Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications

Autores
Piguillem Palacios, Sofía Viviana; Gomez, Germán Ernesto; Tortella Fuentes, Gonzalo Rodrigo; Seabra, Amedea B.; Regiart, Daniel Matias Gaston; Messina, Germán Alejandro; Fernández Baldo, Martín Alejandro
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, we designed three promising platforms based on metal–organic frameworks(MOFs) to develop paper-based analytical devices (PADs) for biosensing applications. PADs havebecome increasingly popular in field sensing in recent years due to their portability, low cost, simplicity,efficiency, fast detection capability, excellent sensitivity, and selectivity. In addition, MOFsare excellent choices for developing highly sensitive and selective sensors due their versatility forfunctionalizing, structural stability, and capability to adsorb and desorb specific molecules by reversibleinteractions. These materials also offer the possibility to modify their structure and properties,making them highly versatile and adaptable to different environments and sensing needs. In thisresearch, we synthesized and characterized three different amino-functionalized MOFs: UiO-66-NH2 (Zr), MIL-125-NH2 (Ti), and MIL-101-NH2 (Fe). These MOFs were used to fabricate PADscapable of sensitive and portable monitoring of alkaline phosphatase (ALP) enzyme activity bylaser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significantpotential for integration into biosensor PADs, offering key properties that enhance their performanceand applicability in analytical chemistry and diagnostics.
Fil: Piguillem Palacios, Sofía Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Gomez, Germán Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Tortella Fuentes, Gonzalo Rodrigo. Universidad de La Frontera; Chile
Fil: Seabra, Amedea B.. Universidad Federal do Abc; Brasil
Fil: Regiart, Daniel Matias Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Messina, Germán Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
MOFs
BIOSENSING
FLUORESCENCE
PAPER ANALYTICAL DEVICE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/262629
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/262629
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection ApplicationsPiguillem Palacios, Sofía VivianaGomez, Germán ErnestoTortella Fuentes, Gonzalo RodrigoSeabra, Amedea B.Regiart, Daniel Matias GastonMessina, Germán AlejandroFernández Baldo, Martín AlejandroMOFsBIOSENSINGFLUORESCENCEPAPER ANALYTICAL DEVICEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this study, we designed three promising platforms based on metal–organic frameworks(MOFs) to develop paper-based analytical devices (PADs) for biosensing applications. PADs havebecome increasingly popular in field sensing in recent years due to their portability, low cost, simplicity,efficiency, fast detection capability, excellent sensitivity, and selectivity. In addition, MOFsare excellent choices for developing highly sensitive and selective sensors due their versatility forfunctionalizing, structural stability, and capability to adsorb and desorb specific molecules by reversibleinteractions. These materials also offer the possibility to modify their structure and properties,making them highly versatile and adaptable to different environments and sensing needs. In thisresearch, we synthesized and characterized three different amino-functionalized MOFs: UiO-66-NH2 (Zr), MIL-125-NH2 (Ti), and MIL-101-NH2 (Fe). These MOFs were used to fabricate PADscapable of sensitive and portable monitoring of alkaline phosphatase (ALP) enzyme activity bylaser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significantpotential for integration into biosensor PADs, offering key properties that enhance their performanceand applicability in analytical chemistry and diagnostics.Fil: Piguillem Palacios, Sofía Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Gomez, Germán Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Tortella Fuentes, Gonzalo Rodrigo. Universidad de La Frontera; ChileFil: Seabra, Amedea B.. Universidad Federal do Abc; BrasilFil: Regiart, Daniel Matias Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Messina, Germán Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaMultidisciplinary Digital Publishing Institute2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/262629Piguillem Palacios, Sofía Viviana; Gomez, Germán Ernesto; Tortella Fuentes, Gonzalo Rodrigo; Seabra, Amedea B.; Regiart, Daniel Matias Gaston; et al.; Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications; Multidisciplinary Digital Publishing Institute; Chemosensors; 12; 10; 10-2024; 208-2222227-9040CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2227-9040/12/10/208info:eu-repo/semantics/altIdentifier/doi/10.3390/chemosensors12100208info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:51Zoai:ri.conicet.gov.ar:11336/262629instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:51.417CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
title Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
spellingShingle Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
Piguillem Palacios, Sofía Viviana
MOFs
BIOSENSING
FLUORESCENCE
PAPER ANALYTICAL DEVICE
title_short Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
title_full Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
title_fullStr Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
title_full_unstemmed Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
title_sort Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications
dc.creator.none.fl_str_mv Piguillem Palacios, Sofía Viviana
Gomez, Germán Ernesto
Tortella Fuentes, Gonzalo Rodrigo
Seabra, Amedea B.
