Influence of Mast Cells on Two Murine Mammary Adenocarcinomas

Autores
Lauria de Cidre, Lilia Susana; Eijan, Ana María; Bertolesi, Gabriel; Isturiz, Martín; Sacerdote de Lustig, Eugenia
Año de publicación
1996
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it.
Fil: Lauria de Cidre, Lilia Susana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Histología Animal; Argentina
Fil: Eijan, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Bertolesi, Gabriel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Histología Animal; Argentina
Fil: Isturiz, Martín. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Unidad documental simple
Materia
MAST CELLS
NEOPLASIAS
TUMOR-BEARING MICE
SACERDOTE INVESTIGADORA
PUBLICACIONES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/122686
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/122686
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of Mast Cells on Two Murine Mammary AdenocarcinomasLauria de Cidre, Lilia SusanaEijan, Ana MaríaBertolesi, GabrielIsturiz, MartínSacerdote de Lustig, EugeniaMAST CELLSNEOPLASIASTUMOR-BEARING MICESACERDOTE INVESTIGADORAPUBLICACIONEShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it.Fil: Lauria de Cidre, Lilia Susana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Histología Animal; ArgentinaFil: Eijan, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Bertolesi, Gabriel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Histología Animal; ArgentinaFil: Isturiz, Martín. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaUnidad documental simpleKarger1996info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfEscalaGrisNo especificaapplication/pdfhttp://hdl.handle.net/11336/122686Lauria de Cidre, Lilia Susana; Eijan, Ana María; Bertolesi, Gabriel; Isturiz, Martín; Sacerdote de Lustig, Eugenia; Influence of Mast Cells on Two Murine Mammary Adenocarcinomas; Karger; Tumor Biology; 17; 6; 1996; 345–3531010-42831423-0380enginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/217999info:eu-repo/semantics/altIdentifier/doi/10.1159/000217999info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:58Zoai:ri.conicet.gov.ar:11336/122686instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:58.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
title Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
spellingShingle Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
Lauria de Cidre, Lilia Susana
MAST CELLS
NEOPLASIAS
TUMOR-BEARING MICE
SACERDOTE INVESTIGADORA
PUBLICACIONES
title_short Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
title_full Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
title_fullStr Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
title_full_unstemmed Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
title_sort Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
dc.creator.none.fl_str_mv Lauria de Cidre, Lilia Susana
Eijan, Ana María
Bertolesi, Gabriel
Isturiz, Martín
Sacerdote de Lustig, Eugenia
author Lauria de Cidre, Lilia Susana
author_facet Lauria de Cidre, Lilia Susana
Eijan, Ana María
Bertolesi, Gabriel
Isturiz, Martín
Sacerdote de Lustig, Eugenia
author_role author
author2 Eijan, Ana María
Bertolesi, Gabriel
Isturiz, Martín
Sacerdote de Lustig, Eugenia
author2_role author
author
author
author
dc.subject.none.fl_str_mv MAST CELLS
NEOPLASIAS
TUMOR-BEARING MICE
SACERDOTE INVESTIGADORA
PUBLICACIONES
topic MAST CELLS
NEOPLASIAS
TUMOR-BEARING MICE
SACERDOTE INVESTIGADORA
PUBLICACIONES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it.
Fil: Lauria de Cidre, Lilia Susana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Histología Animal; Argentina
Fil: Eijan, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Bertolesi, Gabriel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Histología Animal; Argentina
Fil: Isturiz, Martín. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Unidad documental simple
description A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it.
publishDate 1996
dc.date.none.fl_str_mv 1996
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/122686
Lauria de Cidre, Lilia Susana; Eijan, Ana María; Bertolesi, Gabriel; Isturiz, Martín; Sacerdote de Lustig, Eugenia; Influence of Mast Cells on Two Murine Mammary Adenocarcinomas; Karger; Tumor Biology; 17; 6; 1996; 345–353
1010-4283
1423-0380
url http://hdl.handle.net/11336/122686
identifier_str_mv Lauria de Cidre, Lilia Susana; Eijan, Ana María; Bertolesi, Gabriel; Isturiz, Martín; Sacerdote de Lustig, Eugenia; Influence of Mast Cells on Two Murine Mammary Adenocarcinomas; Karger; Tumor Biology; 17; 6; 1996; 345–353
1010-4283
1423-0380
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/217999
info:eu-repo/semantics/altIdentifier/doi/10.1159/000217999
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
EscalaGris
No especifica
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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