Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats

Autores
Brance, María Lorena; Brun, Lucas Ricardo Martín; Di Loreto, Verónica Elina; Lupo, Maela; Rigalli, Alfredo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective Osteoporosis is the consequence of an imbalance in bone remodeling caused by excessive resorption or inappropriate bone formation. This paper proposes a sequential treatment with monofl uorophosphate (MFP) and zoledronic acid (Z), together with changes in the calcium content in the diet. Method Seven-week-old female Sprague Dawley rats were divided into fi ve groups ( n 21 per group): (1) sham-operated rats (Sham); (2) ovariectomized (OVX) rats fed with a normal calcium diet (OVX); (3) OVX rats fed with a normal calcium diet and treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G1); (4) OVX rats sequentially fed with a low calcium diet and then a high calcium diet, without treatment (OVX.G2); (5): OVX rats fed with a low calcium diet and then a high calcium diet, treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G3). Results After 150 days, the OVX.G3 group showed a similar bone volume to that of the Sham group due to an increase in trabecular number. Dual X-ray absorptiometry bone analysis showed an increase of 9.8% compared with OVX rats. Additionally, an increase in the fracture load at the cortical bone and higher fracture load, ultimate load and stiffness in the compression test were found. Conclusion The sequential treatment with monofl uorophosphate and zoledronic acid increases trabecular bone mass, bone mineral density and bone strength.
Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Lupo, Maela. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Consejo de Investigación; Argentina
Materia
Monofluorophosphate
Zoledronic Acid
Osteoporosis
Bone Mass
Bone Strength
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30250
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/30250
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic ratsBrance, María LorenaBrun, Lucas Ricardo MartínDi Loreto, Verónica ElinaLupo, MaelaRigalli, AlfredoMonofluorophosphateZoledronic AcidOsteoporosisBone MassBone Strengthhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objective Osteoporosis is the consequence of an imbalance in bone remodeling caused by excessive resorption or inappropriate bone formation. This paper proposes a sequential treatment with monofl uorophosphate (MFP) and zoledronic acid (Z), together with changes in the calcium content in the diet. Method Seven-week-old female Sprague Dawley rats were divided into fi ve groups ( n 21 per group): (1) sham-operated rats (Sham); (2) ovariectomized (OVX) rats fed with a normal calcium diet (OVX); (3) OVX rats fed with a normal calcium diet and treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G1); (4) OVX rats sequentially fed with a low calcium diet and then a high calcium diet, without treatment (OVX.G2); (5): OVX rats fed with a low calcium diet and then a high calcium diet, treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G3). Results After 150 days, the OVX.G3 group showed a similar bone volume to that of the Sham group due to an increase in trabecular number. Dual X-ray absorptiometry bone analysis showed an increase of 9.8% compared with OVX rats. Additionally, an increase in the fracture load at the cortical bone and higher fracture load, ultimate load and stiffness in the compression test were found. Conclusion The sequential treatment with monofl uorophosphate and zoledronic acid increases trabecular bone mass, bone mineral density and bone strength.Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Lupo, Maela. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Consejo de Investigación; ArgentinaTaylor & Francis Ltd2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30250Brance, María Lorena; Brun, Lucas Ricardo Martín; Di Loreto, Verónica Elina; Lupo, Maela; Rigalli, Alfredo; Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats; Taylor & Francis Ltd; Climacteric; 17; 4; 8-2014; 478-4851369-71371473-0804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/13697137.2013.860117info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/13697137.2013.860117info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:29:46Zoai:ri.conicet.gov.ar:11336/30250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:29:47.016CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
title Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
spellingShingle Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
Brance, María Lorena
Monofluorophosphate
Zoledronic Acid
Osteoporosis
Bone Mass
Bone Strength
title_short Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
