Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
- Autores
- Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.
Fil: Bollmer, Jennifer L. University of Missouri; Estados Unidos. University of Wisconsin; Estados Unidos
Fil: Hull, Joshua M. University of California; Estados Unidos
Fil: Ernest, Holly B.. University of California; Estados Unidos
Fil: Sarasola, José Hernán. Estación Biológica de Doñana; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Parker, Patricia G.. University of Missouri; Estados Unidos - Materia
-
MAJOR HISTOCOMPATIBILITY COMPLEX
ISLAND SPECIES
GALAPAGOS HAWK
SWAINSON'S HAWK - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/81634
Ver los metadatos del registro completo
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Reduced MHC and neutral variation in the Galpagos hawk, an island endemicBollmer, Jennifer LHull, Joshua MErnest, Holly B.Sarasola, José HernánParker, Patricia G.MAJOR HISTOCOMPATIBILITY COMPLEXISLAND SPECIESGALAPAGOS HAWKSWAINSON'S HAWKhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.Fil: Bollmer, Jennifer L. University of Missouri; Estados Unidos. University of Wisconsin; Estados UnidosFil: Hull, Joshua M. University of California; Estados UnidosFil: Ernest, Holly B.. University of California; Estados UnidosFil: Sarasola, José Hernán. Estación Biológica de Doñana; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Parker, Patricia G.. University of Missouri; Estados UnidosBioMed Central2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81634Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.; Reduced MHC and neutral variation in the Galpagos hawk, an island endemic; BioMed Central; BMC Evolutionary Biology; 11; 1; 5-2011; 143-1541471-2148CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2148-11-143info:eu-repo/semantics/altIdentifier/url/https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-11-143info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:33Zoai:ri.conicet.gov.ar:11336/81634instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:33.29CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
title |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
spellingShingle |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic Bollmer, Jennifer L MAJOR HISTOCOMPATIBILITY COMPLEX ISLAND SPECIES GALAPAGOS HAWK SWAINSON'S HAWK |
title_short |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
title_full |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
title_fullStr |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
title_full_unstemmed |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
title_sort |
Reduced MHC and neutral variation in the Galpagos hawk, an island endemic |
dc.creator.none.fl_str_mv |
Bollmer, Jennifer L Hull, Joshua M Ernest, Holly B. Sarasola, José Hernán Parker, Patricia G. |
author |
Bollmer, Jennifer L |
author_facet |
Bollmer, Jennifer L Hull, Joshua M Ernest, Holly B. Sarasola, José Hernán Parker, Patricia G. |
author_role |
author |
author2 |
Hull, Joshua M Ernest, Holly B. Sarasola, José Hernán Parker, Patricia G. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
MAJOR HISTOCOMPATIBILITY COMPLEX ISLAND SPECIES GALAPAGOS HAWK SWAINSON'S HAWK |
topic |
MAJOR HISTOCOMPATIBILITY COMPLEX ISLAND SPECIES GALAPAGOS HAWK SWAINSON'S HAWK |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago. Fil: Bollmer, Jennifer L. University of Missouri; Estados Unidos. University of Wisconsin; Estados Unidos Fil: Hull, Joshua M. University of California; Estados Unidos Fil: Ernest, Holly B.. University of California; Estados Unidos Fil: Sarasola, José Hernán. Estación Biológica de Doñana; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina Fil: Parker, Patricia G.. University of Missouri; Estados Unidos |
description |
Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/81634 Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.; Reduced MHC and neutral variation in the Galpagos hawk, an island endemic; BioMed Central; BMC Evolutionary Biology; 11; 1; 5-2011; 143-154 1471-2148 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/81634 |
identifier_str_mv |
Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.; Reduced MHC and neutral variation in the Galpagos hawk, an island endemic; BioMed Central; BMC Evolutionary Biology; 11; 1; 5-2011; 143-154 1471-2148 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2148-11-143 info:eu-repo/semantics/altIdentifier/url/https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-11-143 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268801944518656 |
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13.13397 |