New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement

Autores
Castro, Silvina Gabriela; Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Palma, Santiago Daniel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Solid dispersions (SDx) containing Indomethacin (IND), a poorly water-soluble drug,and the disintegrant excipient sodium croscarmellose (SC) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction (XRD) and scanning electron microscopy (SEM). An FT-IR analysis performed on IND-SC solid dispersions and their physical mixtures indicated that IND does not interact with SC in the solid state. An analysis of the information produced by DSC, XRD, and SEM confirmed that the crystalline α-form of IND was homogeneously incorporated into SDx. IND release from SDx was significantly greater than that from its corresponding physical mixtures with the high homogeneous molecular dispersion and the crystalline modification of IND appearing to be the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
Solid dispersions
Sodium croscarmellose
Indomethacin
Co-processed material
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138671
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/138671
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancementCastro, Silvina GabrielaRamírez Rigo, María VeronicaAllemandi, Daniel AlbertoPalma, Santiago DanielSolid dispersionsSodium croscarmelloseIndomethacinCo-processed materialhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Solid dispersions (SDx) containing Indomethacin (IND), a poorly water-soluble drug,and the disintegrant excipient sodium croscarmellose (SC) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction (XRD) and scanning electron microscopy (SEM). An FT-IR analysis performed on IND-SC solid dispersions and their physical mixtures indicated that IND does not interact with SC in the solid state. An analysis of the information produced by DSC, XRD, and SEM confirmed that the crystalline α-form of IND was homogeneously incorporated into SDx. IND release from SDx was significantly greater than that from its corresponding physical mixtures with the high homogeneous molecular dispersion and the crystalline modification of IND appearing to be the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaInternational Pharmaceutical Excipients Council of the Americas2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138671Castro, Silvina Gabriela; Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Palma, Santiago Daniel; New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement; International Pharmaceutical Excipients Council of the Americas; Journal of Excipients and Food Chemicals; 3; 4; 12-2012; 121-1282150-2668CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ojs.abo.fi/ojs/index.php/jefc/article/view/150info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:38Zoai:ri.conicet.gov.ar:11336/138671instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:38.46CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
title New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
spellingShingle New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
Castro, Silvina Gabriela
Solid dispersions
Sodium croscarmellose
Indomethacin
Co-processed material
title_short New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
title_full New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
title_fullStr New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
title_full_unstemmed New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
title_sort New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
dc.creator.none.fl_str_mv Castro, Silvina Gabriela
Ramírez Rigo, María Veronica
Allemandi, Daniel Alberto
Palma, Santiago Daniel
author Castro, Silvina Gabriela
author_facet Castro, Silvina Gabriela
Ramírez Rigo, María Veronica
Allemandi, Daniel Alberto
Palma, Santiago Daniel
author_role author
author2 Ramírez Rigo, María Veronica
Allemandi, Daniel Alberto
Palma, Santiago Daniel
author2_role author
author
author
dc.subject.none.fl_str_mv Solid dispersions
Sodium croscarmellose
Indomethacin
Co-processed material
topic Solid dispersions
Sodium croscarmellose
Indomethacin
Co-processed material
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Solid dispersions (SDx) containing Indomethacin (IND), a poorly water-soluble drug,and the disintegrant excipient sodium croscarmellose (SC) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction (XRD) and scanning electron microscopy (SEM). An FT-IR analysis performed on IND-SC solid dispersions and their physical mixtures indicated that IND does not interact with SC in the solid state. An analysis of the information produced by DSC, XRD, and SEM confirmed that the crystalline α-form of IND was homogeneously incorporated into SDx. IND release from SDx was significantly greater than that from its corresponding physical mixtures with the high homogeneous molecular dispersion and the crystalline modification of IND appearing to be the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Solid dispersions (SDx) containing Indomethacin (IND), a poorly water-soluble drug,and the disintegrant excipient sodium croscarmellose (SC) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction (XRD) and scanning electron microscopy (SEM). An FT-IR analysis performed on IND-SC solid dispersions and their physical mixtures indicated that IND does not interact with SC in the solid state. An analysis of the information produced by DSC, XRD, and SEM confirmed that the crystalline α-form of IND was homogeneously incorporated into SDx. IND release from SDx was significantly greater than that from its corresponding physical mixtures with the high homogeneous molecular dispersion and the crystalline modification of IND appearing to be the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138671
Castro, Silvina Gabriela; Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Palma, Santiago Daniel; New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement; International Pharmaceutical Excipients Council of the Americas; Journal of Excipients and Food Chemicals; 3; 4; 12-2012; 121-128
2150-2668
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138671
identifier_str_mv Castro, Silvina Gabriela; Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Palma, Santiago Daniel; New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement; International Pharmaceutical Excipients Council of the Americas; Journal of Excipients and Food Chemicals; 3; 4; 12-2012; 121-128
2150-2668
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ojs.abo.fi/ojs/index.php/jefc/article/view/150
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Pharmaceutical Excipients Council of the Americas
publisher.none.fl_str_mv International Pharmaceutical Excipients Council of the Americas
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270127900327936
score 13.13397

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