Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America

Autores
Maglietti, Felipe Horacio; Tellado, Matías; De Robertis, Mariangela; Michinski, Sebastián Diego; Fernández, Juan; Signori, Emanuela; Marshall, Guillermo Ricardo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in human and veterinary medicine. It induces a local yet robust immune response that is responsible for its high effectiveness. Gene electrotransfer (GET), used in research to produce a systemic immune response against cancer, is another electroporation-based treatment that is very appealing for its effectiveness, low cost, and simplicity. In this review, we present the immune effect of electroporation-based treatments and analyze the results of the vast majority of the published papers related to immune response enhancement by gene electrotransfer in companion animals with spontaneous tumors. In addition, we present a brief history of the initial steps and the state of the art of the electroporation-based treatments in Latin America. They have the potential to become an essential form of immunotherapy in the region. This review gives insight into the subject and helps to choose promising research lines for future work; it also helps to select the adequate treatment parameters for performing a successful application of this technology.
Fil: Maglietti, Felipe Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
Fil: Tellado, Matías. Clínica Vetoncologia; Argentina
Fil: De Robertis, Mariangela. Consiglio Nazionale delle Ricerche; Italia. Università degli Studi di Bari; Italia
Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Fernández, Juan. Clínica Vetoncologia; Argentina
Fil: Signori, Emanuela. Consiglio Nazionale Delle Ricerche. Departimento Di Medicina. Instituto Di Farmacología Traslazionale; Italia
Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Materia
CANCER
COMPANION ANIMALS
ELECTROCHEMOTHERAPY
GENE ELECTROTRANSFER
GENE THERAPY
IMMUNE RESPONSE
TUMOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170764
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/170764
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin AmericaMaglietti, Felipe HoracioTellado, MatíasDe Robertis, MariangelaMichinski, Sebastián DiegoFernández, JuanSignori, EmanuelaMarshall, Guillermo RicardoCANCERCOMPANION ANIMALSELECTROCHEMOTHERAPYGENE ELECTROTRANSFERGENE THERAPYIMMUNE RESPONSETUMORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in human and veterinary medicine. It induces a local yet robust immune response that is responsible for its high effectiveness. Gene electrotransfer (GET), used in research to produce a systemic immune response against cancer, is another electroporation-based treatment that is very appealing for its effectiveness, low cost, and simplicity. In this review, we present the immune effect of electroporation-based treatments and analyze the results of the vast majority of the published papers related to immune response enhancement by gene electrotransfer in companion animals with spontaneous tumors. In addition, we present a brief history of the initial steps and the state of the art of the electroporation-based treatments in Latin America. They have the potential to become an essential form of immunotherapy in the region. This review gives insight into the subject and helps to choose promising research lines for future work; it also helps to select the adequate treatment parameters for performing a successful application of this technology.Fil: Maglietti, Felipe Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; ArgentinaFil: Tellado, Matías. Clínica Vetoncologia; ArgentinaFil: De Robertis, Mariangela. Consiglio Nazionale delle Ricerche; Italia. Università degli Studi di Bari; ItaliaFil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Fernández, Juan. Clínica Vetoncologia; ArgentinaFil: Signori, Emanuela. Consiglio Nazionale Delle Ricerche. Departimento Di Medicina. Instituto Di Farmacología Traslazionale; ItaliaFil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaMultidisciplinary Digital Publishing Institute2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170764Maglietti, Felipe Horacio; Tellado, Matías; De Robertis, Mariangela; Michinski, Sebastián Diego; Fernández, Juan; et al.; Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America; Multidisciplinary Digital Publishing Institute; Vaccines; 8; 3; 9-2020; 1-192076-393XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-393X/8/3/537info:eu-repo/semantics/altIdentifier/doi/10.3390/vaccines8030537info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:09:40Zoai:ri.conicet.gov.ar:11336/170764instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:09:41.046CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
title Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
spellingShingle Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
Maglietti, Felipe Horacio
CANCER
COMPANION ANIMALS
