The role of renin in experimental hypertension

Autores
Houssay, Bernardo Alberto; Braun Menéndez, Eduardo
Año de publicación
1942
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938
Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Braun Menéndez, Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina
fondo
Materia
HISTORIA DE LA CIENCIA
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTÍFICAS
PUBLICACIONES
EL INVESTIGADOR
RENINA
HIPERTENSIÓN EXPERIMENTAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123526
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123526
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of renin in experimental hypertensionHoussay, Bernardo AlbertoBraun Menéndez, EduardoHISTORIA DE LA CIENCIAHOUSSAY, BERNARDO ALBERTOHOUSSAY EL INVESTIGADORPUBLICACIONES CIENTÍFICASPUBLICACIONESEL INVESTIGADORRENINAHIPERTENSIÓN EXPERIMENTALhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Braun Menéndez, Eduardo. Universidad de Buenos Aires. Facultad de Medicina; ArgentinafondoThe British Medical Association1942-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/pdfhttp://hdl.handle.net/11336/123526Houssay, Bernardo Alberto; Braun Menéndez, Eduardo; The role of renin in experimental hypertension; The British Medical Association; British Medical Journal; 2; 4258; 15-8-1942; 179-1811759-2151enginfo:eu-repo/semantics/altIdentifier/doi/10.1136/bmj.2.4258.179Ciudad de Buenos AiresFundacion Williams.Fundación de Instituto de Biología y Medicina ExperimentalConsejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y Leloirinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:25Zoai:ri.conicet.gov.ar:11336/123526instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:25.995CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of renin in experimental hypertension
title The role of renin in experimental hypertension
spellingShingle The role of renin in experimental hypertension
Houssay, Bernardo Alberto
HISTORIA DE LA CIENCIA
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTÍFICAS
PUBLICACIONES
EL INVESTIGADOR
RENINA
HIPERTENSIÓN EXPERIMENTAL
title_short The role of renin in experimental hypertension
title_full The role of renin in experimental hypertension
title_fullStr The role of renin in experimental hypertension
title_full_unstemmed The role of renin in experimental hypertension
title_sort The role of renin in experimental hypertension
dc.creator.none.fl_str_mv Houssay, Bernardo Alberto
Braun Menéndez, Eduardo
author Houssay, Bernardo Alberto
author_facet Houssay, Bernardo Alberto
Braun Menéndez, Eduardo
author_role author
author2 Braun Menéndez, Eduardo
author2_role author
dc.subject.none.fl_str_mv HISTORIA DE LA CIENCIA
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTÍFICAS
PUBLICACIONES
EL INVESTIGADOR
RENINA
HIPERTENSIÓN EXPERIMENTAL
topic HISTORIA DE LA CIENCIA
HOUSSAY, BERNARDO ALBERTO
HOUSSAY EL INVESTIGADOR
PUBLICACIONES CIENTÍFICAS
PUBLICACIONES
EL INVESTIGADOR
RENINA
HIPERTENSIÓN EXPERIMENTAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938
Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Braun Menéndez, Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina
fondo
description In 1934 Goldblatt and others discovered that partial constriction of the main renal artery produces a marked and permanent hypertension in the dog. The renal experimental hypertension caused by this or other methods in laboratory animals is similar in many respects to human essential hypertension. It is not due to excretory insufficiency of the kidney or to an increase of blood volume or cardiac output, nor is it produced through a nervous mechanism. Houssay and Fasciolo (1937a, 1937b) have shown that renal ischaemia results in hypertension through a humoral mechanism. The ischaemic kidneys of dogs with chronic hypertension were grafted into the neck of normal or nephrectomized dogs. The arterial pressure of the recipient dog rose from 30 to 80 mm. Hg in 5 to 10 minutes, while grafting a normal kidney had no such effect. The citrated plasma obtained from the veins of these ischaemic kidneys produced vasoconstriction when perfused through a Lawen-Trendelenburg preparation; normal plasma had no vasoconstrictor action (Houssay and Taquini, 1938
publishDate 1942
dc.date.none.fl_str_mv 1942-08-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123526
Houssay, Bernardo Alberto; Braun Menéndez, Eduardo; The role of renin in experimental hypertension; The British Medical Association; British Medical Journal; 2; 4258; 15-8-1942; 179-181
1759-2151
url http://hdl.handle.net/11336/123526
identifier_str_mv Houssay, Bernardo Alberto; Braun Menéndez, Eduardo; The role of renin in experimental hypertension; The British Medical Association; British Medical Journal; 2; 4258; 15-8-1942; 179-181
1759-2151
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1136/bmj.2.4258.179
Ciudad de Buenos Aires
Fundacion Williams.
Fundación de Instituto de Biología y Medicina Experimental
Consejo Nacional de Investigaciones Científicas y Técnicas
Proyecto Houssay y Leloir
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv text/plain
BlancoNegro
Si
application/pdf
dc.publisher.none.fl_str_mv The British Medical Association
publisher.none.fl_str_mv The British Medical Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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