A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix

Autores
Martínez, María Victoria; Rivarola, Claudia Rosana; Miras, María Cristina; Barbero, César Alberto
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A combinatorial library of hydrogels is produced by radical polymerization and tested for retention of iron (II) complexes, using a simple colorimetric high throughput screening (HTS). Six acrylamide monomers are used to produce a library of 21 cross-linked hydrogel matrixes. The swelling of all hydrogels is determined and related with the structure of each monomer unit present. The HTS shows that some materials are able to retain the tris(phenanthroline)iron(II) (Fe(Phen)32+) complex. The partition coefficient of Fe(H2O)62+ and Fe(Phen)32+ in all hydrogels is determined by UV–vis spectrophotometry and related with the presence of anionic (e.g. −SO3−), hydrophobic (e.g. isopropyl) and hydrophilic (e.g. −NH2 of acrylamide) groups. Hydrogels with sulfonic (−SO3−) groups show large values of partition coefficients of Fe2+ into the hydrogel (>500). Based on the data and HTS, poly(acrylamide-co-50%(2-acrylamido-2-methylpropansulfonic acid)) (PAAm-co-50%AMPS) is selected to build a colorimetric sensor. Since the phenanthroline could be released from the hydrogel, bathophenanthroline (BPhen) which is not released is used as ligand. The hydrogel is loaded with BPhen and exposed to Fe2+ in water. The visual detection of color gives a detection limit of 0.1 ppm. Little interference of different common ions is found. A special set-up is made which allows spectrophotometric measurement of the complex inside the gel. The detection limit is found to be of ca. 0.01 ppm by spectrophotometry. Using the sensor, the iron content in milk is measured directly demonstrating the use of the sensor to measure free iron in opaque liquids where solution spectrophotometry is not effective without complex sample pretreatments. The non-covalent retention of ligands and complexes inside polymeric hydrogels seems to be a suitable method for building specific ion sensors.
Fil: Martínez, María Victoria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Rivarola, Claudia Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Miras, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Barbero, César Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Materia
COLORIMETRIC
COMBINATORIAL CHEMISTRY
HYDROGEL
IRON
LIGANDS
SENSOR
WATER QUALITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99084
Acceder
id CONICETDig_92fcad34cb2ef614c25558269e486060
oai_identifier_str oai:ri.conicet.gov.ar:11336/99084
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrixMartínez, María VictoriaRivarola, Claudia RosanaMiras, María CristinaBarbero, César AlbertoCOLORIMETRICCOMBINATORIAL CHEMISTRYHYDROGELIRONLIGANDSSENSORWATER QUALITYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A combinatorial library of hydrogels is produced by radical polymerization and tested for retention of iron (II) complexes, using a simple colorimetric high throughput screening (HTS). Six acrylamide monomers are used to produce a library of 21 cross-linked hydrogel matrixes. The swelling of all hydrogels is determined and related with the structure of each monomer unit present. The HTS shows that some materials are able to retain the tris(phenanthroline)iron(II) (Fe(Phen)32+) complex. The partition coefficient of Fe(H2O)62+ and Fe(Phen)32+ in all hydrogels is determined by UV–vis spectrophotometry and related with the presence of anionic (e.g. −SO3−), hydrophobic (e.g. isopropyl) and hydrophilic (e.g. −NH2 of acrylamide) groups. Hydrogels with sulfonic (−SO3−) groups show large values of partition coefficients of Fe2+ into the hydrogel (>500). Based on the data and HTS, poly(acrylamide-co-50%(2-acrylamido-2-methylpropansulfonic acid)) (PAAm-co-50%AMPS) is selected to build a colorimetric sensor. Since the phenanthroline could be released from the hydrogel, bathophenanthroline (BPhen) which is not released is used as ligand. The hydrogel is loaded with BPhen and exposed to Fe2+ in water. The visual detection of color gives a detection limit of 0.1 ppm. Little interference of different common ions is found. A special set-up is made which allows spectrophotometric measurement of the complex inside the gel. The detection limit is found to be of ca. 0.01 ppm by spectrophotometry. Using the sensor, the iron content in milk is measured directly demonstrating the use of the sensor to measure free iron in opaque liquids where solution spectrophotometry is not effective without complex sample pretreatments. The non-covalent retention of ligands and complexes inside polymeric hydrogels seems to be a suitable method for building specific ion sensors.Fil: Martínez, María Victoria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Rivarola, Claudia Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Miras, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Barbero, César Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaElsevier Science Sa2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99084Martínez, María Victoria; Rivarola, Claudia Rosana; Miras, María Cristina; Barbero, César Alberto; A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix; Elsevier Science Sa; Sensors and Actuators B: Chemical; 241; 3-2017; 19-320925-4005CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.snb.2016.10.013info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0925400516316392info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:47Zoai:ri.conicet.gov.ar:11336/99084instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:47.511CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
title A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
spellingShingle A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
Martínez, María Victoria
COLORIMETRIC
COMBINATORIAL CHEMISTRY
HYDROGEL
IRON
LIGANDS
SENSOR
WATER QUALITY
