Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery

Autores
Salazar Vega, Jorge L.; Levin, Gloria Mabel; Sanso, Elsa Gabriela; Vieites, Ana; Gomez, Reynaldo Manuel; Barontini, Marta Beatriz
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective : The objective of this study is to present the clinical findings and outcome of a large cohort of pregnant women with pheochromocytoma (PHEO) with the aim to contribute to the better recognition, detection and management of pregnancy-related PHEO in the population of pregnant patients with hypertension. Methods : This is a longitudinal follow up of a single cohort of 15 patients aged 19?40 years with PHEO associated with pregnancy. Urinary catecholamines and vanillylmandelic acid (VMA) were analysed. Ret protooncogene,SDHB and VHL mutations were determined in germline DNA from seven women using PCR followed by direct sequencing. Results : During pregnancy, all women presented typical features of catecholamines excess. Nevertheless, biochemical diagnosis was performed only in four out of 15 cases during pregnancy and postpartum in the remaining 11. Paroxysmal hypertension was the predominant pattern. Urinary catecholamines and/or VMA were increased in all patients. Tumours were adrenal in 13 patients and extraadrenal in two. Mutations in the Ret proto-oncogene were found in four patients, in the VHL gene in one and in the SDHB gene in one.Antihypertensive treatment resulted in effective control of blood pressure and all women survived. In the group of women diagnosed postpartum, one foetus demised. Newborns from mothers receiving adequate treatment survived. One woman left the hospital after caesarean section but before PHEO surgery became pregnant again and this gestation ended with maternal-foetal dead. Conclusion : A high index of suspicion in all pregnant women presenting hypertension mainly paroxystic during any gestational phase and/or a history of familial PHEO are the keys to disclose this important diagnosis.
Fil: Salazar Vega, Jorge L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Sanso, Elsa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Vieites, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas Gral. San Martín. División Endocrinologia; Argentina
Fil: Barontini, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Materia
Catecholamines
Hypertension
Pheochromocytoma
Pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8147
Acceder
id CONICETDig_93d79b772cd6d6d185984cfbedc4439d
oai_identifier_str oai:ri.conicet.gov.ar:11336/8147
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after deliverySalazar Vega, Jorge L.Levin, Gloria MabelSanso, Elsa GabrielaVieites, AnaGomez, Reynaldo ManuelBarontini, Marta BeatrizCatecholaminesHypertensionPheochromocytomaPregnancyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective : The objective of this study is to present the clinical findings and outcome of a large cohort of pregnant women with pheochromocytoma (PHEO) with the aim to contribute to the better recognition, detection and management of pregnancy-related PHEO in the population of pregnant patients with hypertension. Methods : This is a longitudinal follow up of a single cohort of 15 patients aged 19?40 years with PHEO associated with pregnancy. Urinary catecholamines and vanillylmandelic acid (VMA) were analysed. Ret protooncogene,SDHB and VHL mutations were determined in germline DNA from seven women using PCR followed by direct sequencing. Results : During pregnancy, all women presented typical features of catecholamines excess. Nevertheless, biochemical diagnosis was performed only in four out of 15 cases during pregnancy and postpartum in the remaining 11. Paroxysmal hypertension was the predominant pattern. Urinary catecholamines and/or VMA were increased in all patients. Tumours were adrenal in 13 patients and extraadrenal in two. Mutations in the Ret proto-oncogene were found in four patients, in the VHL gene in one and in the SDHB gene in one.Antihypertensive treatment resulted in effective control of blood pressure and all women survived. In the group of women diagnosed postpartum, one foetus demised. Newborns from mothers receiving adequate treatment survived. One woman left the hospital after caesarean section but before PHEO surgery became pregnant again and this gestation ended with maternal-foetal dead. Conclusion : A high index of suspicion in all pregnant women presenting hypertension mainly paroxystic during any gestational phase and/or a history of familial PHEO are the keys to disclose this important diagnosis.Fil: Salazar Vega, Jorge L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Sanso, Elsa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Vieites, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas Gral. San Martín. División Endocrinologia; ArgentinaFil: Barontini, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaLippincott Williams2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8147Salazar Vega, Jorge L.; Levin, Gloria Mabel; Sanso, Elsa Gabriela; Vieites, Ana; Gomez, Reynaldo Manuel; et al.; Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery; Lippincott Williams; Journal Of Hypertension; 32; 7; 7-2014; 1458-14630263-6352enginfo:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/jhypertension/pages/articleviewer.aspx?year=2014&issue=07000&article=00017&type=abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1097/HJH.0000000000000215info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:55Zoai:ri.conicet.gov.ar:11336/8147instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:55.453CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
title Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
spellingShingle Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
Salazar Vega, Jorge L.
Catecholamines
Hypertension
Pheochromocytoma
Pregnancy
title_short Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
title_full Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
title_fullStr Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
title_full_unstemmed Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
title_sort Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery
dc.creator.none.fl_str_mv Salazar Vega, Jorge L.
