An essential role for decorin in bladder cancer invasiveness

Autores
El Behi, Mohamed; Krumeich, Sophie; Lodillinsky, Catalina; Kamoun, Aurélie; Tibaldi, Lorenzo; Sugano, Gaël; de Reynies, Aurélien; Chapeaublanc, Elodie; Laplanche, Agnès; Lebret, Thierry; Allory, Yves; Radvanyi, François; Lantz, Olivier; Eijan, Ana Maria; Bernard Pierrot, Isabelle; Théery, Clotilde
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours.
Fil: El Behi, Mohamed. Institute Curie; Francia. Centre de Recherche de I; Francia. Inserm; Francia
Fil: Krumeich, Sophie. Institute Curie; Francia. Inserm; Francia
Fil: Lodillinsky, Catalina. Institute Curie; Francia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kamoun, Aurélie. Institute Curie; Francia
Fil: Tibaldi, Lorenzo. Institute Curie; Francia. Inserm; Francia
Fil: Sugano, Gaël. Institute Curie; Francia. Inserm; Francia
Fil: de Reynies, Aurélien. Ligue Nationale Contre le Cancer; Francia
Fil: Chapeaublanc, Elodie. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Laplanche, Agnès. Centre National de la Recherche Scientifique; Francia. Institut de Cancérologie Gustave Roussy; Francia
Fil: Lebret, Thierry. Hôpital Foch. Service d; Francia. Université de Versailles; Francia
Fil: Allory, Yves. Inserm; Francia
Fil: Radvanyi, François. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Lantz, Olivier. Institute Curie; Francia. Inserm; Francia
Fil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernard Pierrot, Isabelle. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Théery, Clotilde. Institute Curie; Francia. Inserm; Francia
Materia
Angiogenesis
Bladder cancer
Decorin
Tumor inmunity
Tumor microenvironment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15921
Acceder
id CONICETDig_98f47687143e39a9202abc4b3685d965
oai_identifier_str oai:ri.conicet.gov.ar:11336/15921
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An essential role for decorin in bladder cancer invasivenessEl Behi, MohamedKrumeich, SophieLodillinsky, CatalinaKamoun, AurélieTibaldi, LorenzoSugano, Gaëlde Reynies, AurélienChapeaublanc, ElodieLaplanche, AgnèsLebret, ThierryAllory, YvesRadvanyi, FrançoisLantz, OlivierEijan, Ana MariaBernard Pierrot, IsabelleThéery, ClotildeAngiogenesisBladder cancerDecorinTumor inmunityTumor microenvironmenthttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours.Fil: El Behi, Mohamed. Institute Curie; Francia. Centre de Recherche de I; Francia. Inserm; FranciaFil: Krumeich, Sophie. Institute Curie; Francia. Inserm; FranciaFil: Lodillinsky, Catalina. Institute Curie; Francia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kamoun, Aurélie. Institute Curie; FranciaFil: Tibaldi, Lorenzo. Institute Curie; Francia. Inserm; FranciaFil: Sugano, Gaël. Institute Curie; Francia. Inserm; FranciaFil: de Reynies, Aurélien. Ligue Nationale Contre le Cancer; FranciaFil: Chapeaublanc, Elodie. Institute Curie; Francia. Centre National de la Recherche Scientifique; FranciaFil: Laplanche, Agnès. Centre National de la Recherche Scientifique; Francia. Institut de Cancérologie Gustave Roussy; FranciaFil: Lebret, Thierry. Hôpital Foch. Service d; Francia. Université de Versailles; FranciaFil: Allory, Yves. Inserm; FranciaFil: Radvanyi, François. Institute Curie; Francia. Centre National de la Recherche Scientifique; FranciaFil: Lantz, Olivier. Institute Curie; Francia. Inserm; FranciaFil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bernard Pierrot, Isabelle. Institute Curie; Francia. Centre National de la Recherche Scientifique; FranciaFil: Théery, Clotilde. Institute Curie; Francia. Inserm; FranciaWiley2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15921El Behi, Mohamed; Krumeich, Sophie; Lodillinsky, Catalina; Kamoun, Aurélie; Tibaldi, Lorenzo; et al.; An essential role for decorin in bladder cancer invasiveness; Wiley; Embo Molecular Medicine; 5; 12; 12-2013; 1835-18511757-46761757-4684enginfo:eu-repo/semantics/altIdentifier/url/http://embomolmed.embopress.org/content/5/12/1835info:eu-repo/semantics/altIdentifier/doi/10.1002/emmm.201302655info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914526/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:53:40Zoai:ri.conicet.gov.ar:11336/15921instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:53:40.439CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An essential role for decorin in bladder cancer invasiveness
