An international review of the characteristics of viral nucleic acid-amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT

• Autores: Faddy, Helen M.; Osiowy, Carla; Custer, Brian; Busch, Michael; Stramer, Susan L.; Dean, Melinda M.; Acutt, Jessika; Viennet, Elvina; van de Laar, Thijs; Tsoi, Wai-Chiu; Styles, Claire; Kiely, Phil; Margaritis, Angelo; Kwon, So-Yong; Qiu, Yan; Deng, Xuelian; Lewin, Antoine; Jørgensen, Signe Winther; Erikstrup, Christian; Juhl, David; Sauleda, Silvia; Camacho Rodriguez, Bernardo Armando; Soto Coral, Lisbeth Jennifer Catherine; Gaviria García, Paula Andrea; Oota, Sineenart; O'Brien, Sheila F.; Wendel, Silvano; Castro, Emma; Navarro Pérez, Laura; Harvala, Heli; Davison, Katy; Reynolds, Claire; Jarvis, Lisa; Grabarczyk, Piotr; Kopacz, Aneta; Letowska, Magdalena; O'Flaherty, Niamh; Young, Fiona; Williams, Padraig; Burke, Lisa; Chua, Sze Sze; Muylaert, An; Page, Isabel; Jones, Ann; Niederhauser, Christoph; Vermeulen, Marion; Laperche, Syria; Gallian, Pierre; Satake, Masahiro; Addas Carvalho, Marcelo; Blanco, Sebastian; Gallego, Sandra Veronica; Seltsam, Axel; Weber Schehl, Marijke; Al-Riyami, Arwa Z.; Al Maamari, Khuloud; Alawi, Fatma Ba; Pandey, Hem Chandra; França, Rochele Azevedo; Charlewood, Richard
• Año de publicación: 2024
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Transfusion safety; Blood banks; NAT; Blood donors
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background and Objectives: Nucleic acid-amplification testing (NAT) is used forscreening blood donations/donors for blood-borne viruses. We reviewed global viralNAT characteristics and NAT-yield confirmatory testing used by blood operators.Materials and Methods: NAT characteristics and NAT-yield confirmatory testingused during 2019 was surveyed internationally by the International Society of Blood Transfusion Working Party Transfusion-Transmitted Infectious Diseases. Reportedcharacteristics are presented herein.Results: NAT was mainly performed under government mandate. Human immunodeficiency virus (HIV), hepatitis C virus (HCV) and hepatitis B virus (HBV) NAT was performed on all donors and donation types, while selective testing was reported forWest Nile virus, hepatitis E virus (HEV), and Zika virus. Individual donation NAT wasused for HIV, HCV and HBV by 50% of responders, while HEV was screened inmini-pools by 83% of responders performing HEV NAT. Confirmatory testing forNAT-yield samples was generally performed by NAT on a sample from the samedonation or by NAT and serology on samples from the same donation and a followup sample.Conclusion: In the last decade, there has been a trend towards use of smaller poolsizes or individual donation NAT. We captured characteristics of NAT internationallyin 2019 and provide insights into confirmatory testing approaches used for NATyields, potentially benefitting blood operators seeking to implement NAT.