title_short A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
title_full A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
title_fullStr A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
title_full_unstemmed A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
title_sort A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix
dc.creator.none.fl_str_mv Martínez, María Victoria
Rivarola, Claudia Rosana
Miras, María Cristina
Barbero, César Alberto
author Martínez, María Victoria
author_facet Martínez, María Victoria
Rivarola, Claudia Rosana
Miras, María Cristina
Barbero, César Alberto
author_role author
author2 Rivarola, Claudia Rosana
Miras, María Cristina
Barbero, César Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv COLORIMETRIC
COMBINATORIAL CHEMISTRY
HYDROGEL
IRON
LIGANDS
SENSOR
WATER QUALITY
topic COLORIMETRIC
COMBINATORIAL CHEMISTRY
HYDROGEL
IRON
LIGANDS
SENSOR
WATER QUALITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A combinatorial library of hydrogels is produced by radical polymerization and tested for retention of iron (II) complexes, using a simple colorimetric high throughput screening (HTS). Six acrylamide monomers are used to produce a library of 21 cross-linked hydrogel matrixes. The swelling of all hydrogels is determined and related with the structure of each monomer unit present. The HTS shows that some materials are able to retain the tris(phenanthroline)iron(II) (Fe(Phen)32+) complex. The partition coefficient of Fe(H2O)62+ and Fe(Phen)32+ in all hydrogels is determined by UV–vis spectrophotometry and related with the presence of anionic (e.g. −SO3−), hydrophobic (e.g. isopropyl) and hydrophilic (e.g. −NH2 of acrylamide) groups. Hydrogels with sulfonic (−SO3−) groups show large values of partition coefficients of Fe2+ into the hydrogel (>500). Based on the data and HTS, poly(acrylamide-co-50%(2-acrylamido-2-methylpropansulfonic acid)) (PAAm-co-50%AMPS) is selected to build a colorimetric sensor. Since the phenanthroline could be released from the hydrogel, bathophenanthroline (BPhen) which is not released is used as ligand. The hydrogel is loaded with BPhen and exposed to Fe2+ in water. The visual detection of color gives a detection limit of 0.1 ppm. Little interference of different common ions is found. A special set-up is made which allows spectrophotometric measurement of the complex inside the gel. The detection limit is found to be of ca. 0.01 ppm by spectrophotometry. Using the sensor, the iron content in milk is measured directly demonstrating the use of the sensor to measure free iron in opaque liquids where solution spectrophotometry is not effective without complex sample pretreatments. The non-covalent retention of ligands and complexes inside polymeric hydrogels seems to be a suitable method for building specific ion sensors.
Fil: Martínez, María Victoria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Rivarola, Claudia Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Miras, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Barbero, César Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
description A combinatorial library of hydrogels is produced by radical polymerization and tested for retention of iron (II) complexes, using a simple colorimetric high throughput screening (HTS). Six acrylamide monomers are used to produce a library of 21 cross-linked hydrogel matrixes. The swelling of all hydrogels is determined and related with the structure of each monomer unit present. The HTS shows that some materials are able to retain the tris(phenanthroline)iron(II) (Fe(Phen)32+) complex. The partition coefficient of Fe(H2O)62+ and Fe(Phen)32+ in all hydrogels is determined by UV–vis spectrophotometry and related with the presence of anionic (e.g. −SO3−), hydrophobic (e.g. isopropyl) and hydrophilic (e.g. −NH2 of acrylamide) groups. Hydrogels with sulfonic (−SO3−) groups show large values of partition coefficients of Fe2+ into the hydrogel (>500). Based on the data and HTS, poly(acrylamide-co-50%(2-acrylamido-2-methylpropansulfonic acid)) (PAAm-co-50%AMPS) is selected to build a colorimetric sensor. Since the phenanthroline could be released from the hydrogel, bathophenanthroline (BPhen) which is not released is used as ligand. The hydrogel is loaded with BPhen and exposed to Fe2+ in water. The visual detection of color gives a detection limit of 0.1 ppm. Little interference of different common ions is found. A special set-up is made which allows spectrophotometric measurement of the complex inside the gel. The detection limit is found to be of ca. 0.01 ppm by spectrophotometry. Using the sensor, the iron content in milk is measured directly demonstrating the use of the sensor to measure free iron in opaque liquids where solution spectrophotometry is not effective without complex sample pretreatments. The non-covalent retention of ligands and complexes inside polymeric hydrogels seems to be a suitable method for building specific ion sensors.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99084
Martínez, María Victoria; Rivarola, Claudia Rosana; Miras, María Cristina; Barbero, César Alberto; A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix; Elsevier Science Sa; Sensors and Actuators B: Chemical; 241; 3-2017; 19-32
0925-4005
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99084
identifier_str_mv Martínez, María Victoria; Rivarola, Claudia Rosana; Miras, María Cristina; Barbero, César Alberto; A colorimetric iron sensor based on the partition of phenanthroline complexes into polymeric hydrogels: Combinatorial synthesis and high throughput screening of the hydrogel matrix; Elsevier Science Sa; Sensors and Actuators B: Chemical; 241; 3-2017; 19-32
0925-4005
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.snb.2016.10.013
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0925400516316392
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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