Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes
- Autores
- Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society.
Fil: Ferrari, Gabriela Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; Argentina
Fil: Montaña, Maria Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; Argentina - Materia
-
flavonoids
formation constants
Ga (III) complexes
synthesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/93121
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Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) ComplexesFerrari, Gabriela VerónicaPappano, Nora BeatrizMontaña, Maria PaulinaGarcia, Norman AndinoDebattista, Nora Beatrizflavonoidsformation constantsGa (III) complexessynthesishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society.Fil: Ferrari, Gabriela Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; ArgentinaFil: Montaña, Maria Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; ArgentinaAmerican Chemical Society2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93121Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz; Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes; American Chemical Society; Journal of Chemical and Engineering Data; 55; 9; 9-2010; 3080-30830021-9568CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/je901091finfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/je901091finfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:44Zoai:ri.conicet.gov.ar:11336/93121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:44.312CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
title |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
spellingShingle |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes Ferrari, Gabriela Verónica flavonoids formation constants Ga (III) complexes synthesis |
title_short |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
title_full |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
title_fullStr |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
title_full_unstemmed |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
title_sort |
Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes |
dc.creator.none.fl_str_mv |
Ferrari, Gabriela Verónica Pappano, Nora Beatriz Montaña, Maria Paulina Garcia, Norman Andino Debattista, Nora Beatriz |
author |
Ferrari, Gabriela Verónica |
author_facet |
Ferrari, Gabriela Verónica Pappano, Nora Beatriz Montaña, Maria Paulina Garcia, Norman Andino Debattista, Nora Beatriz |
author_role |
author |
author2 |
Pappano, Nora Beatriz Montaña, Maria Paulina Garcia, Norman Andino Debattista, Nora Beatriz |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
flavonoids formation constants Ga (III) complexes synthesis |
topic |
flavonoids formation constants Ga (III) complexes synthesis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society. Fil: Ferrari, Gabriela Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; Argentina Fil: Montaña, Maria Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; Argentina |
description |
Flavonoids are a wide variety of polyphenolic compounds. They have many biological properties. They also exhibit a metallic ion complexation capacity, which is important since it has been found that biological properties these ligands present can be enhanced when complexation occurs. In this work four flavonoid-Ga(III) complexes were studied: 2′,4′,3- trihydroxychalcone-Ga(III), 2′,3-dihydroxychalcone-Ga(III), 3,7,3′-trihydroxyflavone-Ga(III), and 3,3′-dihydroxyflavone-Ga(III). All ligands were synthesized by our working group, contributing a novel, cheaper, and more simple way to obtain 3,3′-dihydroxyflavone. The stoichiometry of the complexes was determined using the Yoe-Jones method. Both chalcone-Ga(III) complexes presented 1:1 L:M stoichiometry; meanwhile flavone-Ga(III) complexes presented 2:1 L:M stoichiometry. The pK values were determined by means of a spectrophotometric method. Values obtained were: 2′,4′,3-trihydroxychalcone-Ga(III), pK = 4.35 ± 0.38; 2′,3-dihydroxychalcone-Ga(III), pK = 3.40 ± 0.17; 3,7,3′-trihydroxyflavone-Ga(III), pK = 7.74 ± 0.19; and 3,3′-dihydroxyflavone-Ga(III), pK = 8.46 ± 0.27. © 2010 American Chemical Society. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/93121 Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz; Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes; American Chemical Society; Journal of Chemical and Engineering Data; 55; 9; 9-2010; 3080-3083 0021-9568 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/93121 |
identifier_str_mv |
Ferrari, Gabriela Verónica; Pappano, Nora Beatriz; Montaña, Maria Paulina; Garcia, Norman Andino; Debattista, Nora Beatriz; Novel synthesis of 3,3′-dihydroxyflavone and apparent formation constants of flavonoid-Ga(III) Complexes; American Chemical Society; Journal of Chemical and Engineering Data; 55; 9; 9-2010; 3080-3083 0021-9568 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1021/je901091f info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/je901091f |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613814565208064 |
score |
13.070432 |