Levin, Gloria Mabel
Sanso, Elsa Gabriela
Vieites, Ana
Gomez, Reynaldo Manuel
Barontini, Marta Beatriz
author Salazar Vega, Jorge L.
author_facet Salazar Vega, Jorge L.
Levin, Gloria Mabel
Sanso, Elsa Gabriela
Vieites, Ana
Gomez, Reynaldo Manuel
Barontini, Marta Beatriz
author_role author
author2 Levin, Gloria Mabel
Sanso, Elsa Gabriela
Vieites, Ana
Gomez, Reynaldo Manuel
Barontini, Marta Beatriz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Catecholamines
Hypertension
Pheochromocytoma
Pregnancy
topic Catecholamines
Hypertension
Pheochromocytoma
Pregnancy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective : The objective of this study is to present the clinical findings and outcome of a large cohort of pregnant women with pheochromocytoma (PHEO) with the aim to contribute to the better recognition, detection and management of pregnancy-related PHEO in the population of pregnant patients with hypertension. Methods : This is a longitudinal follow up of a single cohort of 15 patients aged 19?40 years with PHEO associated with pregnancy. Urinary catecholamines and vanillylmandelic acid (VMA) were analysed. Ret protooncogene,SDHB and VHL mutations were determined in germline DNA from seven women using PCR followed by direct sequencing. Results : During pregnancy, all women presented typical features of catecholamines excess. Nevertheless, biochemical diagnosis was performed only in four out of 15 cases during pregnancy and postpartum in the remaining 11. Paroxysmal hypertension was the predominant pattern. Urinary catecholamines and/or VMA were increased in all patients. Tumours were adrenal in 13 patients and extraadrenal in two. Mutations in the Ret proto-oncogene were found in four patients, in the VHL gene in one and in the SDHB gene in one.Antihypertensive treatment resulted in effective control of blood pressure and all women survived. In the group of women diagnosed postpartum, one foetus demised. Newborns from mothers receiving adequate treatment survived. One woman left the hospital after caesarean section but before PHEO surgery became pregnant again and this gestation ended with maternal-foetal dead. Conclusion : A high index of suspicion in all pregnant women presenting hypertension mainly paroxystic during any gestational phase and/or a history of familial PHEO are the keys to disclose this important diagnosis.
Fil: Salazar Vega, Jorge L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Sanso, Elsa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Vieites, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas Gral. San Martín. División Endocrinologia; Argentina
Fil: Barontini, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
description Objective : The objective of this study is to present the clinical findings and outcome of a large cohort of pregnant women with pheochromocytoma (PHEO) with the aim to contribute to the better recognition, detection and management of pregnancy-related PHEO in the population of pregnant patients with hypertension. Methods : This is a longitudinal follow up of a single cohort of 15 patients aged 19?40 years with PHEO associated with pregnancy. Urinary catecholamines and vanillylmandelic acid (VMA) were analysed. Ret protooncogene,SDHB and VHL mutations were determined in germline DNA from seven women using PCR followed by direct sequencing. Results : During pregnancy, all women presented typical features of catecholamines excess. Nevertheless, biochemical diagnosis was performed only in four out of 15 cases during pregnancy and postpartum in the remaining 11. Paroxysmal hypertension was the predominant pattern. Urinary catecholamines and/or VMA were increased in all patients. Tumours were adrenal in 13 patients and extraadrenal in two. Mutations in the Ret proto-oncogene were found in four patients, in the VHL gene in one and in the SDHB gene in one.Antihypertensive treatment resulted in effective control of blood pressure and all women survived. In the group of women diagnosed postpartum, one foetus demised. Newborns from mothers receiving adequate treatment survived. One woman left the hospital after caesarean section but before PHEO surgery became pregnant again and this gestation ended with maternal-foetal dead. Conclusion : A high index of suspicion in all pregnant women presenting hypertension mainly paroxystic during any gestational phase and/or a history of familial PHEO are the keys to disclose this important diagnosis.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8147
Salazar Vega, Jorge L.; Levin, Gloria Mabel; Sanso, Elsa Gabriela; Vieites, Ana; Gomez, Reynaldo Manuel; et al.; Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery; Lippincott Williams; Journal Of Hypertension; 32; 7; 7-2014; 1458-1463
0263-6352
url http://hdl.handle.net/11336/8147
identifier_str_mv Salazar Vega, Jorge L.; Levin, Gloria Mabel; Sanso, Elsa Gabriela; Vieites, Ana; Gomez, Reynaldo Manuel; et al.; Pheochromocytoma associatedwith pregnancy: unexpected favourable outcome in patients diagnosed after delivery; Lippincott Williams; Journal Of Hypertension; 32; 7; 7-2014; 1458-1463
0263-6352
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/jhypertension/pages/articleviewer.aspx?year=2014&issue=07000&article=00017&type=abstract
info:eu-repo/semantics/altIdentifier/doi/10.1097/HJH.0000000000000215
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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