International review of blood donation nucleic acid amplification testing

• Autores: Faddy, Helen M.; Osiowy, Carla; Custer, Brian; Busch, Michael; Stramer, Susan L.; Adesina, Opeyemi; van de Laar, Thijs; Tsoi, Wai-Chiu; Styles, Claire; Kiely, Phil; Margaritis, Angelo; Kwon, So-Yong; Qiu, Yan; Deng, Xuelian; Lewin, Antoine; Jørgensen, Signe Winther; Erikstrup, Christian; Juhl, David; Sauleda, Silvia; Camacho Rodriguez, Bernardo Armando; Soto Coral, Lisbeth Jennifer Catherine; Gaviria García, Paula Andrea; Oota, Sineenart; O'Brien, Sheila F.; Wendel, Silvano; Castro, Emma; Navarro Pérez, Laura; Harvala, Heli; Davison, Katy; Reynolds, Claire; Jarvis, Lisa; Grabarczyk, Piotr; Kopacz, Aneta; Łętowska, Magdalena; O'Flaherty, Niamh; Young, Fiona; Williams, Padraig; Burke, Lisa; Chua, Sze Sze; Muylaert, An; Page, Isabel; Jones, Ann; Niederhauser, Christoph; Vermeulen, Marion; Laperche, Syria; Gallian, Pierre; Sawadogo, Salam; Satake, Masahiro; Gharehbaghian, Ahmad; Addas-Carvalho, Marcelo; Blanco, Sebastian; Gallego, Sandra Veronica; Seltsam, Axel; Weber Schehl, Marijke; Al-Riyami, Arwa Z.; Al Maamari, Khuloud; Alawi, Fatma Ba; Pandey, Hem Chandra; Mbanya, Dora; Azevedo França, Rochele; Charlewood, Richard
• Año de publicación: 2024
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: NAT; Blood; Virus; ITT
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background and Objectives Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion-transmitted infections. This project reviewed NAT for screening blood donations globally. Materials and Methods A survey on NAT usage, developed by the International Society of Blood Transfusion Working Party on Transfusion-transmitted Infectious Diseases (ISBT WP-TTID), was distributed through ISBT WP-TTID members. Data were analysed using descriptive statistics. Results Forty-three responses were received from 32 countries. Increased adoption of blood donation viral screening by NAT was observed over the past decade. NAT-positive donations were detected for all viruses tested in 2019 (proportion of donations positive by NAT were 0.0099% for human immunodeficiency virus [HIV], 0.0063% for hepatitis C virus [HCV], 0.0247% for hepatitis B virus [HBV], 0.0323% for hepatitis E virus [HEV], 0.0014% for West Nile virus [WNV] and 0.00005% for Zika virus [ZIKV]). Globally, over 3100 NAT-positive donations were identified as NAT yield or solely by NAT in 2019 and over 22,000 since the introduction of NAT, with HBV accounting for over half. NAT-positivity rate was higher in first-time donors for all viruses tested except WNV. During 2019, a small number of participants performed NAT for parasites (Trypanosoma cruzi, Babesia spp., Plasmodium spp.). Conclusion This survey captures current use of blood donation NAT globally. There has been increased NAT usage over the last decade. It is clear that NAT contributes to improving blood transfusion safety globally; however, there is a need to overcome economic barriers for regions/countries not performing NAT.
