ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory

Autores
Medina, Jorge Horacio; Viola, Haydee Ana Maria
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Viola, Haydee Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Materia
DURABILITY
ERK1/2
EXTINCTION
LONG-TERM MEMORY
RECONSOLIDATION
RETRIEVAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88095
Acceder
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network_name_str CONICET Digital (CONICET)
spelling ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of MemoryMedina, Jorge HoracioViola, Haydee Ana MariaDURABILITYERK1/2EXTINCTIONLONG-TERM MEMORYRECONSOLIDATIONRETRIEVALhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Viola, Haydee Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFrontiers Media S.A.2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88095Medina, Jorge Horacio; Viola, Haydee Ana Maria; ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory; Frontiers Media S.A.; Frontiers in Molecular Neuroscience; 11; 361; 10-2018; 1-81662-5099CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnmol.2018.00361info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnmol.2018.00361/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:15Zoai:ri.conicet.gov.ar:11336/88095instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:15.446CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
spellingShingle ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
Medina, Jorge Horacio
DURABILITY
ERK1/2
EXTINCTION
LONG-TERM MEMORY
RECONSOLIDATION
RETRIEVAL
title_short ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_full ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_fullStr ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_full_unstemmed ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_sort ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
dc.creator.none.fl_str_mv Medina, Jorge Horacio
Viola, Haydee Ana Maria
author Medina, Jorge Horacio
author_facet Medina, Jorge Horacio
Viola, Haydee Ana Maria
author_role author
author2 Viola, Haydee Ana Maria
author2_role author
dc.subject.none.fl_str_mv DURABILITY
ERK1/2
EXTINCTION
LONG-TERM MEMORY
RECONSOLIDATION
RETRIEVAL
topic DURABILITY
ERK1/2
EXTINCTION
LONG-TERM MEMORY
RECONSOLIDATION
RETRIEVAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Viola, Haydee Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
description Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88095
Medina, Jorge Horacio; Viola, Haydee Ana Maria; ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory; Frontiers Media S.A.; Frontiers in Molecular Neuroscience; 11; 361; 10-2018; 1-8
1662-5099
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88095
identifier_str_mv Medina, Jorge Horacio; Viola, Haydee Ana Maria; ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory; Frontiers Media S.A.; Frontiers in Molecular Neuroscience; 11; 361; 10-2018; 1-8
1662-5099
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fnmol.2018.00361
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnmol.2018.00361/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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