Chemistry and Biological Activity of Coumarins at Molecular Level
- Autores
- Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: García, Celina. Universidad de la Laguna; España
Fil: Martin, Víctor S.. Universidad de la Laguna; España
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina - Materia
-
Coumarins
Molecular Target
Antitumoral
Antiretroviral - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/5886
Ver los metadatos del registro completo
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Chemistry and Biological Activity of Coumarins at Molecular LevelGarro, Hugo AlejandroGarcía, CelinaMartin, Víctor S.Pungitore, Carlos RodolfoTonn, Carlos EugenioCoumarinsMolecular TargetAntitumoralAntiretroviralhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: García, Celina. Universidad de la Laguna; EspañaFil: Martin, Víctor S.. Universidad de la Laguna; EspañaFil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; ArgentinaNatural Products2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5886Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-10941934-578Xenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:56Zoai:ri.conicet.gov.ar:11336/5886instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:56.816CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Chemistry and Biological Activity of Coumarins at Molecular Level |
title |
Chemistry and Biological Activity of Coumarins at Molecular Level |
spellingShingle |
Chemistry and Biological Activity of Coumarins at Molecular Level Garro, Hugo Alejandro Coumarins Molecular Target Antitumoral Antiretroviral |
title_short |
Chemistry and Biological Activity of Coumarins at Molecular Level |
title_full |
Chemistry and Biological Activity of Coumarins at Molecular Level |
title_fullStr |
Chemistry and Biological Activity of Coumarins at Molecular Level |
title_full_unstemmed |
Chemistry and Biological Activity of Coumarins at Molecular Level |
title_sort |
Chemistry and Biological Activity of Coumarins at Molecular Level |
dc.creator.none.fl_str_mv |
Garro, Hugo Alejandro García, Celina Martin, Víctor S. Pungitore, Carlos Rodolfo Tonn, Carlos Eugenio |
author |
Garro, Hugo Alejandro |
author_facet |
Garro, Hugo Alejandro García, Celina Martin, Víctor S. Pungitore, Carlos Rodolfo Tonn, Carlos Eugenio |
author_role |
author |
author2 |
García, Celina Martin, Víctor S. Pungitore, Carlos Rodolfo Tonn, Carlos Eugenio |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Coumarins Molecular Target Antitumoral Antiretroviral |
topic |
Coumarins Molecular Target Antitumoral Antiretroviral |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs. Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina Fil: García, Celina. Universidad de la Laguna; España Fil: Martin, Víctor S.. Universidad de la Laguna; España Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina |
description |
Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/5886 Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094 1934-578X |
url |
http://hdl.handle.net/11336/5886 |
identifier_str_mv |
Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094 1934-578X |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900808 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Natural Products |
publisher.none.fl_str_mv |
Natural Products |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |