Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
- Autores
- Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy.
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Fil: Borroni, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina - Materia
-
ACETYLCHOLINE RECEPTOR
ALZHEIMER'S DISEASE
CHOLESTEROL
NICOTINIC
RECEPTOR
SYNAPSE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/41482
Ver los metadatos del registro completo
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Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's diseaseBarrantes, Francisco JoseBorroni, Maria VirginiaValles, Ana SofiaACETYLCHOLINE RECEPTORALZHEIMER'S DISEASECHOLESTEROLNICOTINICRECEPTORSYNAPSEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy.Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; ArgentinaFil: Borroni, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; ArgentinaFil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; ArgentinaElsevier Science2010-05-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41482Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia; Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease; Elsevier Science; FEBS Letters; 584; 9; 3-5-2010; 1856-18630014-5793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014579309009405info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2009.11.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:09Zoai:ri.conicet.gov.ar:11336/41482instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:09.762CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
title |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
spellingShingle |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease Barrantes, Francisco Jose ACETYLCHOLINE RECEPTOR ALZHEIMER'S DISEASE CHOLESTEROL NICOTINIC RECEPTOR SYNAPSE |
title_short |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
title_full |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
title_fullStr |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
title_full_unstemmed |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
title_sort |
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease |
dc.creator.none.fl_str_mv |
Barrantes, Francisco Jose Borroni, Maria Virginia Valles, Ana Sofia |
author |
Barrantes, Francisco Jose |
author_facet |
Barrantes, Francisco Jose Borroni, Maria Virginia Valles, Ana Sofia |
author_role |
author |
author2 |
Borroni, Maria Virginia Valles, Ana Sofia |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ACETYLCHOLINE RECEPTOR ALZHEIMER'S DISEASE CHOLESTEROL NICOTINIC RECEPTOR SYNAPSE |
topic |
ACETYLCHOLINE RECEPTOR ALZHEIMER'S DISEASE CHOLESTEROL NICOTINIC RECEPTOR SYNAPSE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy. Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina Fil: Borroni, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina |
description |
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-05-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/41482 Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia; Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease; Elsevier Science; FEBS Letters; 584; 9; 3-5-2010; 1856-1863 0014-5793 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/41482 |
identifier_str_mv |
Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia; Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease; Elsevier Science; FEBS Letters; 584; 9; 3-5-2010; 1856-1863 0014-5793 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014579309009405 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2009.11.036 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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score |
13.13397 |