TAM receptor signaling in immune homeostasis

Autores
Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
Fil: Rothlin, Carla. University of Yale; Estados Unidos
Fil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bosurgi, Lidia. University of Yale; Estados Unidos
Fil: Ghosh, Sourav. University of Yale; Estados Unidos
Materia
AXL
GAS6
MERTK
PROS1
TYRO3
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38207
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38207
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling TAM receptor signaling in immune homeostasisRothlin, CarlaCarrera Silva, Eugenio AntonioBosurgi, LidiaGhosh, SouravAXLGAS6MERTKPROS1TYRO3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.Fil: Rothlin, Carla. University of Yale; Estados UnidosFil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bosurgi, Lidia. University of Yale; Estados UnidosFil: Ghosh, Sourav. University of Yale; Estados UnidosAnnual Reviews2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38207Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav; TAM receptor signaling in immune homeostasis; Annual Reviews; Annual Review Of Immunology; 33; 3-2015; 355-3910732-0582CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.annualreviews.org/doi/full/10.1146/annurev-immunol-032414-112103?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmedinfo:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-immunol-032414-112103info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491918/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:11:24Zoai:ri.conicet.gov.ar:11336/38207instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:11:25.108CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv TAM receptor signaling in immune homeostasis
title TAM receptor signaling in immune homeostasis
spellingShingle TAM receptor signaling in immune homeostasis
Rothlin, Carla
AXL
GAS6
MERTK
PROS1
TYRO3
title_short TAM receptor signaling in immune homeostasis
title_full TAM receptor signaling in immune homeostasis
title_fullStr TAM receptor signaling in immune homeostasis
title_full_unstemmed TAM receptor signaling in immune homeostasis
title_sort TAM receptor signaling in immune homeostasis
dc.creator.none.fl_str_mv Rothlin, Carla
Carrera Silva, Eugenio Antonio
Bosurgi, Lidia
Ghosh, Sourav
author Rothlin, Carla
author_facet Rothlin, Carla
Carrera Silva, Eugenio Antonio
Bosurgi, Lidia
Ghosh, Sourav
author_role author
author2 Carrera Silva, Eugenio Antonio
Bosurgi, Lidia
Ghosh, Sourav
author2_role author
author
author
dc.subject.none.fl_str_mv AXL
GAS6
MERTK
PROS1
TYRO3
topic AXL
GAS6
MERTK
PROS1
TYRO3
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
Fil: Rothlin, Carla. University of Yale; Estados Unidos
Fil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bosurgi, Lidia. University of Yale; Estados Unidos
Fil: Ghosh, Sourav. University of Yale; Estados Unidos
description The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38207
Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav; TAM receptor signaling in immune homeostasis; Annual Reviews; Annual Review Of Immunology; 33; 3-2015; 355-391
0732-0582
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38207
identifier_str_mv Rothlin, Carla; Carrera Silva, Eugenio Antonio; Bosurgi, Lidia; Ghosh, Sourav; TAM receptor signaling in immune homeostasis; Annual Reviews; Annual Review Of Immunology; 33; 3-2015; 355-391
0732-0582
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.annualreviews.org/doi/full/10.1146/annurev-immunol-032414-112103?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
info:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-immunol-032414-112103
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491918/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Annual Reviews
publisher.none.fl_str_mv Annual Reviews
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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