The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species

Autores
Purpora, Rebeca Laura; Massad, Walter Alfredo; Ferrari, Gabriela Verónica; Reynoso, Eugenia; Criado, Susana Noemi; Miskoski, Sandra; Pajares, Adriana Mabel; Garcia, Norman Andino
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diflunisal (DFNS) and Indomethacyn (IMTC) are two profusely employed NSAIDs that provide antiinflammatory and analgesic effects in humans. The scavenging of reactive oxygen species (ROS) by both NSAIDs was systematically studied in pH 7 aqueous solution. The ROS O2(1g), O2?? and H2O2, generated by visible light irradiation of Riboflavin in the presence of DFNS and IMTC, are deactivated by the NSAIDs. It is well known that exacerbated signs of oxidative stress are considered an identifier mark for neurodegenerative disorders. Hence the ROS scavenging action by both NSAIDs constitutes an interesting result in the frame of beneficial actions of these drugs, and adds one more positive aspect to the list of the already attributed properties on the prevention-retardation of neurodegenerative illnesses. DFNS quenches ROS in a dominant physical fashion. It constitutes an excellent scavenger provided that is practically not destroyed/oxidized after the ROS quenching action. On the other hand, IMTC being also an efficient interceptor of ROS, belong to the so-called group of sacrificial-quenchers: It is easily degraded by ROS in the scavenging action. Nevertheless, this property, negative in the context of prolonged ROS elimination, exhibits a promissory aspect for the degradation of pharmaceutical contaminants, such as NSAIDs, in waste waters.
Fil: Purpora, Rebeca Laura. Universidad Nacional de la Patagonia "san Juan Bosco". Facultad de Ingenieria - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Massad, Walter Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrari, Gabriela Verónica. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Reynoso, Eugenia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Criado, Susana Noemi. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miskoski, Sandra. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pajares, Adriana Mabel. Universidad Nacional de la Patagonia "san Juan Bosco". Facultad de Ingenieria - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Diflunisal
Indomethacin
Nsaids
Quenching
Riboflavin
Ros
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7513
Acceder
id CONICETDig_120622426602fac2a4faf4516e8f13f7
oai_identifier_str oai:ri.conicet.gov.ar:11336/7513
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen speciesPurpora, Rebeca LauraMassad, Walter AlfredoFerrari, Gabriela VerónicaReynoso, EugeniaCriado, Susana NoemiMiskoski, SandraPajares, Adriana MabelGarcia, Norman AndinoDiflunisalIndomethacinNsaidsQuenchingRiboflavinRoshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Diflunisal (DFNS) and Indomethacyn (IMTC) are two profusely employed NSAIDs that provide antiinflammatory and analgesic effects in humans. The scavenging of reactive oxygen species (ROS) by both NSAIDs was systematically studied in pH 7 aqueous solution. The ROS O2(1g), O2?? and H2O2, generated by visible light irradiation of Riboflavin in the presence of DFNS and IMTC, are deactivated by the NSAIDs. It is well known that exacerbated signs of oxidative stress are considered an identifier mark for neurodegenerative disorders. Hence the ROS scavenging action by both NSAIDs constitutes an interesting result in the frame of beneficial actions of these drugs, and adds one more positive aspect to the list of the already attributed properties on the prevention-retardation of neurodegenerative illnesses. DFNS quenches ROS in a dominant physical fashion. It constitutes an excellent scavenger provided that is practically not destroyed/oxidized after the ROS quenching action. On the other hand, IMTC being also an efficient interceptor of ROS, belong to the so-called group of sacrificial-quenchers: It is easily degraded by ROS in the scavenging action. Nevertheless, this property, negative in the context of prolonged ROS elimination, exhibits a promissory aspect for the degradation of pharmaceutical contaminants, such as NSAIDs, in waste waters.Fil: Purpora, Rebeca Laura. Universidad Nacional de la Patagonia "san Juan Bosco". Facultad de Ingenieria - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Massad, Walter Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrari, Gabriela Verónica. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Reynoso, Eugenia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Criado, Susana Noemi. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miskoski, Sandra. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pajares, Adriana Mabel. Universidad Nacional de la Patagonia "san Juan Bosco". Facultad de Ingenieria - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/zipapplication/zipapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7513Purpora, Rebeca Laura; Massad, Walter Alfredo; Ferrari, Gabriela Verónica; Reynoso, Eugenia; Criado, Susana Noemi; et al.; The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species; Wiley; Photochemistry and Photobiology; 89; 6; 6-2013; 1463-14700031-8655enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/php.12114/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/php.12114info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:44Zoai:ri.conicet.gov.ar:11336/7513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:45.208CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
title The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