ELECTROCHEMOTHERAPY
GENE ELECTROTRANSFER
GENE THERAPY
IMMUNE RESPONSE
TUMOR
title_short Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
title_full Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
title_fullStr Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
title_full_unstemmed Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
title_sort Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America
dc.creator.none.fl_str_mv Maglietti, Felipe Horacio
Tellado, Matías
De Robertis, Mariangela
Michinski, Sebastián Diego
Fernández, Juan
Signori, Emanuela
Marshall, Guillermo Ricardo
author Maglietti, Felipe Horacio
author_facet Maglietti, Felipe Horacio
Tellado, Matías
De Robertis, Mariangela
Michinski, Sebastián Diego
Fernández, Juan
Signori, Emanuela
Marshall, Guillermo Ricardo
author_role author
author2 Tellado, Matías
De Robertis, Mariangela
Michinski, Sebastián Diego
Fernández, Juan
Signori, Emanuela
Marshall, Guillermo Ricardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER
COMPANION ANIMALS
ELECTROCHEMOTHERAPY
GENE ELECTROTRANSFER
GENE THERAPY
IMMUNE RESPONSE
TUMOR
topic CANCER
COMPANION ANIMALS
ELECTROCHEMOTHERAPY
GENE ELECTROTRANSFER
GENE THERAPY
IMMUNE RESPONSE
TUMOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in human and veterinary medicine. It induces a local yet robust immune response that is responsible for its high effectiveness. Gene electrotransfer (GET), used in research to produce a systemic immune response against cancer, is another electroporation-based treatment that is very appealing for its effectiveness, low cost, and simplicity. In this review, we present the immune effect of electroporation-based treatments and analyze the results of the vast majority of the published papers related to immune response enhancement by gene electrotransfer in companion animals with spontaneous tumors. In addition, we present a brief history of the initial steps and the state of the art of the electroporation-based treatments in Latin America. They have the potential to become an essential form of immunotherapy in the region. This review gives insight into the subject and helps to choose promising research lines for future work; it also helps to select the adequate treatment parameters for performing a successful application of this technology.
Fil: Maglietti, Felipe Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
Fil: Tellado, Matías. Clínica Vetoncologia; Argentina
Fil: De Robertis, Mariangela. Consiglio Nazionale delle Ricerche; Italia. Università degli Studi di Bari; Italia
Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Fernández, Juan. Clínica Vetoncologia; Argentina
Fil: Signori, Emanuela. Consiglio Nazionale Delle Ricerche. Departimento Di Medicina. Instituto Di Farmacología Traslazionale; Italia
Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
description Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in human and veterinary medicine. It induces a local yet robust immune response that is responsible for its high effectiveness. Gene electrotransfer (GET), used in research to produce a systemic immune response against cancer, is another electroporation-based treatment that is very appealing for its effectiveness, low cost, and simplicity. In this review, we present the immune effect of electroporation-based treatments and analyze the results of the vast majority of the published papers related to immune response enhancement by gene electrotransfer in companion animals with spontaneous tumors. In addition, we present a brief history of the initial steps and the state of the art of the electroporation-based treatments in Latin America. They have the potential to become an essential form of immunotherapy in the region. This review gives insight into the subject and helps to choose promising research lines for future work; it also helps to select the adequate treatment parameters for performing a successful application of this technology.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170764
Maglietti, Felipe Horacio; Tellado, Matías; De Robertis, Mariangela; Michinski, Sebastián Diego; Fernández, Juan; et al.; Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America; Multidisciplinary Digital Publishing Institute; Vaccines; 8; 3; 9-2020; 1-19
2076-393X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170764
identifier_str_mv Maglietti, Felipe Horacio; Tellado, Matías; De Robertis, Mariangela; Michinski, Sebastián Diego; Fernández, Juan; et al.; Electroporation as the immunotherapy strategy for cancer in veterinary medicine: state of the art in Latin America; Multidisciplinary Digital Publishing Institute; Vaccines; 8; 3; 9-2020; 1-19
2076-393X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-393X/8/3/537
info:eu-repo/semantics/altIdentifier/doi/10.3390/vaccines8030537
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1858305382812745728
score 13.176822

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