title An essential role for decorin in bladder cancer invasiveness
spellingShingle An essential role for decorin in bladder cancer invasiveness
El Behi, Mohamed
Angiogenesis
Bladder cancer
Decorin
Tumor inmunity
Tumor microenvironment
title_short An essential role for decorin in bladder cancer invasiveness
title_full An essential role for decorin in bladder cancer invasiveness
title_fullStr An essential role for decorin in bladder cancer invasiveness
title_full_unstemmed An essential role for decorin in bladder cancer invasiveness
title_sort An essential role for decorin in bladder cancer invasiveness
dc.creator.none.fl_str_mv El Behi, Mohamed
Krumeich, Sophie
Lodillinsky, Catalina
Kamoun, Aurélie
Tibaldi, Lorenzo
Sugano, Gaël
de Reynies, Aurélien
Chapeaublanc, Elodie
Laplanche, Agnès
Lebret, Thierry
Allory, Yves
Radvanyi, François
Lantz, Olivier
Eijan, Ana Maria
Bernard Pierrot, Isabelle
Théery, Clotilde
author El Behi, Mohamed
author_facet El Behi, Mohamed
Krumeich, Sophie
Lodillinsky, Catalina
Kamoun, Aurélie
Tibaldi, Lorenzo
Sugano, Gaël
de Reynies, Aurélien
Chapeaublanc, Elodie
Laplanche, Agnès
Lebret, Thierry
Allory, Yves
Radvanyi, François
Lantz, Olivier
Eijan, Ana Maria
Bernard Pierrot, Isabelle
Théery, Clotilde
author_role author
author2 Krumeich, Sophie
Lodillinsky, Catalina
Kamoun, Aurélie
Tibaldi, Lorenzo
Sugano, Gaël
de Reynies, Aurélien
Chapeaublanc, Elodie
Laplanche, Agnès
Lebret, Thierry
Allory, Yves
Radvanyi, François
Lantz, Olivier
Eijan, Ana Maria
Bernard Pierrot, Isabelle
Théery, Clotilde
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiogenesis
Bladder cancer
Decorin
Tumor inmunity
Tumor microenvironment
topic Angiogenesis
Bladder cancer
Decorin
Tumor inmunity
Tumor microenvironment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours.
Fil: El Behi, Mohamed. Institute Curie; Francia. Centre de Recherche de I; Francia. Inserm; Francia
Fil: Krumeich, Sophie. Institute Curie; Francia. Inserm; Francia
Fil: Lodillinsky, Catalina. Institute Curie; Francia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kamoun, Aurélie. Institute Curie; Francia
Fil: Tibaldi, Lorenzo. Institute Curie; Francia. Inserm; Francia
Fil: Sugano, Gaël. Institute Curie; Francia. Inserm; Francia
Fil: de Reynies, Aurélien. Ligue Nationale Contre le Cancer; Francia
Fil: Chapeaublanc, Elodie. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Laplanche, Agnès. Centre National de la Recherche Scientifique; Francia. Institut de Cancérologie Gustave Roussy; Francia
Fil: Lebret, Thierry. Hôpital Foch. Service d; Francia. Université de Versailles; Francia
Fil: Allory, Yves. Inserm; Francia
Fil: Radvanyi, François. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Lantz, Olivier. Institute Curie; Francia. Inserm; Francia
Fil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernard Pierrot, Isabelle. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Théery, Clotilde. Institute Curie; Francia. Inserm; Francia
description Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15921
El Behi, Mohamed; Krumeich, Sophie; Lodillinsky, Catalina; Kamoun, Aurélie; Tibaldi, Lorenzo; et al.; An essential role for decorin in bladder cancer invasiveness; Wiley; Embo Molecular Medicine; 5; 12; 12-2013; 1835-1851
1757-4676
1757-4684
url http://hdl.handle.net/11336/15921
identifier_str_mv El Behi, Mohamed; Krumeich, Sophie; Lodillinsky, Catalina; Kamoun, Aurélie; Tibaldi, Lorenzo; et al.; An essential role for decorin in bladder cancer invasiveness; Wiley; Embo Molecular Medicine; 5; 12; 12-2013; 1835-1851
1757-4676
1757-4684
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://embomolmed.embopress.org/content/5/12/1835
info:eu-repo/semantics/altIdentifier/doi/10.1002/emmm.201302655
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914526/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.10058

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