Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels

Autores
Quignard , Sandrine; Copello, Guillermo Javier; Aimé, Carole; Bataille, Isabelle; Hélary, Christophe; Desimone, Martín Federico; Coradin, Thibaud
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A buffer-mediated gelation route for collagen hydrogels that allows the formation of homogeneous composite and hybrid materials with various silica sources (i.e., colloidal silica and soluble silicates) at high concentration (up to 25X10-3 M) is described. Most significant improvement in rheological properties and proliferation of primary adult human dermal fibroblasts was obtained for the silicate-based hybrid materials. A similar trend was observed in composite materials incorporating 14nm SiO2 nanoparticles, although to a much lesser extent, whereas larger colloids (80 and 390 nm) did not significantly impact mechanical stability and cell behavior. Modification of 80nm particles surface with amine groups weakens the collagen-mineral interface, resulting in the decrease of material stability and leading to particle aggregation during the course of cell proliferation experiments.
Fil: Quignard , Sandrine. Université Pierre et Marie Curie; Francia
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Aimé, Carole. Université Pierre et Marie Curie; Francia
Fil: Bataille, Isabelle. Centre National de la Recherche Scientifique; Francia
Fil: Hélary, Christophe. Université Pierre et Marie Curie; Francia
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Coradin, Thibaud. Université Pierre et Marie Curie; Francia
Materia
silicification
biological properties
collagen hydrogels
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/131806
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogelsQuignard , SandrineCopello, Guillermo JavierAimé, CaroleBataille, IsabelleHélary, ChristopheDesimone, Martín FedericoCoradin, Thibaudsilicificationbiological propertiescollagen hydrogelshttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3A buffer-mediated gelation route for collagen hydrogels that allows the formation of homogeneous composite and hybrid materials with various silica sources (i.e., colloidal silica and soluble silicates) at high concentration (up to 25X10-3 M) is described. Most significant improvement in rheological properties and proliferation of primary adult human dermal fibroblasts was obtained for the silicate-based hybrid materials. A similar trend was observed in composite materials incorporating 14nm SiO2 nanoparticles, although to a much lesser extent, whereas larger colloids (80 and 390 nm) did not significantly impact mechanical stability and cell behavior. Modification of 80nm particles surface with amine groups weakens the collagen-mineral interface, resulting in the decrease of material stability and leading to particle aggregation during the course of cell proliferation experiments.Fil: Quignard , Sandrine. Université Pierre et Marie Curie; FranciaFil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Aimé, Carole. Université Pierre et Marie Curie; FranciaFil: Bataille, Isabelle. Centre National de la Recherche Scientifique; FranciaFil: Hélary, Christophe. Université Pierre et Marie Curie; FranciaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Coradin, Thibaud. Université Pierre et Marie Curie; FranciaWiley VCH Verlag2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131806Quignard , Sandrine; Copello, Guillermo Javier; Aimé, Carole; Bataille, Isabelle; Hélary, Christophe; et al.; Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels; Wiley VCH Verlag; Advanced Engineering Materials (print); 14; 3; 3-2012; 51-551438-1656CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/adem.201180063info:eu-repo/semantics/altIdentifier/doi/10.1002/adem.201180063info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:58:33Zoai:ri.conicet.gov.ar:11336/131806instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:58:33.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
title Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
spellingShingle Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
Quignard , Sandrine
silicification
biological properties
collagen hydrogels
title_short Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
title_full Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
title_fullStr Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
title_full_unstemmed Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
title_sort Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels
dc.creator.none.fl_str_mv Quignard , Sandrine
Copello, Guillermo Javier
Aimé, Carole
Bataille, Isabelle
Hélary, Christophe
Desimone, Martín Federico
Coradin, Thibaud
author Quignard , Sandrine
author_facet Quignard , Sandrine
Copello, Guillermo Javier
Aimé, Carole
Bataille, Isabelle
Hélary, Christophe
Desimone, Martín Federico
Coradin, Thibaud
author_role author
author2 Copello, Guillermo Javier
Aimé, Carole
Bataille, Isabelle
Hélary, Christophe
Desimone, Martín Federico
Coradin, Thibaud
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv silicification
biological properties
collagen hydrogels
topic silicification
biological properties
collagen hydrogels
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A buffer-mediated gelation route for collagen hydrogels that allows the formation of homogeneous composite and hybrid materials with various silica sources (i.e., colloidal silica and soluble silicates) at high concentration (up to 25X10-3 M) is described. Most significant improvement in rheological properties and proliferation of primary adult human dermal fibroblasts was obtained for the silicate-based hybrid materials. A similar trend was observed in composite materials incorporating 14nm SiO2 nanoparticles, although to a much lesser extent, whereas larger colloids (80 and 390 nm) did not significantly impact mechanical stability and cell behavior. Modification of 80nm particles surface with amine groups weakens the collagen-mineral interface, resulting in the decrease of material stability and leading to particle aggregation during the course of cell proliferation experiments.
Fil: Quignard , Sandrine. Université Pierre et Marie Curie; Francia
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Aimé, Carole. Université Pierre et Marie Curie; Francia
Fil: Bataille, Isabelle. Centre National de la Recherche Scientifique; Francia
Fil: Hélary, Christophe. Université Pierre et Marie Curie; Francia
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Coradin, Thibaud. Université Pierre et Marie Curie; Francia
description A buffer-mediated gelation route for collagen hydrogels that allows the formation of homogeneous composite and hybrid materials with various silica sources (i.e., colloidal silica and soluble silicates) at high concentration (up to 25X10-3 M) is described. Most significant improvement in rheological properties and proliferation of primary adult human dermal fibroblasts was obtained for the silicate-based hybrid materials. A similar trend was observed in composite materials incorporating 14nm SiO2 nanoparticles, although to a much lesser extent, whereas larger colloids (80 and 390 nm) did not significantly impact mechanical stability and cell behavior. Modification of 80nm particles surface with amine groups weakens the collagen-mineral interface, resulting in the decrease of material stability and leading to particle aggregation during the course of cell proliferation experiments.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/131806
Quignard , Sandrine; Copello, Guillermo Javier; Aimé, Carole; Bataille, Isabelle; Hélary, Christophe; et al.; Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels; Wiley VCH Verlag; Advanced Engineering Materials (print); 14; 3; 3-2012; 51-55
1438-1656
CONICET Digital
CONICET
url http://hdl.handle.net/11336/131806
identifier_str_mv Quignard , Sandrine; Copello, Guillermo Javier; Aimé, Carole; Bataille, Isabelle; Hélary, Christophe; et al.; Influence of silicification on the structural and biological properties of buffer-mediated collagen hydrogels; Wiley VCH Verlag; Advanced Engineering Materials (print); 14; 3; 3-2012; 51-55
1438-1656
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/adem.201180063
info:eu-repo/semantics/altIdentifier/doi/10.1002/adem.201180063
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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