Helicobacter pylori bab genes during chronic colonization

Autores
Matteo, Mario José; Armitano, Rita Ines; Borromeo, Mariela Alejandra; Wonaga, Andres Dario; Olmos, Martín Javier; Catalano, Mariana
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Helicobacter pylori BabA adhesin metastability could yield variants with potential for periodic activation and deactivation of their mediated adherence. babA/B or babB/A chimeras could play an important role in translational regulation. We investigated the frequency of different bab gene profiles in paired isolates from antrum and corpus recovered from patients with chronic gastritis. Isolates from 174 biopsies from 34 patients were included, and bab genes at the three common chromosomal loci were investigated. Inter-micro-niche variation was found in 1/4 patients, counting duplicate copies of babA or babB, babB/A or babA/B chimeras, opposite location of babA and babB or babC and babB, and absence of babB ATG translational codon. Truncated BabA was identified in 2/34 patients without inter-micro-niche variation. Isolates from 12/34 patients harbored babA/B or babB/A chimeras -either in one, several or all micro-niches indicating that chimera formation is a common mechanism to control BabA expression. To note, babA gene was absent in 11/34 patients, and in this population, babA/B chimeras which lack expression predominated over babB/A, able to exhibit Leb binding phenotype.
Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Fil: Armitano, Rita Ines. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borromeo, Mariela Alejandra. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Fil: Wonaga, Andres Dario. Clínica Bazterrica; Argentina
Fil: Olmos, Martín Javier. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Catalano, Mariana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Materia
H. pylori
babA/B chimera
babB/A chimera
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/160819
Acceder
id CONICETDig_92cdfad523702de970e41a23b8123294
oai_identifier_str oai:ri.conicet.gov.ar:11336/160819
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Helicobacter pylori bab genes during chronic colonizationMatteo, Mario JoséArmitano, Rita InesBorromeo, Mariela AlejandraWonaga, Andres DarioOlmos, Martín JavierCatalano, MarianaH. pyloribabA/B chimerababB/A chimerahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Helicobacter pylori BabA adhesin metastability could yield variants with potential for periodic activation and deactivation of their mediated adherence. babA/B or babB/A chimeras could play an important role in translational regulation. We investigated the frequency of different bab gene profiles in paired isolates from antrum and corpus recovered from patients with chronic gastritis. Isolates from 174 biopsies from 34 patients were included, and bab genes at the three common chromosomal loci were investigated. Inter-micro-niche variation was found in 1/4 patients, counting duplicate copies of babA or babB, babB/A or babA/B chimeras, opposite location of babA and babB or babC and babB, and absence of babB ATG translational codon. Truncated BabA was identified in 2/34 patients without inter-micro-niche variation. Isolates from 12/34 patients harbored babA/B or babB/A chimeras -either in one, several or all micro-niches indicating that chimera formation is a common mechanism to control BabA expression. To note, babA gene was absent in 11/34 patients, and in this population, babA/B chimeras which lack expression predominated over babB/A, able to exhibit Leb binding phenotype.Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; ArgentinaFil: Armitano, Rita Ines. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Borromeo, Mariela Alejandra. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; ArgentinaFil: Wonaga, Andres Dario. Clínica Bazterrica; ArgentinaFil: Olmos, Martín Javier. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Catalano, Mariana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentinae-Century Publishing2011-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/160819Matteo, Mario José; Armitano, Rita Ines; Borromeo, Mariela Alejandra; Wonaga, Andres Dario; Olmos, Martín Javier; et al.; Helicobacter pylori bab genes during chronic colonization; e-Century Publishing; International journal of molecular epidemiology and genetics; 2; 3; 30-8-2011; 286-2911948-1756CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://e-century.us/web/journal_toc.php?journal=ijmeg&volume=2&number=3info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166155/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:06Zoai:ri.conicet.gov.ar:11336/160819instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:06.992CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Helicobacter pylori bab genes during chronic colonization
title Helicobacter pylori bab genes during chronic colonization
spellingShingle Helicobacter pylori bab genes during chronic colonization
