Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord

Autores
Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.
Fil: Buchet, Delphine. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Garcia, Corina Ileana. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Deboux, Cyrille. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Nait Oumesmar, Brahim. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Baron Van Evercooren, Anne. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Materia
Human Neural Progenitor Cells
Oligodendrocyte
Migration
Oligodendrogenesis
Remyelination
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12921
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12921
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cordBuchet, DelphineGarcia, Corina IleanaDeboux, CyrilleNait Oumesmar, BrahimBaron Van Evercooren, AnneHuman Neural Progenitor CellsOligodendrocyteMigrationOligodendrogenesisRemyelinationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.Fil: Buchet, Delphine. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Garcia, Corina Ileana. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Deboux, Cyrille. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Nait Oumesmar, Brahim. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaFil: Baron Van Evercooren, Anne. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; FranciaOxford University Press2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12921Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne; Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord; Oxford University Press; Brain; 134; 4; 4-2011; 1168-11830006-8950enginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awr030info:eu-repo/semantics/altIdentifier/doi/10.1093/brain/awr030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:07:02Zoai:ri.conicet.gov.ar:11336/12921instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:07:02.655CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
title Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
spellingShingle Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
Buchet, Delphine
Human Neural Progenitor Cells
Oligodendrocyte
Migration
Oligodendrogenesis
Remyelination
title_short Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
title_full Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
title_fullStr Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
title_full_unstemmed Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
title_sort Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord
dc.creator.none.fl_str_mv Buchet, Delphine
Garcia, Corina Ileana
Deboux, Cyrille
Nait Oumesmar, Brahim
Baron Van Evercooren, Anne
author Buchet, Delphine
author_facet Buchet, Delphine
Garcia, Corina Ileana
Deboux, Cyrille
Nait Oumesmar, Brahim
Baron Van Evercooren, Anne
author_role author
author2 Garcia, Corina Ileana
Deboux, Cyrille
Nait Oumesmar, Brahim
Baron Van Evercooren, Anne
author2_role author
author
author
author
dc.subject.none.fl_str_mv Human Neural Progenitor Cells
Oligodendrocyte
Migration
Oligodendrogenesis
Remyelination
topic Human Neural Progenitor Cells
Oligodendrocyte
Migration
Oligodendrogenesis
Remyelination
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.
Fil: Buchet, Delphine. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Garcia, Corina Ileana. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Deboux, Cyrille. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Nait Oumesmar, Brahim. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Baron Van Evercooren, Anne. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
description Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12921
Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne; Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord; Oxford University Press; Brain; 134; 4; 4-2011; 1168-1183
0006-8950
url http://hdl.handle.net/11336/12921
identifier_str_mv Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne; Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord; Oxford University Press; Brain; 134; 4; 4-2011; 1168-1183
0006-8950
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awr030
info:eu-repo/semantics/altIdentifier/doi/10.1093/brain/awr030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781379459678208
score 12.982451

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