Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1)
- Autores
- Sabini, Maria Carola; Cariddi, Laura Noelia; Escobar, Franco Matias; Aguilar, Juan Javier; Tonn, Carlos Eugenio; Contigiani de Minio, Marta Silvia; Sabini, Liliana Ines
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It has demonstrated “in vitro” antimicrobial activity exerted by extracts from Minthostachys verticillata (peperina). Objective: Investigate antiviral action of organic extracts of peperina against Herpes simplex virus. Experimental: Vero cells and Herpes simplex virus type 1 strain KOS were used. Aerial vegetal parts of plant were submitted to sequential extraction with n-hexane, chloroform and methanol for 48 h at room temperature. Extracts n-hexanic (N-HE), chloroformic (CE) and methanolic (ME) were obtained. They were added on cell monolayers, and incubated for 48 h at 37°C. Cell viability was determinated by Neutral Red uptake (NRU) after treatment of cells with different concentrations of extracts (10-1000 μg/ml). The same method was performed to evaluate antiviral action exerted by N-HE (100-250 μg/ml), CE (100-500 μg/ml) and ME (range 80-200 μg/ml). Results and discussion: The three extracts showed dose-dependent cytotoxic activity on Vero cells with CC50 values: 502 μg/ml for CE, 244 μg/ml for N-HE and 192 μg/ml for ME. The replication of Herpes simplex virus type 1 “in vitro” was inhibited by each extract at non cytotoxic concentrations. The extracts showed selectivity of action because all concentrations tested inhibited more than 60% of viral production. The results are promising for future natural therapy antiherpetic.
Fil: Sabini, Maria Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Cariddi, Laura Noelia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
Fil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Sabini, Liliana Ines. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina - Materia
-
MINTHOSTACHYS VERTICILLATA
CYTOTOXICITY
ANTIVIRAL ACTIVITY
ORGANIC EXTRACTS
HERPES SIMPLEX VIRUS
NEUTRAL RED UPTAKE ASSAY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/109722
Ver los metadatos del registro completo
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Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1)Sabini, Maria CarolaCariddi, Laura NoeliaEscobar, Franco MatiasAguilar, Juan JavierTonn, Carlos EugenioContigiani de Minio, Marta SilviaSabini, Liliana InesMINTHOSTACHYS VERTICILLATACYTOTOXICITYANTIVIRAL ACTIVITYORGANIC EXTRACTSHERPES SIMPLEX VIRUSNEUTRAL RED UPTAKE ASSAYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It has demonstrated “in vitro” antimicrobial activity exerted by extracts from Minthostachys verticillata (peperina). Objective: Investigate antiviral action of organic extracts of peperina against Herpes simplex virus. Experimental: Vero cells and Herpes simplex virus type 1 strain KOS were used. Aerial vegetal parts of plant were submitted to sequential extraction with n-hexane, chloroform and methanol for 48 h at room temperature. Extracts n-hexanic (N-HE), chloroformic (CE) and methanolic (ME) were obtained. They were added on cell monolayers, and incubated for 48 h at 37°C. Cell viability was determinated by Neutral Red uptake (NRU) after treatment of cells with different concentrations of extracts (10-1000 μg/ml). The same method was performed to evaluate antiviral action exerted by N-HE (100-250 μg/ml), CE (100-500 μg/ml) and ME (range 80-200 μg/ml). Results and discussion: The three extracts showed dose-dependent cytotoxic activity on Vero cells with CC50 values: 502 μg/ml for CE, 244 μg/ml for N-HE and 192 μg/ml for ME. The replication of Herpes simplex virus type 1 “in vitro” was inhibited by each extract at non cytotoxic concentrations. The extracts showed selectivity of action because all concentrations tested inhibited more than 60% of viral production. The results are promising for future natural therapy antiherpetic.Fil: Sabini, Maria Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Cariddi, Laura Noelia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; ArgentinaFil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaInstituto de Investigación de las Ciencias Exactas Físicas y Naturales2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/109722Sabini, Maria Carola; Cariddi, Laura Noelia; Escobar, Franco Matias; Aguilar, Juan Javier; Tonn, Carlos Eugenio; et al.; Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1); Instituto de Investigación de las Ciencias Exactas Físicas y Naturales; Molecular Medicinal Chemistry; 21; 1-2010; 84-871666-888XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.idecefyn.com.ar/MMC21PDF/vol_21__january.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:47Zoai:ri.conicet.gov.ar:11336/109722instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:48.084CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
title |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
spellingShingle |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) Sabini, Maria Carola MINTHOSTACHYS VERTICILLATA CYTOTOXICITY ANTIVIRAL ACTIVITY ORGANIC EXTRACTS HERPES SIMPLEX VIRUS NEUTRAL RED UPTAKE ASSAY |
title_short |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
title_full |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
