The transition from memory retrieval to extinction

Autores
Cammarota, Martin Pablo; Barros, Daniela M.; Vianna, Mónica R.M.; Bevilaqua, Lia R.M.; Coitinho, Adriana; Szapiro, Germán; Izquierdo, Luciana A.; Medina, Jorge Horacio; Izquierdo, Iván
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation Of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace.
Fil: Cammarota, Martin Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Barros, Daniela M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Vianna, Mónica R.M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bevilaqua, Lia R.M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Coitinho, Adriana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Szapiro, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Izquierdo, Luciana A.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Izquierdo, Iván. Universidade Federal do Rio Grande do Sul; Brasil
Materia
EXTINCTION
INHIBITORY AVOIDANCE
MEMORY
RECONSOLIDATION
RETRIEVAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147350
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/147350
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The transition from memory retrieval to extinctionCammarota, Martin PabloBarros, Daniela M.Vianna, Mónica R.M.Bevilaqua, Lia R.M.Coitinho, AdrianaSzapiro, GermánIzquierdo, Luciana A.Medina, Jorge HoracioIzquierdo, IvánEXTINCTIONINHIBITORY AVOIDANCEMEMORYRECONSOLIDATIONRETRIEVALhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation Of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace.Fil: Cammarota, Martin Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Barros, Daniela M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Vianna, Mónica R.M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Bevilaqua, Lia R.M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Coitinho, Adriana. Universidade Federal do Rio Grande do Sul; BrasilFil: Szapiro, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Izquierdo, Luciana A.. Universidade Federal do Rio Grande do Sul; BrasilFil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Izquierdo, Iván. Universidade Federal do Rio Grande do Sul; BrasilAcademia Brasileira de Ciencias2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147350Cammarota, Martin Pablo; Barros, Daniela M.; Vianna, Mónica R.M.; Bevilaqua, Lia R.M.; Coitinho, Adriana; et al.; The transition from memory retrieval to extinction; Academia Brasileira de Ciencias; Anais da Academia Brasileira de Ciencias; 76; 3; 12-2004; 573-5820001-37651678-2690CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1590/s0001-37652004000300011info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/j/aabc/a/tw6kW9RN7gBdXMvQrBS7rYK/?lang=eninfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:23Zoai:ri.conicet.gov.ar:11336/147350instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:25.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The transition from memory retrieval to extinction
title The transition from memory retrieval to extinction
spellingShingle The transition from memory retrieval to extinction
Cammarota, Martin Pablo
EXTINCTION
INHIBITORY AVOIDANCE
MEMORY
RECONSOLIDATION
RETRIEVAL
title_short The transition from memory retrieval to extinction
title_full The transition from memory retrieval to extinction
title_fullStr The transition from memory retrieval to extinction
title_full_unstemmed The transition from memory retrieval to extinction
title_sort The transition from memory retrieval to extinction
dc.creator.none.fl_str_mv Cammarota, Martin Pablo
Barros, Daniela M.
Vianna, Mónica R.M.
Bevilaqua, Lia R.M.
Coitinho, Adriana
Szapiro, Germán
Izquierdo, Luciana A.
Medina, Jorge Horacio
Izquierdo, Iván
author Cammarota, Martin Pablo
author_facet Cammarota, Martin Pablo
Barros, Daniela M.
Vianna, Mónica R.M.
Bevilaqua, Lia R.M.
Coitinho, Adriana
Szapiro, Germán
Izquierdo, Luciana A.
Medina, Jorge Horacio
Izquierdo, Iván
author_role author
author2 Barros, Daniela M.
Vianna, Mónica R.M.
Bevilaqua, Lia R.M.
Coitinho, Adriana
Szapiro, Germán
Izquierdo, Luciana A.
Medina, Jorge Horacio
Izquierdo, Iván
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EXTINCTION
INHIBITORY AVOIDANCE
MEMORY
RECONSOLIDATION
RETRIEVAL
topic EXTINCTION
INHIBITORY AVOIDANCE
MEMORY
RECONSOLIDATION
RETRIEVAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation Of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace.
Fil: Cammarota, Martin Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Barros, Daniela M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Vianna, Mónica R.M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bevilaqua, Lia R.M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Coitinho, Adriana. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Szapiro, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Izquierdo, Luciana A.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Izquierdo, Iván. Universidade Federal do Rio Grande do Sul; Brasil
description Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation Of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147350
Cammarota, Martin Pablo; Barros, Daniela M.; Vianna, Mónica R.M.; Bevilaqua, Lia R.M.; Coitinho, Adriana; et al.; The transition from memory retrieval to extinction; Academia Brasileira de Ciencias; Anais da Academia Brasileira de Ciencias; 76; 3; 12-2004; 573-582
0001-3765
1678-2690
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147350
identifier_str_mv Cammarota, Martin Pablo; Barros, Daniela M.; Vianna, Mónica R.M.; Bevilaqua, Lia R.M.; Coitinho, Adriana; et al.; The transition from memory retrieval to extinction; Academia Brasileira de Ciencias; Anais da Academia Brasileira de Ciencias; 76; 3; 12-2004; 573-582
0001-3765
1678-2690
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/s0001-37652004000300011
info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/j/aabc/a/tw6kW9RN7gBdXMvQrBS7rYK/?lang=en
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciencias
publisher.none.fl_str_mv Academia Brasileira de Ciencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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