Weinstein, Jason S.. University of Yale. School of Medicine; Estados Unidos
Fil: De Broski, Herbert R.. University of California; Estados Unidos
Fil: Craft , Joseph E.. University of Yale. School of Medicine; Estados Unidos
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
Fil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina
Fil: Burchard, Esteban G.. University of California; Estados Unidos
Fil: Torgerson, Dora G.. University of California; Estados Unidos
Fil: Ghosh, Sourav. University of Yale. School of Medicine; Estados Unidos
Fil: Rothlin, Carla V.. University of Yale. School of Medicine; Estados Unidos
description Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/45316
Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-103
0036-8075
1095-9203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/45316
identifier_str_mv Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-103
0036-8075
1095-9203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/352/6281/99.long
info:eu-repo/semantics/altIdentifier/doi/10.1126/science.aaf1358
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935984/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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