title_fullStr |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
title_full_unstemmed |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
title_sort |
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1) |
dc.creator.none.fl_str_mv |
Sabini, Maria Carola Cariddi, Laura Noelia Escobar, Franco Matias Aguilar, Juan Javier Tonn, Carlos Eugenio Contigiani de Minio, Marta Silvia Sabini, Liliana Ines |
author |
Sabini, Maria Carola |
author_facet |
Sabini, Maria Carola Cariddi, Laura Noelia Escobar, Franco Matias Aguilar, Juan Javier Tonn, Carlos Eugenio Contigiani de Minio, Marta Silvia Sabini, Liliana Ines |
author_role |
author |
author2 |
Cariddi, Laura Noelia Escobar, Franco Matias Aguilar, Juan Javier Tonn, Carlos Eugenio Contigiani de Minio, Marta Silvia Sabini, Liliana Ines |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
MINTHOSTACHYS VERTICILLATA CYTOTOXICITY ANTIVIRAL ACTIVITY ORGANIC EXTRACTS HERPES SIMPLEX VIRUS NEUTRAL RED UPTAKE ASSAY |
topic |
MINTHOSTACHYS VERTICILLATA CYTOTOXICITY ANTIVIRAL ACTIVITY ORGANIC EXTRACTS HERPES SIMPLEX VIRUS NEUTRAL RED UPTAKE ASSAY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
It has demonstrated “in vitro” antimicrobial activity exerted by extracts from Minthostachys verticillata (peperina). Objective: Investigate antiviral action of organic extracts of peperina against Herpes simplex virus. Experimental: Vero cells and Herpes simplex virus type 1 strain KOS were used. Aerial vegetal parts of plant were submitted to sequential extraction with n-hexane, chloroform and methanol for 48 h at room temperature. Extracts n-hexanic (N-HE), chloroformic (CE) and methanolic (ME) were obtained. They were added on cell monolayers, and incubated for 48 h at 37°C. Cell viability was determinated by Neutral Red uptake (NRU) after treatment of cells with different concentrations of extracts (10-1000 μg/ml). The same method was performed to evaluate antiviral action exerted by N-HE (100-250 μg/ml), CE (100-500 μg/ml) and ME (range 80-200 μg/ml). Results and discussion: The three extracts showed dose-dependent cytotoxic activity on Vero cells with CC50 values: 502 μg/ml for CE, 244 μg/ml for N-HE and 192 μg/ml for ME. The replication of Herpes simplex virus type 1 “in vitro” was inhibited by each extract at non cytotoxic concentrations. The extracts showed selectivity of action because all concentrations tested inhibited more than 60% of viral production. The results are promising for future natural therapy antiherpetic. Fil: Sabini, Maria Carola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Cariddi, Laura Noelia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina Fil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina Fil: Sabini, Liliana Ines. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina |
description |
It has demonstrated “in vitro” antimicrobial activity exerted by extracts from Minthostachys verticillata (peperina). Objective: Investigate antiviral action of organic extracts of peperina against Herpes simplex virus. Experimental: Vero cells and Herpes simplex virus type 1 strain KOS were used. Aerial vegetal parts of plant were submitted to sequential extraction with n-hexane, chloroform and methanol for 48 h at room temperature. Extracts n-hexanic (N-HE), chloroformic (CE) and methanolic (ME) were obtained. They were added on cell monolayers, and incubated for 48 h at 37°C. Cell viability was determinated by Neutral Red uptake (NRU) after treatment of cells with different concentrations of extracts (10-1000 μg/ml). The same method was performed to evaluate antiviral action exerted by N-HE (100-250 μg/ml), CE (100-500 μg/ml) and ME (range 80-200 μg/ml). Results and discussion: The three extracts showed dose-dependent cytotoxic activity on Vero cells with CC50 values: 502 μg/ml for CE, 244 μg/ml for N-HE and 192 μg/ml for ME. The replication of Herpes simplex virus type 1 “in vitro” was inhibited by each extract at non cytotoxic concentrations. The extracts showed selectivity of action because all concentrations tested inhibited more than 60% of viral production. The results are promising for future natural therapy antiherpetic. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/109722 Sabini, Maria Carola; Cariddi, Laura Noelia; Escobar, Franco Matias; Aguilar, Juan Javier; Tonn, Carlos Eugenio; et al.; Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1); Instituto de Investigación de las Ciencias Exactas Físicas y Naturales; Molecular Medicinal Chemistry; 21; 1-2010; 84-87 1666-888X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/109722 |
identifier_str_mv |
Sabini, Maria Carola; Cariddi, Laura Noelia; Escobar, Franco Matias; Aguilar, Juan Javier; Tonn, Carlos Eugenio; et al.; Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1); Instituto de Investigación de las Ciencias Exactas Físicas y Naturales; Molecular Medicinal Chemistry; 21; 1-2010; 84-87 1666-888X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.idecefyn.com.ar/MMC21PDF/vol_21__january.htm |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Instituto de Investigación de las Ciencias Exactas Físicas y Naturales |
publisher.none.fl_str_mv |
Instituto de Investigación de las Ciencias Exactas Físicas y Naturales |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613980014772224 |
score |
13.070432 |