Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention
- Autores
- Alvarez, Gisela Solange; Hélary, Christophe; Mebert, Andrea Mathilde; Wang, Xiaolin; Coradin, Thibaud; Desimone, Martín Federico
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Silica–collagen type I nanocomposite hydrogels are evaluated as medicated dressings to prevent infection in chronic wounds. Two antibiotics, gentamicin and rifamycin, are encapsulated in a single step within plain silica nanoparticles. Their antimicrobial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus is assessed. Gentamycin-loaded 500 nm particles can be immobilized at high silica dose in concentrated collagen hydrogels without modifying their fibrillar structure or impacting on their rheological behavior and increases their proteolytic stability. Gentamicin release from the nanocomposites is sustained over 7 days, offering an unparalleled prolonged antibacterial activity. Particle immobilization also decreases their cytotoxicity towards surface-seeded fibroblast cells. Rifamycin-loaded 100 nm particles significantly alter the collagen hydrogel structure at high silica doses. The thus-obtained nanocomposites show no antibacterial efficiency, due to strong adsorption of rifamycin on collagen fibers. The complex interplay of interactions between drugs, silica and collagen is a key factor regulating the properties of these composite hydrogels as antibiotic-delivering biological dressings and must be taken into account for future extension to other wound healing agents.
Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Hélary, Christophe. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Mebert, Andrea Mathilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Wang, Xiaolin. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Coradin, Thibaud. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina - Materia
-
Antibiotic
Silica Nanoparticle
Collagen
Drug Release - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/18494
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection preventionAlvarez, Gisela SolangeHélary, ChristopheMebert, Andrea MathildeWang, XiaolinCoradin, ThibaudDesimone, Martín FedericoAntibioticSilica NanoparticleCollagenDrug Releasehttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Silica–collagen type I nanocomposite hydrogels are evaluated as medicated dressings to prevent infection in chronic wounds. Two antibiotics, gentamicin and rifamycin, are encapsulated in a single step within plain silica nanoparticles. Their antimicrobial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus is assessed. Gentamycin-loaded 500 nm particles can be immobilized at high silica dose in concentrated collagen hydrogels without modifying their fibrillar structure or impacting on their rheological behavior and increases their proteolytic stability. Gentamicin release from the nanocomposites is sustained over 7 days, offering an unparalleled prolonged antibacterial activity. Particle immobilization also decreases their cytotoxicity towards surface-seeded fibroblast cells. Rifamycin-loaded 100 nm particles significantly alter the collagen hydrogel structure at high silica doses. The thus-obtained nanocomposites show no antibacterial efficiency, due to strong adsorption of rifamycin on collagen fibers. The complex interplay of interactions between drugs, silica and collagen is a key factor regulating the properties of these composite hydrogels as antibiotic-delivering biological dressings and must be taken into account for future extension to other wound healing agents.Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Hélary, Christophe. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; FranciaFil: Mebert, Andrea Mathilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Wang, Xiaolin. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; FranciaFil: Coradin, Thibaud. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; FranciaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaRoyal Society of Chemistry2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18494Alvarez, Gisela Solange; Hélary, Christophe; Mebert, Andrea Mathilde; Wang, Xiaolin; Coradin, Thibaud; et al.; Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention; Royal Society of Chemistry; Journal of Materials Chemistry B; 2; 29; 7-2014; 4660-46702050-750XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c4tb00327f#!divAbstractinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C4TB00327Finfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:19Zoai:ri.conicet.gov.ar:11336/18494instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:19.55CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
title |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
spellingShingle |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention Alvarez, Gisela Solange Antibiotic Silica Nanoparticle Collagen Drug Release |
title_short |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
title_full |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
title_fullStr |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
title_full_unstemmed |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
title_sort |
Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention |
dc.creator.none.fl_str_mv |
Alvarez, Gisela Solange Hélary, Christophe Mebert, Andrea Mathilde Wang, Xiaolin Coradin, Thibaud Desimone, Martín Federico |
author |
Alvarez, Gisela Solange |
author_facet |
Alvarez, Gisela Solange Hélary, Christophe Mebert, Andrea Mathilde Wang, Xiaolin Coradin, Thibaud Desimone, Martín Federico |
author_role |
author |
author2 |
Hélary, Christophe Mebert, Andrea Mathilde Wang, Xiaolin Coradin, Thibaud Desimone, Martín Federico |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Antibiotic Silica Nanoparticle Collagen Drug Release |
topic |
Antibiotic Silica Nanoparticle Collagen Drug Release |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Silica–collagen type I nanocomposite hydrogels are evaluated as medicated dressings to prevent infection in chronic wounds. Two antibiotics, gentamicin and rifamycin, are encapsulated in a single step within plain silica nanoparticles. Their antimicrobial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus is assessed. Gentamycin-loaded 500 nm particles can be immobilized at high silica dose in concentrated collagen hydrogels without modifying their fibrillar structure or impacting on their rheological behavior and increases their proteolytic stability. Gentamicin release from the nanocomposites is sustained over 7 days, offering an unparalleled prolonged antibacterial activity. Particle immobilization also decreases their cytotoxicity towards surface-seeded fibroblast cells. Rifamycin-loaded 100 nm particles significantly alter the collagen hydrogel structure at high silica doses. The thus-obtained nanocomposites show no antibacterial efficiency, due to strong adsorption of rifamycin on collagen fibers. The complex interplay of interactions between drugs, silica and collagen is a key factor regulating the properties of these composite hydrogels as antibiotic-delivering biological dressings and must be taken into account for future extension to other wound healing agents. Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Hélary, Christophe. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Mebert, Andrea Mathilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Wang, Xiaolin. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Coradin, Thibaud. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina |
description |
Silica–collagen type I nanocomposite hydrogels are evaluated as medicated dressings to prevent infection in chronic wounds. Two antibiotics, gentamicin and rifamycin, are encapsulated in a single step within plain silica nanoparticles. Their antimicrobial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus is assessed. Gentamycin-loaded 500 nm particles can be immobilized at high silica dose in concentrated collagen hydrogels without modifying their fibrillar structure or impacting on their rheological behavior and increases their proteolytic stability. Gentamicin release from the nanocomposites is sustained over 7 days, offering an unparalleled prolonged antibacterial activity. Particle immobilization also decreases their cytotoxicity towards surface-seeded fibroblast cells. Rifamycin-loaded 100 nm particles significantly alter the collagen hydrogel structure at high silica doses. The thus-obtained nanocomposites show no antibacterial efficiency, due to strong adsorption of rifamycin on collagen fibers. The complex interplay of interactions between drugs, silica and collagen is a key factor regulating the properties of these composite hydrogels as antibiotic-delivering biological dressings and must be taken into account for future extension to other wound healing agents. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/18494 Alvarez, Gisela Solange; Hélary, Christophe; Mebert, Andrea Mathilde; Wang, Xiaolin; Coradin, Thibaud; et al.; Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention; Royal Society of Chemistry; Journal of Materials Chemistry B; 2; 29; 7-2014; 4660-4670 2050-750X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/18494 |
identifier_str_mv |
Alvarez, Gisela Solange; Hélary, Christophe; Mebert, Andrea Mathilde; Wang, Xiaolin; Coradin, Thibaud; et al.; Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention; Royal Society of Chemistry; Journal of Materials Chemistry B; 2; 29; 7-2014; 4660-4670 2050-750X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c4tb00327f#!divAbstract info:eu-repo/semantics/altIdentifier/doi/10.1039/C4TB00327F |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614468375412736 |
score |
13.070432 |