spellingShingle The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
Purpora, Rebeca Laura
Diflunisal
Indomethacin
Nsaids
Quenching
Riboflavin
Ros
title_short The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
title_full The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
title_fullStr The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
title_full_unstemmed The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
title_sort The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species
dc.creator.none.fl_str_mv Purpora, Rebeca Laura
Massad, Walter Alfredo
Ferrari, Gabriela Verónica
Reynoso, Eugenia
Criado, Susana Noemi
Miskoski, Sandra
Pajares, Adriana Mabel
Garcia, Norman Andino
author Purpora, Rebeca Laura
author_facet Purpora, Rebeca Laura
Massad, Walter Alfredo
Ferrari, Gabriela Verónica
Reynoso, Eugenia
Criado, Susana Noemi
Miskoski, Sandra
Pajares, Adriana Mabel
Garcia, Norman Andino
author_role author
author2 Massad, Walter Alfredo
Ferrari, Gabriela Verónica
Reynoso, Eugenia
Criado, Susana Noemi
Miskoski, Sandra
Pajares, Adriana Mabel
Garcia, Norman Andino
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diflunisal
Indomethacin
Nsaids
Quenching
Riboflavin
Ros
topic Diflunisal
Indomethacin
Nsaids
Quenching
Riboflavin
Ros
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Diflunisal (DFNS) and Indomethacyn (IMTC) are two profusely employed NSAIDs that provide antiinflammatory and analgesic effects in humans. The scavenging of reactive oxygen species (ROS) by both NSAIDs was systematically studied in pH 7 aqueous solution. The ROS O2(1g), O2?? and H2O2, generated by visible light irradiation of Riboflavin in the presence of DFNS and IMTC, are deactivated by the NSAIDs. It is well known that exacerbated signs of oxidative stress are considered an identifier mark for neurodegenerative disorders. Hence the ROS scavenging action by both NSAIDs constitutes an interesting result in the frame of beneficial actions of these drugs, and adds one more positive aspect to the list of the already attributed properties on the prevention-retardation of neurodegenerative illnesses. DFNS quenches ROS in a dominant physical fashion. It constitutes an excellent scavenger provided that is practically not destroyed/oxidized after the ROS quenching action. On the other hand, IMTC being also an efficient interceptor of ROS, belong to the so-called group of sacrificial-quenchers: It is easily degraded by ROS in the scavenging action. Nevertheless, this property, negative in the context of prolonged ROS elimination, exhibits a promissory aspect for the degradation of pharmaceutical contaminants, such as NSAIDs, in waste waters.
Fil: Purpora, Rebeca Laura. Universidad Nacional de la Patagonia "san Juan Bosco". Facultad de Ingenieria - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Massad, Walter Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrari, Gabriela Verónica. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Reynoso, Eugenia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Criado, Susana Noemi. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miskoski, Sandra. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pajares, Adriana Mabel. Universidad Nacional de la Patagonia "san Juan Bosco". Facultad de Ingenieria - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Diflunisal (DFNS) and Indomethacyn (IMTC) are two profusely employed NSAIDs that provide antiinflammatory and analgesic effects in humans. The scavenging of reactive oxygen species (ROS) by both NSAIDs was systematically studied in pH 7 aqueous solution. The ROS O2(1g), O2?? and H2O2, generated by visible light irradiation of Riboflavin in the presence of DFNS and IMTC, are deactivated by the NSAIDs. It is well known that exacerbated signs of oxidative stress are considered an identifier mark for neurodegenerative disorders. Hence the ROS scavenging action by both NSAIDs constitutes an interesting result in the frame of beneficial actions of these drugs, and adds one more positive aspect to the list of the already attributed properties on the prevention-retardation of neurodegenerative illnesses. DFNS quenches ROS in a dominant physical fashion. It constitutes an excellent scavenger provided that is practically not destroyed/oxidized after the ROS quenching action. On the other hand, IMTC being also an efficient interceptor of ROS, belong to the so-called group of sacrificial-quenchers: It is easily degraded by ROS in the scavenging action. Nevertheless, this property, negative in the context of prolonged ROS elimination, exhibits a promissory aspect for the degradation of pharmaceutical contaminants, such as NSAIDs, in waste waters.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7513
Purpora, Rebeca Laura; Massad, Walter Alfredo; Ferrari, Gabriela Verónica; Reynoso, Eugenia; Criado, Susana Noemi; et al.; The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species; Wiley; Photochemistry and Photobiology; 89; 6; 6-2013; 1463-1470
0031-8655
url http://hdl.handle.net/11336/7513
identifier_str_mv Purpora, Rebeca Laura; Massad, Walter Alfredo; Ferrari, Gabriela Verónica; Reynoso, Eugenia; Criado, Susana Noemi; et al.; The NSAIDs Indomethacin and Diflunisal as scavengers of photogenerated reactive oxygen species; Wiley; Photochemistry and Photobiology; 89; 6; 6-2013; 1463-1470
0031-8655
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/php.12114/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/php.12114
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/zip
application/zip
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269972720517120
score 13.13397

Publicaciones similares