Fil: Faddy, Helen M.. School Of Health, University Of The Sunshine Coast,; Australia
Fil: Osiowy, Carla. Public Health Agency of Canada; Canadá
Fil: Custer, Brian. University of California San Francisco; Estados Unidos. Vitalant Research Institute; Estados Unidos
Fil: Busch, Michael. Vitalant Research Institute; Estados Unidos
Fil: Stramer, Susan L.. American Red Cross; Estados Unidos
Fil: Adesina, Opeyemi. Babcock University; Nigeria
Fil: van de Laar, Thijs. Sanquin Research; Países Bajos
Fil: Tsoi, Wai-Chiu. Hong Kong Red Cross Blood Transfusion Service; Hong Kong
Fil: Styles, Claire. Australian Red Cross Lifeblood; Australia
Fil: Kiely, Phil. Australian Red Cross Lifeblood; Australia
Fil: Margaritis, Angelo. Australian Red Cross Lifeblood; Australia
Fil: Kwon, So-Yong. Korean Red Cross Blood Services; Corea del Sur
Fil: Qiu, Yan. Beijing Red Cross Blood Centre; China
Fil: Deng, Xuelian. Dalian Blood Centre; China
Fil: Lewin, Antoine. Medical Affairs and Innovation, Héma-Québec; Canadá
Fil: Jørgensen, Signe Winther. University Aarhus; Dinamarca
Fil: Erikstrup, Christian. University Aarhus; Dinamarca
Fil: Juhl, David. University Hospital of Schleswig-Holstein. Institute of Transfusion Medicine; Alemania
Fil: Sauleda, Silvia. Banc de Sang i Teixits de Catalunya; España
Fil: Camacho Rodriguez, Bernardo Armando. Instituto Distrital de Ciencia Biotecnología e Innovación en Salud; Colombia
Fil: Soto Coral, Lisbeth Jennifer Catherine. Instituto Distrital de Ciencia Biotecnología e Innovación en Salud; Colombia
Fil: Gaviria García, Paula Andrea. Instituto Distrital de Ciencia Biotecnología e Innovación en Salud; Colombia
Fil: Oota, Sineenart. Thai Red Cross Society; Tailandia
Fil: O'Brien, Sheila F.. Canadian Blood Services; Canadá
Fil: Wendel, Silvano. Hospital Sírio-Libanês Blood Bank; Brasil
Fil: Castro, Emma. Centro de Transfusión de la Comunidad Valenciana; España
Fil: Navarro Pérez, Laura. Centro de Transfusión de la Comunidad Valenciana; España
Fil: Harvala, Heli. NHS Blood and Transplant; Reino Unido
Fil: Davison, Katy. NHSBT/UKHSA Epidemiology Unit; Reino Unido
Fil: Reynolds, Claire. NHSBT/UKHSA Epidemiology Unit; Reino Unido
Fil: Jarvis, Lisa. Scottish National Blood Transfusion Service; Reino Unido
Fil: Grabarczyk, Piotr. Institute of Hematology and Transfusion Medicine; Polonia
Fil: Kopacz, Aneta. Institute of Hematology and Transfusion Medicine; Polonia
Fil: Łętowska, Magdalena. Institute of Hematology and Transfusion Medicine; Polonia
Fil: O'Flaherty, Niamh. Irish Blood Transfusion Service; Reino Unido
Fil: Young, Fiona. Irish Blood Transfusion Service; Reino Unido
Fil: Williams, Padraig. Irish Blood Transfusion Service; Reino Unido
Fil: Burke, Lisa. Irish Blood Transfusion Service; Reino Unido
Fil: Chua, Sze Sze. Health Sciences Authority; Singapur
Fil: Muylaert, An. Red Cross Flanders; Bélgica
Fil: Page, Isabel. Centro de Hemoterapia y Hemodonacion de Castilla y Leon; España
Fil: Jones, Ann. Welsh Blood Service; Reino Unido
Fil: Niederhauser, Christoph. Interregional Blood Transfusion SRC; Suiza
Fil: Vermeulen, Marion. The South African National Blood Service; Sudáfrica
Fil: Laperche, Syria. Etablissement Français du Sang; Francia
Fil: Gallian, Pierre. Etablissement Français du Sang; Francia
Fil: Sawadogo, Salam. National Blood Transfusion Center of Burkina Faso; Burkina Faso
Fil: Satake, Masahiro. Japanese Red Cross Blood Service; Japón
Fil: Gharehbaghian, Ahmad. Shahid Beheshti University of Medical Sciences; Irán
Fil: Addas-Carvalho, Marcelo. Universidade Estadual de Campinas; Brasil
Fil: Blanco, Sebastian. Fundación Banco Central de Sangre; Argentina
Fil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Seltsam, Axel. Bavarian Red Cross Blood Donation Service; Alemania
Fil: Weber Schehl, Marijke. Bavarian Red Cross Blood Donation Service; Alemania
Fil: Al-Riyami, Arwa Z.. Sultan Qaboos University Hospital; Omán
Fil: Al Maamari, Khuloud. Sultan Qaboos University Hospital; Omán
Fil: Alawi, Fatma Ba. Sultan Qaboos University Hospital; Omán
Fil: Pandey, Hem Chandra. All India Institute of Medical Sciences; India
Fil: Mbanya, Dora. National Blood Transfusion Service; Camerún
Fil: Azevedo França, Rochele. Regional Blood Center of Ribeirão Preto; Brasil
Fil: Charlewood, Richard. New Zealand Blood Service; Nueva Zelanda