The role of renin in experimental hypertension
- Autores
- Houssay, Bernardo Alberto; Braun Menéndez, Eduardo
- Año de publicación
- 1942
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938
Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Braun Menéndez, Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina
fondo - Materia
-
HISTORIA DE LA CIENCIA
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTÍFICAS
PUBLICACIONES
EL INVESTIGADOR
RENINA
HIPERTENSIÓN EXPERIMENTAL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/123526
Ver los metadatos del registro completo
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The role of renin in experimental hypertensionHoussay, Bernardo AlbertoBraun Menéndez, EduardoHISTORIA DE LA CIENCIAHOUSSAY, BERNARDO ALBERTOHOUSSAY EL INVESTIGADORPUBLICACIONES CIENTÍFICASPUBLICACIONESEL INVESTIGADORRENINAHIPERTENSIÓN EXPERIMENTALhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Braun Menéndez, Eduardo. Universidad de Buenos Aires. Facultad de Medicina; ArgentinafondoThe British Medical Association1942-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/pdfhttp://hdl.handle.net/11336/123526Houssay, Bernardo Alberto; Braun Menéndez, Eduardo; The role of renin in experimental hypertension; The British Medical Association; British Medical Journal; 2; 4258; 15-8-1942; 179-1811759-2151enginfo:eu-repo/semantics/altIdentifier/doi/10.1136/bmj.2.4258.179Ciudad de Buenos AiresFundacion Williams.Fundación de Instituto de Biología y Medicina ExperimentalConsejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y Leloirinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:54Zoai:ri.conicet.gov.ar:11336/123526instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:54.547CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The role of renin in experimental hypertension |
title |
The role of renin in experimental hypertension |
spellingShingle |
The role of renin in experimental hypertension Houssay, Bernardo Alberto HISTORIA DE LA CIENCIA HOUSSAY, BERNARDO ALBERTO HOUSSAY EL INVESTIGADOR PUBLICACIONES CIENTÍFICAS PUBLICACIONES EL INVESTIGADOR RENINA HIPERTENSIÓN EXPERIMENTAL |
title_short |
The role of renin in experimental hypertension |
title_full |
The role of renin in experimental hypertension |
title_fullStr |
The role of renin in experimental hypertension |
title_full_unstemmed |
The role of renin in experimental hypertension |
title_sort |
The role of renin in experimental hypertension |
dc.creator.none.fl_str_mv |
Houssay, Bernardo Alberto Braun Menéndez, Eduardo |
author |
Houssay, Bernardo Alberto |
author_facet |
Houssay, Bernardo Alberto Braun Menéndez, Eduardo |
author_role |
author |
author2 |
Braun Menéndez, Eduardo |
author2_role |
author |
dc.subject.none.fl_str_mv |
HISTORIA DE LA CIENCIA HOUSSAY, BERNARDO ALBERTO HOUSSAY EL INVESTIGADOR PUBLICACIONES CIENTÍFICAS PUBLICACIONES EL INVESTIGADOR RENINA HIPERTENSIÓN EXPERIMENTAL |
topic |
HISTORIA DE LA CIENCIA HOUSSAY, BERNARDO ALBERTO HOUSSAY EL INVESTIGADOR PUBLICACIONES CIENTÍFICAS PUBLICACIONES EL INVESTIGADOR RENINA HIPERTENSIÓN EXPERIMENTAL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938 Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Braun Menéndez, Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina fondo |
description |
In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938 |
publishDate |
1942 |
dc.date.none.fl_str_mv |
1942-08-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/123526 Houssay, Bernardo Alberto; Braun Menéndez, Eduardo; The role of renin in experimental hypertension; The British Medical Association; British Medical Journal; 2; 4258; 15-8-1942; 179-181 1759-2151 |
url |
http://hdl.handle.net/11336/123526 |
identifier_str_mv |
Houssay, Bernardo Alberto; Braun Menéndez, Eduardo; The role of renin in experimental hypertension; The British Medical Association; British Medical Journal; 2; 4258; 15-8-1942; 179-181 1759-2151 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1136/bmj.2.4258.179 Ciudad de Buenos Aires Fundacion Williams. Fundación de Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas Proyecto Houssay y Leloir |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
text/plain BlancoNegro Si application/pdf |
dc.publisher.none.fl_str_mv |
The British Medical Association |
publisher.none.fl_str_mv |
The British Medical Association |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614306829697024 |
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13.070432 |