Splicing regulation by long noncoding RNAs

Autores
Romero Barrios, Natali; Legascue, María Florencia; Benhamed, Moussa; Ariel, Federico Damian; Crespi, Martin
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs have been shown to play a crucial role in the regulation of alternative splicing in response to several stimuli or during disease. In this review, we focus on recent discoveries linking gene regulation by alternative splicing and its modulation by long and small ncRNAs.
Fil: Romero Barrios, Natali. Universite Paris-sud Xi;
Fil: Legascue, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Benhamed, Moussa. Universite Paris-sud Xi;
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Crespi, Martin. Universite Paris-sud Xi;
Materia
splicing regulation
LNCsRNAs
epigenetics
alternative splicing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86689
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Splicing regulation by long noncoding RNAsRomero Barrios, NataliLegascue, María FlorenciaBenhamed, MoussaAriel, Federico DamianCrespi, Martinsplicing regulationLNCsRNAsepigeneticsalternative splicinghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs have been shown to play a crucial role in the regulation of alternative splicing in response to several stimuli or during disease. In this review, we focus on recent discoveries linking gene regulation by alternative splicing and its modulation by long and small ncRNAs.Fil: Romero Barrios, Natali. Universite Paris-sud Xi;Fil: Legascue, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Benhamed, Moussa. Universite Paris-sud Xi;Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Crespi, Martin. Universite Paris-sud Xi;Oxford University Press2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86689Romero Barrios, Natali; Legascue, María Florencia; Benhamed, Moussa; Ariel, Federico Damian; Crespi, Martin; Splicing regulation by long noncoding RNAs; Oxford University Press; Nucleic Acids Research; 46; 5; 2-2018; 2169-21840305-10481362-4962CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky095/4841659info:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gky095info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:51Zoai:ri.conicet.gov.ar:11336/86689instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:51.912CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Splicing regulation by long noncoding RNAs
title Splicing regulation by long noncoding RNAs
spellingShingle Splicing regulation by long noncoding RNAs
Romero Barrios, Natali
splicing regulation
LNCsRNAs
epigenetics
alternative splicing
title_short Splicing regulation by long noncoding RNAs
title_full Splicing regulation by long noncoding RNAs
title_fullStr Splicing regulation by long noncoding RNAs
title_full_unstemmed Splicing regulation by long noncoding RNAs
title_sort Splicing regulation by long noncoding RNAs
dc.creator.none.fl_str_mv Romero Barrios, Natali
Legascue, María Florencia
Benhamed, Moussa
Ariel, Federico Damian
Crespi, Martin
author Romero Barrios, Natali
author_facet Romero Barrios, Natali
Legascue, María Florencia
Benhamed, Moussa
Ariel, Federico Damian
Crespi, Martin
author_role author
author2 Legascue, María Florencia
Benhamed, Moussa
Ariel, Federico Damian
Crespi, Martin
author2_role author
author
author
author
dc.subject.none.fl_str_mv splicing regulation
LNCsRNAs
epigenetics
alternative splicing
topic splicing regulation
LNCsRNAs
epigenetics
alternative splicing
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs have been shown to play a crucial role in the regulation of alternative splicing in response to several stimuli or during disease. In this review, we focus on recent discoveries linking gene regulation by alternative splicing and its modulation by long and small ncRNAs.
Fil: Romero Barrios, Natali. Universite Paris-sud Xi;
Fil: Legascue, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Benhamed, Moussa. Universite Paris-sud Xi;
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Crespi, Martin. Universite Paris-sud Xi;
description Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs have been shown to play a crucial role in the regulation of alternative splicing in response to several stimuli or during disease. In this review, we focus on recent discoveries linking gene regulation by alternative splicing and its modulation by long and small ncRNAs.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86689
Romero Barrios, Natali; Legascue, María Florencia; Benhamed, Moussa; Ariel, Federico Damian; Crespi, Martin; Splicing regulation by long noncoding RNAs; Oxford University Press; Nucleic Acids Research; 46; 5; 2-2018; 2169-2184
0305-1048
1362-4962
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86689
identifier_str_mv Romero Barrios, Natali; Legascue, María Florencia; Benhamed, Moussa; Ariel, Federico Damian; Crespi, Martin; Splicing regulation by long noncoding RNAs; Oxford University Press; Nucleic Acids Research; 46; 5; 2-2018; 2169-2184
0305-1048
1362-4962
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky095/4841659
info:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gky095
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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