Chemistry and Biological Activity of Coumarins at Molecular Level

Autores
Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: García, Celina. Universidad de la Laguna; España
Fil: Martin, Víctor S.. Universidad de la Laguna; España
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Materia
Coumarins
Molecular Target
Antitumoral
Antiretroviral
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5886
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Chemistry and Biological Activity of Coumarins at Molecular LevelGarro, Hugo AlejandroGarcía, CelinaMartin, Víctor S.Pungitore, Carlos RodolfoTonn, Carlos EugenioCoumarinsMolecular TargetAntitumoralAntiretroviralhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: García, Celina. Universidad de la Laguna; EspañaFil: Martin, Víctor S.. Universidad de la Laguna; EspañaFil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; ArgentinaNatural Products2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5886Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-10941934-578Xenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:49:40Zoai:ri.conicet.gov.ar:11336/5886instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:49:41.221CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chemistry and Biological Activity of Coumarins at Molecular Level
title Chemistry and Biological Activity of Coumarins at Molecular Level
spellingShingle Chemistry and Biological Activity of Coumarins at Molecular Level
Garro, Hugo Alejandro
Coumarins
Molecular Target
Antitumoral
Antiretroviral
title_short Chemistry and Biological Activity of Coumarins at Molecular Level
title_full Chemistry and Biological Activity of Coumarins at Molecular Level
title_fullStr Chemistry and Biological Activity of Coumarins at Molecular Level
title_full_unstemmed Chemistry and Biological Activity of Coumarins at Molecular Level
title_sort Chemistry and Biological Activity of Coumarins at Molecular Level
dc.creator.none.fl_str_mv Garro, Hugo Alejandro
García, Celina
Martin, Víctor S.
Pungitore, Carlos Rodolfo
Tonn, Carlos Eugenio
author Garro, Hugo Alejandro
author_facet Garro, Hugo Alejandro
García, Celina
Martin, Víctor S.
Pungitore, Carlos Rodolfo
Tonn, Carlos Eugenio
author_role author
author2 García, Celina
Martin, Víctor S.
Pungitore, Carlos Rodolfo
Tonn, Carlos Eugenio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Coumarins
Molecular Target
Antitumoral
Antiretroviral
topic Coumarins
Molecular Target
Antitumoral
Antiretroviral
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: García, Celina. Universidad de la Laguna; España
Fil: Martin, Víctor S.. Universidad de la Laguna; España
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
description Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5886
Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094
1934-578X
url http://hdl.handle.net/11336/5886
identifier_str_mv Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094
1934-578X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900808
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Natural Products
publisher.none.fl_str_mv Natural Products
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848598083530653696
score 13.24909

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