Regiart, Daniel Matias Gaston
Messina, Germán Alejandro
Fernández Baldo, Martín Alejandro
author Piguillem Palacios, Sofía Viviana
author_facet Piguillem Palacios, Sofía Viviana
Gomez, Germán Ernesto
Tortella Fuentes, Gonzalo Rodrigo
Seabra, Amedea B.
Regiart, Daniel Matias Gaston
Messina, Germán Alejandro
Fernández Baldo, Martín Alejandro
author_role author
author2 Gomez, Germán Ernesto
Tortella Fuentes, Gonzalo Rodrigo
Seabra, Amedea B.
Regiart, Daniel Matias Gaston
Messina, Germán Alejandro
Fernández Baldo, Martín Alejandro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MOFs
BIOSENSING
FLUORESCENCE
PAPER ANALYTICAL DEVICE
topic MOFs
BIOSENSING
FLUORESCENCE
PAPER ANALYTICAL DEVICE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this study, we designed three promising platforms based on metal–organic frameworks(MOFs) to develop paper-based analytical devices (PADs) for biosensing applications. PADs havebecome increasingly popular in field sensing in recent years due to their portability, low cost, simplicity,efficiency, fast detection capability, excellent sensitivity, and selectivity. In addition, MOFsare excellent choices for developing highly sensitive and selective sensors due their versatility forfunctionalizing, structural stability, and capability to adsorb and desorb specific molecules by reversibleinteractions. These materials also offer the possibility to modify their structure and properties,making them highly versatile and adaptable to different environments and sensing needs. In thisresearch, we synthesized and characterized three different amino-functionalized MOFs: UiO-66-NH2 (Zr), MIL-125-NH2 (Ti), and MIL-101-NH2 (Fe). These MOFs were used to fabricate PADscapable of sensitive and portable monitoring of alkaline phosphatase (ALP) enzyme activity bylaser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significantpotential for integration into biosensor PADs, offering key properties that enhance their performanceand applicability in analytical chemistry and diagnostics.
Fil: Piguillem Palacios, Sofía Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Gomez, Germán Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Tortella Fuentes, Gonzalo Rodrigo. Universidad de La Frontera; Chile
Fil: Seabra, Amedea B.. Universidad Federal do Abc; Brasil
Fil: Regiart, Daniel Matias Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Messina, Germán Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description In this study, we designed three promising platforms based on metal–organic frameworks(MOFs) to develop paper-based analytical devices (PADs) for biosensing applications. PADs havebecome increasingly popular in field sensing in recent years due to their portability, low cost, simplicity,efficiency, fast detection capability, excellent sensitivity, and selectivity. In addition, MOFsare excellent choices for developing highly sensitive and selective sensors due their versatility forfunctionalizing, structural stability, and capability to adsorb and desorb specific molecules by reversibleinteractions. These materials also offer the possibility to modify their structure and properties,making them highly versatile and adaptable to different environments and sensing needs. In thisresearch, we synthesized and characterized three different amino-functionalized MOFs: UiO-66-NH2 (Zr), MIL-125-NH2 (Ti), and MIL-101-NH2 (Fe). These MOFs were used to fabricate PADscapable of sensitive and portable monitoring of alkaline phosphatase (ALP) enzyme activity bylaser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significantpotential for integration into biosensor PADs, offering key properties that enhance their performanceand applicability in analytical chemistry and diagnostics.
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/262629
Piguillem Palacios, Sofía Viviana; Gomez, Germán Ernesto; Tortella Fuentes, Gonzalo Rodrigo; Seabra, Amedea B.; Regiart, Daniel Matias Gaston; et al.; Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications; Multidisciplinary Digital Publishing Institute; Chemosensors; 12; 10; 10-2024; 208-222
2227-9040
CONICET Digital
CONICET
url http://hdl.handle.net/11336/262629
identifier_str_mv Piguillem Palacios, Sofía Viviana; Gomez, Germán Ernesto; Tortella Fuentes, Gonzalo Rodrigo; Seabra, Amedea B.; Regiart, Daniel Matias Gaston; et al.; Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications; Multidisciplinary Digital Publishing Institute; Chemosensors; 12; 10; 10-2024; 208-222
2227-9040
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2227-9040/12/10/208
info:eu-repo/semantics/altIdentifier/doi/10.3390/chemosensors12100208
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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