title_full Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
title_fullStr Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
title_full_unstemmed Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
title_sort Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
dc.creator.none.fl_str_mv Brance, María Lorena
Brun, Lucas Ricardo Martín
Di Loreto, Verónica Elina
Lupo, Maela
Rigalli, Alfredo
author Brance, María Lorena
author_facet Brance, María Lorena
Brun, Lucas Ricardo Martín
Di Loreto, Verónica Elina
Lupo, Maela
Rigalli, Alfredo
author_role author
author2 Brun, Lucas Ricardo Martín
Di Loreto, Verónica Elina
Lupo, Maela
Rigalli, Alfredo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Monofluorophosphate
Zoledronic Acid
Osteoporosis
Bone Mass
Bone Strength
topic Monofluorophosphate
Zoledronic Acid
Osteoporosis
Bone Mass
Bone Strength
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective Osteoporosis is the consequence of an imbalance in bone remodeling caused by excessive resorption or inappropriate bone formation. This paper proposes a sequential treatment with monofl uorophosphate (MFP) and zoledronic acid (Z), together with changes in the calcium content in the diet. Method Seven-week-old female Sprague Dawley rats were divided into fi ve groups ( n 21 per group): (1) sham-operated rats (Sham); (2) ovariectomized (OVX) rats fed with a normal calcium diet (OVX); (3) OVX rats fed with a normal calcium diet and treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G1); (4) OVX rats sequentially fed with a low calcium diet and then a high calcium diet, without treatment (OVX.G2); (5): OVX rats fed with a low calcium diet and then a high calcium diet, treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G3). Results After 150 days, the OVX.G3 group showed a similar bone volume to that of the Sham group due to an increase in trabecular number. Dual X-ray absorptiometry bone analysis showed an increase of 9.8% compared with OVX rats. Additionally, an increase in the fracture load at the cortical bone and higher fracture load, ultimate load and stiffness in the compression test were found. Conclusion The sequential treatment with monofl uorophosphate and zoledronic acid increases trabecular bone mass, bone mineral density and bone strength.
Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Lupo, Maela. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Consejo de Investigación; Argentina
description Objective Osteoporosis is the consequence of an imbalance in bone remodeling caused by excessive resorption or inappropriate bone formation. This paper proposes a sequential treatment with monofl uorophosphate (MFP) and zoledronic acid (Z), together with changes in the calcium content in the diet. Method Seven-week-old female Sprague Dawley rats were divided into fi ve groups ( n 21 per group): (1) sham-operated rats (Sham); (2) ovariectomized (OVX) rats fed with a normal calcium diet (OVX); (3) OVX rats fed with a normal calcium diet and treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G1); (4) OVX rats sequentially fed with a low calcium diet and then a high calcium diet, without treatment (OVX.G2); (5): OVX rats fed with a low calcium diet and then a high calcium diet, treated sequentially with monofl uorophosphate and zoledronic acid (OVX.G3). Results After 150 days, the OVX.G3 group showed a similar bone volume to that of the Sham group due to an increase in trabecular number. Dual X-ray absorptiometry bone analysis showed an increase of 9.8% compared with OVX rats. Additionally, an increase in the fracture load at the cortical bone and higher fracture load, ultimate load and stiffness in the compression test were found. Conclusion The sequential treatment with monofl uorophosphate and zoledronic acid increases trabecular bone mass, bone mineral density and bone strength.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30250
Brance, María Lorena; Brun, Lucas Ricardo Martín; Di Loreto, Verónica Elina; Lupo, Maela; Rigalli, Alfredo; Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats; Taylor & Francis Ltd; Climacteric; 17; 4; 8-2014; 478-485
1369-7137
1473-0804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30250
identifier_str_mv Brance, María Lorena; Brun, Lucas Ricardo Martín; Di Loreto, Verónica Elina; Lupo, Maela; Rigalli, Alfredo; Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats; Taylor & Francis Ltd; Climacteric; 17; 4; 8-2014; 478-485
1369-7137
1473-0804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/13697137.2013.860117
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/13697137.2013.860117
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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