Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia

Autores
Fridman, Osvaldo; Gariglio Zappellini, Luis Osvaldo; Riviere, Stephanie; Porcile, Rafael; Fuchs, Alicia Graciela; Potenzoni, Miguel
Año de publicación
2016
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. Methods: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR. Paraoxonase and arylesterase activities were determined spectrophotometrically. Blood glucose, cholesterol, triglycerides, HDL, and LDL were measured. Results: PON1 QR192 polymorphism had a major effect on paraoxonase but no effect on arylesterase serum activities. Paraoxonase activity was higher in RR genotype and lowest in QQ genotype. Paraoxonase and arylesterase activities were higher in LL and lower in MM genotypes of PON1 LM55 polymorphism. RQ and LM variants showed intermediate activities between respective homozygous. Elevated concentrations of triglycerides in cases correlate with QQ variant or the presence of M allele. Glucose levels were elevated in cases with QQ variant or with the presence of M allele. Cholesterol and LDL did not show variations in control and cases with any variant of both polymorphisms. HDL is lower in cases with respect to controls independently of genotypes. All differences were significant with p < 0.05.
Fil: Fridman, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
Fil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; Argentina
Fil: Riviere, Stephanie. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
Fil: Porcile, Rafael. Universidad Abierta Interamericana; Argentina
Fil: Fuchs, Alicia Graciela. Universidad Abierta Interamericana; Argentina
Fil: Potenzoni, Miguel. Universidad Abierta Interamericana; Argentina
Materia
Argentina
Coronary Artery Disease
Enzymatic Activities
Genetic Polymorphisms
Glycemia
Lipid Profile
Paraoxonase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38651
Acceder
id CONICETDig_95a57e8c4013cf014f17c6410c3302ea
oai_identifier_str oai:ri.conicet.gov.ar:11336/38651
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemiaPolimorfismos en el gen de la paraoxonasa 1 y sus actividades enzimáticas en la enfermedad coronaria. Su relación con el perfil lipídico y la glucemiaFridman, OsvaldoGariglio Zappellini, Luis OsvaldoRiviere, StephaniePorcile, RafaelFuchs, Alicia GracielaPotenzoni, MiguelArgentinaCoronary Artery DiseaseEnzymatic ActivitiesGenetic PolymorphismsGlycemiaLipid ProfileParaoxonasehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objectives: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. Methods: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR. Paraoxonase and arylesterase activities were determined spectrophotometrically. Blood glucose, cholesterol, triglycerides, HDL, and LDL were measured. Results: PON1 QR192 polymorphism had a major effect on paraoxonase but no effect on arylesterase serum activities. Paraoxonase activity was higher in RR genotype and lowest in QQ genotype. Paraoxonase and arylesterase activities were higher in LL and lower in MM genotypes of PON1 LM55 polymorphism. RQ and LM variants showed intermediate activities between respective homozygous. Elevated concentrations of triglycerides in cases correlate with QQ variant or the presence of M allele. Glucose levels were elevated in cases with QQ variant or with the presence of M allele. Cholesterol and LDL did not show variations in control and cases with any variant of both polymorphisms. HDL is lower in cases with respect to controls independently of genotypes. All differences were significant with p < 0.05.Fil: Fridman, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; ArgentinaFil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; ArgentinaFil: Riviere, Stephanie. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; ArgentinaFil: Porcile, Rafael. Universidad Abierta Interamericana; ArgentinaFil: Fuchs, Alicia Graciela. Universidad Abierta Interamericana; ArgentinaFil: Potenzoni, Miguel. Universidad Abierta Interamericana; ArgentinaElsevier2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38651Fridman, Osvaldo; Gariglio Zappellini, Luis Osvaldo; Riviere, Stephanie; Porcile, Rafael; Fuchs, Alicia Graciela; et al.; Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia; Elsevier; Archivos de Cardiología de México; 86; 4; 10-2016; 350-3571405-9940CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.acmx.2016.08.001info:eu-repo/semantics/altIdentifier/url/http://www.elsevier.es/es-revista-archivos-cardiologia-mexico-293-linkresolver-paraoxonase-1-gene-polymorphisms-enzyme-S1405994016300751info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:06:20Zoai:ri.conicet.gov.ar:11336/38651instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:06:20.833CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
Polimorfismos en el gen de la paraoxonasa 1 y sus actividades enzimáticas en la enfermedad coronaria. Su relación con el perfil lipídico y la glucemia
title Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
spellingShingle Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
Fridman, Osvaldo
Argentina
Coronary Artery Disease
Enzymatic Activities
Genetic Polymorphisms
Glycemia
Lipid Profile
Paraoxonase
title_short Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
title_full Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
title_fullStr Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
title_full_unstemmed Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
title_sort Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
dc.creator.none.fl_str_mv Fridman, Osvaldo
Gariglio Zappellini, Luis Osvaldo
Riviere, Stephanie
Porcile, Rafael
Fuchs, Alicia Graciela
Potenzoni, Miguel
author Fridman, Osvaldo
author_facet Fridman, Osvaldo
Gariglio Zappellini, Luis Osvaldo
Riviere, Stephanie
Porcile, Rafael
Fuchs, Alicia Graciela
Potenzoni, Miguel
author_role author
author2 Gariglio Zappellini, Luis Osvaldo
Riviere, Stephanie
Porcile, Rafael
Fuchs, Alicia Graciela
Potenzoni, Miguel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Argentina
Coronary Artery Disease
Enzymatic Activities
Genetic Polymorphisms
Glycemia
Lipid Profile
Paraoxonase
topic Argentina
Coronary Artery Disease
Enzymatic Activities
Genetic Polymorphisms
Glycemia
Lipid Profile
Paraoxonase
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. Methods: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR. Paraoxonase and arylesterase activities were determined spectrophotometrically. Blood glucose, cholesterol, triglycerides, HDL, and LDL were measured. Results: PON1 QR192 polymorphism had a major effect on paraoxonase but no effect on arylesterase serum activities. Paraoxonase activity was higher in RR genotype and lowest in QQ genotype. Paraoxonase and arylesterase activities were higher in LL and lower in MM genotypes of PON1 LM55 polymorphism. RQ and LM variants showed intermediate activities between respective homozygous. Elevated concentrations of triglycerides in cases correlate with QQ variant or the presence of M allele. Glucose levels were elevated in cases with QQ variant or with the presence of M allele. Cholesterol and LDL did not show variations in control and cases with any variant of both polymorphisms. HDL is lower in cases with respect to controls independently of genotypes. All differences were significant with p < 0.05.
Fil: Fridman, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
Fil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; Argentina
Fil: Riviere, Stephanie. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
Fil: Porcile, Rafael. Universidad Abierta Interamericana; Argentina
Fil: Fuchs, Alicia Graciela. Universidad Abierta Interamericana; Argentina
Fil: Potenzoni, Miguel. Universidad Abierta Interamericana; Argentina
description Objectives: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. Methods: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR. Paraoxonase and arylesterase activities were determined spectrophotometrically. Blood glucose, cholesterol, triglycerides, HDL, and LDL were measured. Results: PON1 QR192 polymorphism had a major effect on paraoxonase but no effect on arylesterase serum activities. Paraoxonase activity was higher in RR genotype and lowest in QQ genotype. Paraoxonase and arylesterase activities were higher in LL and lower in MM genotypes of PON1 LM55 polymorphism. RQ and LM variants showed intermediate activities between respective homozygous. Elevated concentrations of triglycerides in cases correlate with QQ variant or the presence of M allele. Glucose levels were elevated in cases with QQ variant or with the presence of M allele. Cholesterol and LDL did not show variations in control and cases with any variant of both polymorphisms. HDL is lower in cases with respect to controls independently of genotypes. All differences were significant with p < 0.05.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38651
Fridman, Osvaldo; Gariglio Zappellini, Luis Osvaldo; Riviere, Stephanie; Porcile, Rafael; Fuchs, Alicia Graciela; et al.; Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia; Elsevier; Archivos de Cardiología de México; 86; 4; 10-2016; 350-357
1405-9940
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38651
identifier_str_mv Fridman, Osvaldo; Gariglio Zappellini, Luis Osvaldo; Riviere, Stephanie; Porcile, Rafael; Fuchs, Alicia Graciela; et al.; Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia; Elsevier; Archivos de Cardiología de México; 86; 4; 10-2016; 350-357
1405-9940
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.acmx.2016.08.001
info:eu-repo/semantics/altIdentifier/url/http://www.elsevier.es/es-revista-archivos-cardiologia-mexico-293-linkresolver-paraoxonase-1-gene-polymorphisms-enzyme-S1405994016300751
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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