Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer

Autores
Vera, Renzo; Lamberti, María Julia; Gonzalez, Alina Lujan; Fernandez Zapico, Martín E.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.
Fil: Vera, Renzo. No especifíca;
Fil: Lamberti, María Julia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Gonzalez, Alina Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Fernandez Zapico, Martín E.. No especifíca;
Materia
Epigenetics
Pancreatic cancer
Tumor microenvironment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/259381
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancerVera, RenzoLamberti, María JuliaGonzalez, Alina LujanFernandez Zapico, Martín E.EpigeneticsPancreatic cancerTumor microenvironmenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.Fil: Vera, Renzo. No especifíca;Fil: Lamberti, María Julia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; ArgentinaFil: Gonzalez, Alina Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Fernandez Zapico, Martín E.. No especifíca;Elsevier2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/259381Vera, Renzo; Lamberti, María Julia; Gonzalez, Alina Lujan; Fernandez Zapico, Martín E.; Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer; Elsevier; Pancreatology; 24; 6; 7-2024; 878-8861424-3903CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1424390324006859info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pan.2024.07.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:47:54Zoai:ri.conicet.gov.ar:11336/259381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:47:54.529CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
title Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
spellingShingle Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
Vera, Renzo
Epigenetics
Pancreatic cancer
Tumor microenvironment
title_short Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
title_full Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
title_fullStr Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
title_full_unstemmed Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
title_sort Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer
dc.creator.none.fl_str_mv Vera, Renzo
Lamberti, María Julia
Gonzalez, Alina Lujan
Fernandez Zapico, Martín E.
author Vera, Renzo
author_facet Vera, Renzo
Lamberti, María Julia
Gonzalez, Alina Lujan
Fernandez Zapico, Martín E.
author_role author
author2 Lamberti, María Julia
Gonzalez, Alina Lujan
Fernandez Zapico, Martín E.
author2_role author
author
author
dc.subject.none.fl_str_mv Epigenetics
Pancreatic cancer
Tumor microenvironment
topic Epigenetics
Pancreatic cancer
Tumor microenvironment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.
Fil: Vera, Renzo. No especifíca;
Fil: Lamberti, María Julia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Gonzalez, Alina Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Fernandez Zapico, Martín E.. No especifíca;
description Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/259381
Vera, Renzo; Lamberti, María Julia; Gonzalez, Alina Lujan; Fernandez Zapico, Martín E.; Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer; Elsevier; Pancreatology; 24; 6; 7-2024; 878-886
1424-3903
CONICET Digital
CONICET
url http://hdl.handle.net/11336/259381
identifier_str_mv Vera, Renzo; Lamberti, María Julia; Gonzalez, Alina Lujan; Fernandez Zapico, Martín E.; Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer; Elsevier; Pancreatology; 24; 6; 7-2024; 878-886
1424-3903
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1424390324006859
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pan.2024.07.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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