The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
- Autores
- Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; Hu, Donglei; Huntsman, Scott; Eng, Celeste; Licona Limón, Paula; Weinstein, Jason S.; De Broski, Herbert R.; Craft , Joseph E.; Flavell, Richard A.; Repetto, Silvia; Correale, Jorge; Burchard, Esteban G.; Torgerson, Dora G.; Ghosh, Sourav; Rothlin, Carla V.
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.
Fil: Chan, Pamela Y.. University of Yale. School of Medicine; Estados Unidos
Fil: Carrera Silva, Eugenio Antonio. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: De Kouchkovsky, Dimitri. University of Yale. School of Medicine; Estados Unidos
Fil: Joannas, Leonel D.. University of Yale. School of Medicine; Estados Unidos
Fil: Hao, Liming. University of Yale. School of Medicine; Estados Unidos
Fil: Hu, Donglei. University of California; Estados Unidos
Fil: Huntsman, Scott. University of California; Estados Unidos
Fil: Eng, Celeste. University of California; Estados Unidos
Fil: Licona Limón, Paula. University of Yale. School of Medicine; Estados Unidos
Fil: Weinstein, Jason S.. University of Yale. School of Medicine; Estados Unidos
Fil: De Broski, Herbert R.. University of California; Estados Unidos
Fil: Craft , Joseph E.. University of Yale. School of Medicine; Estados Unidos
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
Fil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina
Fil: Burchard, Esteban G.. University of California; Estados Unidos
Fil: Torgerson, Dora G.. University of California; Estados Unidos
Fil: Ghosh, Sourav. University of Yale. School of Medicine; Estados Unidos
Fil: Rothlin, Carla V.. University of Yale. School of Medicine; Estados Unidos - Materia
-
Tam Family
Tyro 3
Type 2 Immunity
Blood Proteins
Interleukin 4 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/45316
Ver los metadatos del registro completo
id |
CONICETDig_9977b51169abf3555ab20036a494ad87 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/45316 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunityChan, Pamela Y.Carrera Silva, Eugenio AntonioDe Kouchkovsky, DimitriJoannas, Leonel D.Hao, LimingHu, DongleiHuntsman, ScottEng, CelesteLicona Limón, PaulaWeinstein, Jason S.De Broski, Herbert R.Craft , Joseph E.Flavell, Richard A.Repetto, SilviaCorreale, JorgeBurchard, Esteban G.Torgerson, Dora G.Ghosh, SouravRothlin, Carla V.Tam FamilyTyro 3Type 2 ImmunityBlood ProteinsInterleukin 4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses.Fil: Chan, Pamela Y.. University of Yale. School of Medicine; Estados UnidosFil: Carrera Silva, Eugenio Antonio. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: De Kouchkovsky, Dimitri. University of Yale. School of Medicine; Estados UnidosFil: Joannas, Leonel D.. University of Yale. School of Medicine; Estados UnidosFil: Hao, Liming. University of Yale. School of Medicine; Estados UnidosFil: Hu, Donglei. University of California; Estados UnidosFil: Huntsman, Scott. University of California; Estados UnidosFil: Eng, Celeste. University of California; Estados UnidosFil: Licona Limón, Paula. University of Yale. School of Medicine; Estados UnidosFil: Weinstein, Jason S.. University of Yale. School of Medicine; Estados UnidosFil: De Broski, Herbert R.. University of California; Estados UnidosFil: Craft , Joseph E.. University of Yale. School of Medicine; Estados UnidosFil: Flavell, Richard A.. University of Yale. School of Medicine; Estados UnidosFil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; ArgentinaFil: Burchard, Esteban G.. University of California; Estados UnidosFil: Torgerson, Dora G.. University of California; Estados UnidosFil: Ghosh, Sourav. University of Yale. School of Medicine; Estados UnidosFil: Rothlin, Carla V.. University of Yale. School of Medicine; Estados UnidosAmerican Association for the Advancement of Science2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/45316Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-1030036-80751095-9203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/352/6281/99.longinfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.aaf1358info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935984/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:54Zoai:ri.conicet.gov.ar:11336/45316instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:54.567CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