Matteo, Mario José
H. pylori
babA/B chimera
babB/A chimera
title_short Helicobacter pylori bab genes during chronic colonization
title_full Helicobacter pylori bab genes during chronic colonization
title_fullStr Helicobacter pylori bab genes during chronic colonization
title_full_unstemmed Helicobacter pylori bab genes during chronic colonization
title_sort Helicobacter pylori bab genes during chronic colonization
dc.creator.none.fl_str_mv Matteo, Mario José
Armitano, Rita Ines
Borromeo, Mariela Alejandra
Wonaga, Andres Dario
Olmos, Martín Javier
Catalano, Mariana
author Matteo, Mario José
author_facet Matteo, Mario José
Armitano, Rita Ines
Borromeo, Mariela Alejandra
Wonaga, Andres Dario
Olmos, Martín Javier
Catalano, Mariana
author_role author
author2 Armitano, Rita Ines
Borromeo, Mariela Alejandra
Wonaga, Andres Dario
Olmos, Martín Javier
Catalano, Mariana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv H. pylori
babA/B chimera
babB/A chimera
topic H. pylori
babA/B chimera
babB/A chimera
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Helicobacter pylori BabA adhesin metastability could yield variants with potential for periodic activation and deactivation of their mediated adherence. babA/B or babB/A chimeras could play an important role in translational regulation. We investigated the frequency of different bab gene profiles in paired isolates from antrum and corpus recovered from patients with chronic gastritis. Isolates from 174 biopsies from 34 patients were included, and bab genes at the three common chromosomal loci were investigated. Inter-micro-niche variation was found in 1/4 patients, counting duplicate copies of babA or babB, babB/A or babA/B chimeras, opposite location of babA and babB or babC and babB, and absence of babB ATG translational codon. Truncated BabA was identified in 2/34 patients without inter-micro-niche variation. Isolates from 12/34 patients harbored babA/B or babB/A chimeras -either in one, several or all micro-niches indicating that chimera formation is a common mechanism to control BabA expression. To note, babA gene was absent in 11/34 patients, and in this population, babA/B chimeras which lack expression predominated over babB/A, able to exhibit Leb binding phenotype.
Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Fil: Armitano, Rita Ines. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borromeo, Mariela Alejandra. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Fil: Wonaga, Andres Dario. Clínica Bazterrica; Argentina
Fil: Olmos, Martín Javier. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Catalano, Mariana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
description Helicobacter pylori BabA adhesin metastability could yield variants with potential for periodic activation and deactivation of their mediated adherence. babA/B or babB/A chimeras could play an important role in translational regulation. We investigated the frequency of different bab gene profiles in paired isolates from antrum and corpus recovered from patients with chronic gastritis. Isolates from 174 biopsies from 34 patients were included, and bab genes at the three common chromosomal loci were investigated. Inter-micro-niche variation was found in 1/4 patients, counting duplicate copies of babA or babB, babB/A or babA/B chimeras, opposite location of babA and babB or babC and babB, and absence of babB ATG translational codon. Truncated BabA was identified in 2/34 patients without inter-micro-niche variation. Isolates from 12/34 patients harbored babA/B or babB/A chimeras -either in one, several or all micro-niches indicating that chimera formation is a common mechanism to control BabA expression. To note, babA gene was absent in 11/34 patients, and in this population, babA/B chimeras which lack expression predominated over babB/A, able to exhibit Leb binding phenotype.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160819
Matteo, Mario José; Armitano, Rita Ines; Borromeo, Mariela Alejandra; Wonaga, Andres Dario; Olmos, Martín Javier; et al.; Helicobacter pylori bab genes during chronic colonization; e-Century Publishing; International journal of molecular epidemiology and genetics; 2; 3; 30-8-2011; 286-291
1948-1756
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160819
identifier_str_mv Matteo, Mario José; Armitano, Rita Ines; Borromeo, Mariela Alejandra; Wonaga, Andres Dario; Olmos, Martín Javier; et al.; Helicobacter pylori bab genes during chronic colonization; e-Century Publishing; International journal of molecular epidemiology and genetics; 2; 3; 30-8-2011; 286-291
1948-1756
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://e-century.us/web/journal_toc.php?journal=ijmeg&volume=2&number=3
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166155/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv e-Century Publishing
publisher.none.fl_str_mv e-Century Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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