Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes
- Autores
- Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society.
Fil: Ferrari, Gabriela Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; Argentina
Fil: Montaña, Maria Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; Argentina - Materia
-
flavonoids
formation constants
Ga (III) complexes
synthesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/93121
Ver los metadatos del registro completo
| id |
CONICETDig_93a53003d03e30ca9fcfd55fedab3732 |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/93121 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) ComplexesFerrari, Gabriela VerónicaPappano, Nora BeatrizMontaña, Maria PaulinaGarcia, Norman AndinoDebattista, Nora Beatrizflavonoidsformation constantsGa (III) complexessynthesishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society.Fil: Ferrari, Gabriela Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; ArgentinaFil: Montaña, Maria Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; ArgentinaAmerican Chemical Society2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93121Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz; Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes; American Chemical Society; Journal of Chemical and Engineering Data; 55; 9; 9-2010; 3080-30830021-9568CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/je901091finfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/je901091finfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:57:48Zoai:ri.conicet.gov.ar:11336/93121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:57:48.735CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| title |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| spellingShingle |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes Ferrari, Gabriela Verónica flavonoids formation constants Ga (III) complexes synthesis |
| title_short |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| title_full |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| title_fullStr |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| title_full_unstemmed |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| title_sort |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
| dc.creator.none.fl_str_mv |
Ferrari, Gabriela Verónica Pappano, Nora Beatriz Montaña, Maria Paulina Garcia, Norman Andino Debattista, Nora Beatriz |
| author |
Ferrari, Gabriela Verónica |
| author_facet |
Ferrari, Gabriela Verónica Pappano, Nora Beatriz Montaña, Maria Paulina Garcia, Norman Andino Debattista, Nora Beatriz |
| author_role |
author |
| author2 |
Pappano, Nora Beatriz Montaña, Maria Paulina Garcia, Norman Andino Debattista, Nora Beatriz |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
flavonoids formation constants Ga (III) complexes synthesis |
| topic |
flavonoids formation constants Ga (III) complexes synthesis |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society. Fil: Ferrari, Gabriela Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; Argentina Fil: Montaña, Maria Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; Argentina |
| description |
Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010-09 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/93121 Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz; Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes; American Chemical Society; Journal of Chemical and Engineering Data; 55; 9; 9-2010; 3080-3083 0021-9568 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/93121 |
| identifier_str_mv |
Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz; Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes; American Chemical Society; Journal of Chemical and Engineering Data; 55; 9; 9-2010; 3080-3083 0021-9568 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1021/je901091f info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/je901091f |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Chemical Society |
| publisher.none.fl_str_mv |
American Chemical Society |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1846083117326008320 |
| score |
13.22299 |