title |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
spellingShingle |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity Chan, Pamela Y. Tam Family Tyro 3 Type 2 Immunity Blood Proteins Interleukin 4 |
title_short |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
title_full |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
title_fullStr |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
title_full_unstemmed |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
title_sort |
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity |
dc.creator.none.fl_str_mv |
Chan, Pamela Y. Carrera Silva, Eugenio Antonio De Kouchkovsky, Dimitri Joannas, Leonel D. Hao, Liming Hu, Donglei Huntsman, Scott Eng, Celeste Licona Limón, Paula Weinstein, Jason S. De Broski, Herbert R. Craft , Joseph E. Flavell, Richard A. Repetto, Silvia Correale, Jorge Burchard, Esteban G. Torgerson, Dora G. Ghosh, Sourav Rothlin, Carla V. |
author |
Chan, Pamela Y. |
author_facet |
Chan, Pamela Y. Carrera Silva, Eugenio Antonio De Kouchkovsky, Dimitri Joannas, Leonel D. Hao, Liming Hu, Donglei Huntsman, Scott Eng, Celeste Licona Limón, Paula Weinstein, Jason S. De Broski, Herbert R. Craft , Joseph E. Flavell, Richard A. Repetto, Silvia Correale, Jorge Burchard, Esteban G. Torgerson, Dora G. Ghosh, Sourav Rothlin, Carla V. |
author_role |
author |
author2 |
Carrera Silva, Eugenio Antonio De Kouchkovsky, Dimitri Joannas, Leonel D. Hao, Liming Hu, Donglei Huntsman, Scott Eng, Celeste Licona Limón, Paula Weinstein, Jason S. De Broski, Herbert R. Craft , Joseph E. Flavell, Richard A. Repetto, Silvia Correale, Jorge Burchard, Esteban G. Torgerson, Dora G. Ghosh, Sourav Rothlin, Carla V. |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Tam Family Tyro 3 Type 2 Immunity Blood Proteins Interleukin 4 |
topic |
Tam Family Tyro 3 Type 2 Immunity Blood Proteins Interleukin 4 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses. Fil: Chan, Pamela Y.. University of Yale. School of Medicine; Estados Unidos Fil: Carrera Silva, Eugenio Antonio. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: De Kouchkovsky, Dimitri. University of Yale. School of Medicine; Estados Unidos Fil: Joannas, Leonel D.. University of Yale. School of Medicine; Estados Unidos Fil: Hao, Liming. University of Yale. School of Medicine; Estados Unidos Fil: Hu, Donglei. University of California; Estados Unidos Fil: Huntsman, Scott. University of California; Estados Unidos Fil: Eng, Celeste. University of California; Estados Unidos Fil: Licona Limón, Paula. University of Yale. School of Medicine; Estados Unidos Fil: Weinstein, Jason S.. University of Yale. School of Medicine; Estados Unidos Fil: De Broski, Herbert R.. University of California; Estados Unidos Fil: Craft , Joseph E.. University of Yale. School of Medicine; Estados Unidos Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos Fil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas ; Argentina Fil: Burchard, Esteban G.. University of California; Estados Unidos Fil: Torgerson, Dora G.. University of California; Estados Unidos Fil: Ghosh, Sourav. University of Yale. School of Medicine; Estados Unidos Fil: Rothlin, Carla V.. University of Yale. School of Medicine; Estados Unidos |
description |
Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/45316 Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-103 0036-8075 1095-9203 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/45316 |
identifier_str_mv |
Chan, Pamela Y.; Carrera Silva, Eugenio Antonio; De Kouchkovsky, Dimitri; Joannas, Leonel D.; Hao, Liming; et al.; The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity; American Association for the Advancement of Science; Science; 352; 6281; 4-2016; 99-103 0036-8075 1095-9203 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/352/6281/99.long info:eu-repo/semantics/altIdentifier/doi/10.1126/science.aaf1358 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935984/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
publisher.none.fl_str_mv |
American Association for the Advancement of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614318181580800 |
score |
13.070432 |