TAM receptor signaling in immune homeostasis
- Autores
- Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
Fil: Rothlin, Carla. University of Yale; Estados Unidos
Fil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bosurgi, Lidia. University of Yale; Estados Unidos
Fil: Ghosh, Sourav. University of Yale; Estados Unidos - Materia
-
AXL
GAS6
MERTK
PROS1
TYRO3 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/38207
Ver los metadatos del registro completo
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TAM receptor signaling in immune homeostasisRothlin, CarlaCarrera Silva, Eugenio AntonioBosurgi, LidiaGhosh, SouravAXLGAS6MERTKPROS1TYRO3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.Fil: Rothlin, Carla. University of Yale; Estados UnidosFil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bosurgi, Lidia. University of Yale; Estados UnidosFil: Ghosh, Sourav. University of Yale; Estados UnidosAnnual Reviews2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38207Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav; TAM receptor signaling in immune homeostasis; Annual Reviews; Annual Review Of Immunology; 33; 3-2015; 355-3910732-0582CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.annualreviews.org/doi/full/10.1146/annurev-immunol-032414-112103?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmedinfo:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-immunol-032414-112103info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491918/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:09Zoai:ri.conicet.gov.ar:11336/38207instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:09.735CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
TAM receptor signaling in immune homeostasis |
title |
TAM receptor signaling in immune homeostasis |
spellingShingle |
TAM receptor signaling in immune homeostasis Rothlin, Carla AXL GAS6 MERTK PROS1 TYRO3 |
title_short |
TAM receptor signaling in immune homeostasis |
title_full |
TAM receptor signaling in immune homeostasis |
title_fullStr |
TAM receptor signaling in immune homeostasis |
title_full_unstemmed |
TAM receptor signaling in immune homeostasis |
title_sort |
TAM receptor signaling in immune homeostasis |
dc.creator.none.fl_str_mv |
Rothlin, Carla Carrera Silva, Eugenio Antonio Bosurgi, Lidia Ghosh, Sourav |
author |
Rothlin, Carla |
author_facet |
Rothlin, Carla Carrera Silva, Eugenio Antonio Bosurgi, Lidia Ghosh, Sourav |
author_role |
author |
author2 |
Carrera Silva, Eugenio Antonio Bosurgi, Lidia Ghosh, Sourav |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
AXL GAS6 MERTK PROS1 TYRO3 |
topic |
AXL GAS6 MERTK PROS1 TYRO3 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease. Fil: Rothlin, Carla. University of Yale; Estados Unidos Fil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bosurgi, Lidia. University of Yale; Estados Unidos Fil: Ghosh, Sourav. University of Yale; Estados Unidos |
description |
The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/38207 Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav; TAM receptor signaling in immune homeostasis; Annual Reviews; Annual Review Of Immunology; 33; 3-2015; 355-391 0732-0582 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/38207 |
identifier_str_mv |
Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav; TAM receptor signaling in immune homeostasis; Annual Reviews; Annual Review Of Immunology; 33; 3-2015; 355-391 0732-0582 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.annualreviews.org/doi/full/10.1146/annurev-immunol-032414-112103?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed info:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-immunol-032414-112103 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491918/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Annual Reviews |
publisher.none.fl_str_mv |
Annual Reviews |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614416223436800 |
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13.070432 |