The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1

Autores
Paladino, Natalia; Flores, Ana Claudia; Fainboim, Hugo; Schroder, Teresa; Cuarterolo, Miriam; Lezama, Carol; Gonzáles Ballerga, Esteban; Levi, Diana; Tanno, Hugo; Costanzo, Gabriel Gustavo; Arruvito, Maria Lourdes; Fainboim, Leonardo
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (low producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC+-25GG- haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH.
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Flores, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Schroder, Teresa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Cuarterolo, Miriam. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina
Fil: Lezama, Carol. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Gonzáles Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Levi, Diana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Tanno, Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Costanzo, Gabriel Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
Hla Associations
Il-10
Interleukin 10
Paediatric And Adult Patients
Single Nucleotide Polymorphisms
Snps
Tgf-Β1
Transforming Growth Factor-Β1
Type I Autoimmune Hepatitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67925
Acceder
id CONICETDig_92eb9e15f1c169cc5f6943af60215b6c
oai_identifier_str oai:ri.conicet.gov.ar:11336/67925
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1Paladino, NataliaFlores, Ana ClaudiaFainboim, HugoSchroder, TeresaCuarterolo, MiriamLezama, CarolGonzáles Ballerga, EstebanLevi, DianaTanno, HugoCostanzo, Gabriel GustavoArruvito, Maria LourdesFainboim, LeonardoHla AssociationsIl-10Interleukin 10Paediatric And Adult PatientsSingle Nucleotide PolymorphismsSnpsTgf-Β1Transforming Growth Factor-Β1Type I Autoimmune Hepatitishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (low producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC+-25GG- haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH.Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Flores, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Schroder, Teresa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Cuarterolo, Miriam. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; ArgentinaFil: Lezama, Carol. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Gonzáles Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Levi, Diana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Tanno, Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Costanzo, Gabriel Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaAcademic Press Inc Elsevier Science2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67925Paladino, Natalia; Flores, Ana Claudia; Fainboim, Hugo; Schroder, Teresa; Cuarterolo, Miriam; et al.; The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1; Academic Press Inc Elsevier Science; Clinical Immunology; 134; 3; 3-2010; 305-3121521-6616CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.clim.2009.11.004info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1521661609008687info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:15:28Zoai:ri.conicet.gov.ar:11336/67925instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:15:29.17CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
title The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
spellingShingle The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
Paladino, Natalia
Hla Associations
Il-10
Interleukin 10
Paediatric And Adult Patients
Single Nucleotide Polymorphisms
Snps
Tgf-Β1
Transforming Growth Factor-Β1
Type I Autoimmune Hepatitis
title_short The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
title_full The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
title_fullStr The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
title_full_unstemmed The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
title_sort The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
dc.creator.none.fl_str_mv Paladino, Natalia
Flores, Ana Claudia
Fainboim, Hugo
Schroder, Teresa
Cuarterolo, Miriam
Lezama, Carol
Gonzáles Ballerga, Esteban
Levi, Diana
Tanno, Hugo
Costanzo, Gabriel Gustavo
Arruvito, Maria Lourdes
Fainboim, Leonardo
author Paladino, Natalia
author_facet Paladino, Natalia
Flores, Ana Claudia
Fainboim, Hugo
Schroder, Teresa
Cuarterolo, Miriam
Lezama, Carol
Gonzáles Ballerga, Esteban
Levi, Diana
Tanno, Hugo
Costanzo, Gabriel Gustavo
Arruvito, Maria Lourdes
Fainboim, Leonardo
author_role author
author2 Flores, Ana Claudia
Fainboim, Hugo
Schroder, Teresa
Cuarterolo, Miriam
Lezama, Carol
Gonzáles Ballerga, Esteban
Levi, Diana
Tanno, Hugo
Costanzo, Gabriel Gustavo
Arruvito, Maria Lourdes
Fainboim, Leonardo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hla Associations
Il-10
Interleukin 10
Paediatric And Adult Patients
Single Nucleotide Polymorphisms
Snps
Tgf-Β1
Transforming Growth Factor-Β1
Type I Autoimmune Hepatitis
topic Hla Associations
Il-10
Interleukin 10
Paediatric And Adult Patients
Single Nucleotide Polymorphisms
Snps
Tgf-Β1
Transforming Growth Factor-Β1
Type I Autoimmune Hepatitis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (low producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC+-25GG- haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH.
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Flores, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Schroder, Teresa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Cuarterolo, Miriam. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina
Fil: Lezama, Carol. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Gonzáles Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Levi, Diana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Tanno, Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Costanzo, Gabriel Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (low producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC+-25GG- haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67925
Paladino, Natalia; Flores, Ana Claudia; Fainboim, Hugo; Schroder, Teresa; Cuarterolo, Miriam; et al.; The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1; Academic Press Inc Elsevier Science; Clinical Immunology; 134; 3; 3-2010; 305-312
1521-6616
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67925
identifier_str_mv Paladino, Natalia; Flores, Ana Claudia; Fainboim, Hugo; Schroder, Teresa; Cuarterolo, Miriam; et al.; The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1; Academic Press Inc Elsevier Science; Clinical Immunology; 134; 3; 3-2010; 305-312
1521-6616
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clim.2009.11.004
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1521661609008687
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980834601074688
score 12.993085

Publicaciones similares