Reduced MHC and neutral variation in the Galpagos hawk, an island endemic

Autores
Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.
Fil: Bollmer, Jennifer L. University of Missouri; Estados Unidos. University of Wisconsin; Estados Unidos
Fil: Hull, Joshua M. University of California; Estados Unidos
Fil: Ernest, Holly B.. University of California; Estados Unidos
Fil: Sarasola, José Hernán. Estación Biológica de Doñana; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Parker, Patricia G.. University of Missouri; Estados Unidos
Materia
MAJOR HISTOCOMPATIBILITY COMPLEX
ISLAND SPECIES
GALAPAGOS HAWK
SWAINSON'S HAWK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81634

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network_name_str CONICET Digital (CONICET)
spelling Reduced MHC and neutral variation in the Galpagos hawk, an island endemicBollmer, Jennifer LHull, Joshua MErnest, Holly B.Sarasola, José HernánParker, Patricia G.MAJOR HISTOCOMPATIBILITY COMPLEXISLAND SPECIESGALAPAGOS HAWKSWAINSON'S HAWKhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.Fil: Bollmer, Jennifer L. University of Missouri; Estados Unidos. University of Wisconsin; Estados UnidosFil: Hull, Joshua M. University of California; Estados UnidosFil: Ernest, Holly B.. University of California; Estados UnidosFil: Sarasola, José Hernán. Estación Biológica de Doñana; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Parker, Patricia G.. University of Missouri; Estados UnidosBioMed Central2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81634Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.; Reduced MHC and neutral variation in the Galpagos hawk, an island endemic; BioMed Central; BMC Evolutionary Biology; 11; 1; 5-2011; 143-1541471-2148CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2148-11-143info:eu-repo/semantics/altIdentifier/url/https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-11-143info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:33Zoai:ri.conicet.gov.ar:11336/81634instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:33.29CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
title Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
spellingShingle Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
Bollmer, Jennifer L
MAJOR HISTOCOMPATIBILITY COMPLEX
ISLAND SPECIES
GALAPAGOS HAWK
SWAINSON'S HAWK
title_short Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
title_full Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
title_fullStr Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
title_full_unstemmed Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
title_sort Reduced MHC and neutral variation in the Galpagos hawk, an island endemic
dc.creator.none.fl_str_mv Bollmer, Jennifer L
Hull, Joshua M
Ernest, Holly B.
Sarasola, José Hernán
Parker, Patricia G.
author Bollmer, Jennifer L
author_facet Bollmer, Jennifer L
Hull, Joshua M
Ernest, Holly B.
Sarasola, José Hernán
Parker, Patricia G.
author_role author
author2 Hull, Joshua M
Ernest, Holly B.
Sarasola, José Hernán
Parker, Patricia G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv MAJOR HISTOCOMPATIBILITY COMPLEX
ISLAND SPECIES
GALAPAGOS HAWK
SWAINSON'S HAWK
topic MAJOR HISTOCOMPATIBILITY COMPLEX
ISLAND SPECIES
GALAPAGOS HAWK
SWAINSON'S HAWK
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.
Fil: Bollmer, Jennifer L. University of Missouri; Estados Unidos. University of Wisconsin; Estados Unidos
Fil: Hull, Joshua M. University of California; Estados Unidos
Fil: Ernest, Holly B.. University of California; Estados Unidos
Fil: Sarasola, José Hernán. Estación Biológica de Doñana; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Parker, Patricia G.. University of Missouri; Estados Unidos
description Background: Genes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galpagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni). Results: We amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galpagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galpagos hawk compared to the Swainson's hawk. Conclusions: The corresponding loss in neutral diversity suggests that the reduced variability present at Galpagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81634
Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.; Reduced MHC and neutral variation in the Galpagos hawk, an island endemic; BioMed Central; BMC Evolutionary Biology; 11; 1; 5-2011; 143-154
1471-2148
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81634
identifier_str_mv Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B.; Sarasola, José Hernán; Parker, Patricia G.; Reduced MHC and neutral variation in the Galpagos hawk, an island endemic; BioMed Central; BMC Evolutionary Biology; 11; 1; 5-2011; 143-154
1471-2148
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2148-11-143
info:eu-repo/semantics/altIdentifier/url/https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-11-143
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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