Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease

Autores
Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy.
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Fil: Borroni, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Materia
ACETYLCHOLINE RECEPTOR
ALZHEIMER'S DISEASE
CHOLESTEROL
NICOTINIC
RECEPTOR
SYNAPSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41482
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's diseaseBarrantes, Francisco JoseBorroni, Maria VirginiaValles, Ana SofiaACETYLCHOLINE RECEPTORALZHEIMER'S DISEASECHOLESTEROLNICOTINICRECEPTORSYNAPSEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy.Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; ArgentinaFil: Borroni, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; ArgentinaFil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; ArgentinaElsevier Science2010-05-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41482Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia; Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease; Elsevier Science; FEBS Letters; 584; 9; 3-5-2010; 1856-18630014-5793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014579309009405info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2009.11.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:28Zoai:ri.conicet.gov.ar:11336/41482instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:28.386CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
title Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
spellingShingle Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
Barrantes, Francisco Jose
ACETYLCHOLINE RECEPTOR
ALZHEIMER'S DISEASE
CHOLESTEROL
NICOTINIC
RECEPTOR
SYNAPSE
title_short Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
title_full Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
title_fullStr Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
title_full_unstemmed Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
title_sort Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
dc.creator.none.fl_str_mv Barrantes, Francisco Jose
Borroni, Maria Virginia
Valles, Ana Sofia
author Barrantes, Francisco Jose
author_facet Barrantes, Francisco Jose
Borroni, Maria Virginia
Valles, Ana Sofia
author_role author
author2 Borroni, Maria Virginia
Valles, Ana Sofia
author2_role author
author
dc.subject.none.fl_str_mv ACETYLCHOLINE RECEPTOR
ALZHEIMER'S DISEASE
CHOLESTEROL
NICOTINIC
RECEPTOR
SYNAPSE
topic ACETYLCHOLINE RECEPTOR
ALZHEIMER'S DISEASE
CHOLESTEROL
NICOTINIC
RECEPTOR
SYNAPSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy.
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Fil: Borroni, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Unesco; Argentina
description Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy.
publishDate 2010
dc.date.none.fl_str_mv 2010-05-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41482
Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia; Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease; Elsevier Science; FEBS Letters; 584; 9; 3-5-2010; 1856-1863
0014-5793
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41482
identifier_str_mv Barrantes, Francisco Jose; Borroni, Maria Virginia; Valles, Ana Sofia; Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease; Elsevier Science; FEBS Letters; 584; 9; 3-5-2010; 1856-1863
0014-5793
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014579309009405
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2009.11.036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613891590455296
score 13.070432

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