Fil: Faddy, Helen M.. University of the Sunshine Coast. School of Health; Australia. Australian Red Cross Lifeblood; Australia
Fil: Osiowy, Carla. Public Health Agency. National Microbiology Laboratory; Canadá
Fil: Custer, Brian. Vitalant Research Institute; Estados Unidos. University of California; Estados Unidos
Fil: Busch, Michael. Vitalant Research Institute; Estados Unidos
Fil: Stramer, Susan L.. Infectious Disease Consultant; Estados Unidos
Fil: Dean, Melinda M.. University of the Sunshine Coast. School of Health; Australia. Australian Red Cross Lifeblood; Australia
Fil: Acutt, Jessika. University of the Sunshine Coast. School of Health; Australia
Fil: Viennet, Elvina. Australian Red Cross Lifeblood; Australia
Fil: van de Laar, Thijs. Sanquin Research; Países Bajos
Fil: Tsoi, Wai-Chiu. Hong Kong Red Cross Blood Transfusion Service; Hong Kong
Fil: Styles, Claire. Australian Red Cross Lifeblood; Australia
Fil: Kiely, Phil. Australian Red Cross Lifeblood; Australia
Fil: Margaritis, Angelo. Australian Red Cross Lifeblood; Australia
Fil: Kwon, So-Yong. Korean Red Cross Blood Services; Corea del Sur
Fil: Qiu, Yan. Beijing Red Cross Blood Centre; China
Fil: Deng, Xuelian. Dalian Blood Centre; China
Fil: Lewin, Antoine. Medical Affairs And Innovation; Canadá
Fil: Jørgensen, Signe Winther. University Aarhus; Dinamarca
Fil: Erikstrup, Christian. University Aarhus; Dinamarca
Fil: Juhl, David. University Hospital Of Schleswig-holstein; Alemania
Fil: Sauleda, Silvia. Banc de Sang I Teixits de Catalunya; España
Fil: Camacho Rodriguez, Bernardo Armando. Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud; Colombia
Fil: Soto Coral, Lisbeth Jennifer Catherine. Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud; Colombia
Fil: Gaviria García, Paula Andrea. Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud; Colombia
Fil: Oota, Sineenart. Thai Red Cross Society; Tailandia
Fil: O'Brien, Sheila F.. Canadian Blood Service; Canadá
Fil: Wendel, Silvano. Hospital Sírio-Libanês Blood Bank; Brasil
Fil: Castro, Emma. Centro de Transfusión de la Comunidad Valenciana; España
Fil: Navarro Pérez, Laura. Centro de Transfusión de la Comunidad Valenciana; España
Fil: Harvala, Heli. NHS Blood and Transplant; Reino Unido
Fil: Davison, Katy. NHSBT/UKHSA Epidemiology Unit; Reino Unido
Fil: Reynolds, Claire. NHSBT/UKHSA Epidemiology Unit; Reino Unido
Fil: Jarvis, Lisa. Scottish National Blood Transfusion Service; Reino Unido
Fil: Grabarczyk, Piotr. Institute of Hematology and Transfusion Medicine; Polonia
Fil: Kopacz, Aneta. Institute of Hematology and Transfusion Medicine; Polonia
Fil: Letowska, Magdalena. Institute of Hematology and Transfusion Medicine; Polonia
Fil: O'Flaherty, Niamh. Irish Blood Transfusion Service; Irlanda
Fil: Young, Fiona. Irish Blood Transfusion Service; Irlanda
Fil: Williams, Padraig. Irish Blood Transfusion Service; Irlanda
Fil: Burke, Lisa. Irish Blood Transfusion Service; Irlanda
Fil: Chua, Sze Sze. Health Sciences Authority; Singapur
Fil: Muylaert, An. Red Cross Flanders; Bélgica
Fil: Page, Isabel. Centro de Hemoterapia y Hemodonacion de Castilla y Leon; España
Fil: Jones, Ann. Welsh Blood Service; Reino Unido
Fil: Niederhauser, Christoph. Interregional Blood Transfusion SRC; Suiza
Fil: Vermeulen, Marion. The South African National Blood Service; Sudáfrica
Fil: Laperche, Syria. Etablissement Français du Sang; Francia
Fil: Gallian, Pierre. Etablissement Français du Sang; Francia
Fil: Satake, Masahiro. Japanese Red Cross Blood Service; Japón
Fil: Addas Carvalho, Marcelo. Blood Center of Universidade Estadual de Campinas; Brasil
Fil: Blanco, Sebastian. Fundacion Banco Central de Sangre; Argentina
Fil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Seltsam, Axel. Bavarian Red Cross Blood Donation Service; Alemania
Fil: Weber Schehl, Marijke. Bavarian Red Cross Blood Donation Service; Alemania
Fil: Al-Riyami, Arwa Z.. Sultan Qaboos University Hospital; Omán
Fil: Al Maamari, Khuloud. Sultan Qaboos University Hospital; Omán
Fil: Alawi, Fatma Ba. Sultan Qaboos University Hospital; Omán
Fil: Pandey, Hem Chandra. All India Institute of Medical Sciences; India
Fil: França, Rochele Azevedo. Regional Blood Center of Ribeirão Preto; Brasil
Fil: Charlewood, Richard. New Zealand Blood Service; Nueva Zelanda