Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice

Autores
Sain, Juliana; González, Marcela Aída; Lavandera, Jimena Veronica; Scalerandi, María Victoria; Bernal, Claudio Adrian
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomer and the proportion of n-3/n-6/n-9 fatty acids, this work aimed to investigate the influence of different oils on the following parameters: content, incorporation and retention of TFA; conversion of vaccenic acid to rumenic acid in different tissues; and hepatic output of TFA by VLDL. Another objective was to assess relative conversion rates of key fatty acids and the potential alteration of fatty acid composition induced by TFA in tissues. Male CF1 mice were fed (30-d) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% of TFA or without added TFA. Fatty acid composition of liver, epididymal adipose tissue, gastrocnemius muscle, brain and serum was assessed. With the exception of the brain, TFA were incorporated into the analyzed tissues and serum. TFA retention and rumenic acid bioconversion from vaccenic acid depended on the dietary unsaturated fatty acid proportions. The higher levels of hepatic rumenic acid in the liver of mice fed an olive oil+TFA diet could be associated with a raised D9-desaturase index. The fatty acid composition of tissues was scarcely modified by the consumption of partially hydrogenated vegetable oils (PHVO) containing similar proportions of t9-, t10-, and t11-18:1.Practical applications: The present study evaluates the interaction of hydrogenated vegetable oils with different edible oils and the impact on the FA profile and, specifically, TFA incorporation and retention in the tissues. Since the characterization of FA present in tissues might be determining the biological effects of edible fats, this study is relevant for elucidation of existing controversial findings associated with the intake of TFA and its effects on human metabolic alterations.The levels of trans fatty acids (TFA) in a particular tissue might be related to different variables including: type and level of the dietary TFA isomer; uptake, metabolization and release from the tissue, and interference with different dietary fatty acids.
Fil: Sain, Juliana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Lavandera, Jimena Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Materia
Partially Hidrogenated Vegetable Oil
Corn Oil
Rapeseed Oil
Olive Oil
Fatty Acid Metabolism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44694
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in miceSain, JulianaGonzález, Marcela AídaLavandera, Jimena VeronicaScalerandi, María VictoriaBernal, Claudio AdrianPartially Hidrogenated Vegetable OilCorn OilRapeseed OilOlive OilFatty Acid Metabolismhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomer and the proportion of n-3/n-6/n-9 fatty acids, this work aimed to investigate the influence of different oils on the following parameters: content, incorporation and retention of TFA; conversion of vaccenic acid to rumenic acid in different tissues; and hepatic output of TFA by VLDL. Another objective was to assess relative conversion rates of key fatty acids and the potential alteration of fatty acid composition induced by TFA in tissues. Male CF1 mice were fed (30-d) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% of TFA or without added TFA. Fatty acid composition of liver, epididymal adipose tissue, gastrocnemius muscle, brain and serum was assessed. With the exception of the brain, TFA were incorporated into the analyzed tissues and serum. TFA retention and rumenic acid bioconversion from vaccenic acid depended on the dietary unsaturated fatty acid proportions. The higher levels of hepatic rumenic acid in the liver of mice fed an olive oil+TFA diet could be associated with a raised D9-desaturase index. The fatty acid composition of tissues was scarcely modified by the consumption of partially hydrogenated vegetable oils (PHVO) containing similar proportions of t9-, t10-, and t11-18:1.Practical applications: The present study evaluates the interaction of hydrogenated vegetable oils with different edible oils and the impact on the FA profile and, specifically, TFA incorporation and retention in the tissues. Since the characterization of FA present in tissues might be determining the biological effects of edible fats, this study is relevant for elucidation of existing controversial findings associated with the intake of TFA and its effects on human metabolic alterations.The levels of trans fatty acids (TFA) in a particular tissue might be related to different variables including: type and level of the dietary TFA isomer; uptake, metabolization and release from the tissue, and interference with different dietary fatty acids.Fil: Sain, Juliana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Lavandera, Jimena Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaWiley VCH Verlag2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44694Sain, Juliana; González, Marcela Aída; Lavandera, Jimena Veronica; Scalerandi, María Victoria; Bernal, Claudio Adrian; Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 8; 8-2015; 1146-11581438-7697CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ejlt.201400287info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.201400287info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T12:54:35Zoai:ri.conicet.gov.ar:11336/44694instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 12:54:35.468CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
title Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
spellingShingle Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
Sain, Juliana
Partially Hidrogenated Vegetable Oil
Corn Oil
Rapeseed Oil
Olive Oil
Fatty Acid Metabolism
title_short Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
title_full Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
title_fullStr Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
title_full_unstemmed Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
title_sort Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice
dc.creator.none.fl_str_mv Sain, Juliana
González, Marcela Aída
Lavandera, Jimena Veronica
Scalerandi, María Victoria
Bernal, Claudio Adrian
author Sain, Juliana
author_facet Sain, Juliana
González, Marcela Aída
Lavandera, Jimena Veronica
Scalerandi, María Victoria
Bernal, Claudio Adrian
author_role author
author2 González, Marcela Aída
Lavandera, Jimena Veronica
Scalerandi, María Victoria
Bernal, Claudio Adrian
author2_role author
author
author
author
dc.subject.none.fl_str_mv Partially Hidrogenated Vegetable Oil
Corn Oil
Rapeseed Oil
Olive Oil
Fatty Acid Metabolism
topic Partially Hidrogenated Vegetable Oil
Corn Oil
Rapeseed Oil
Olive Oil
Fatty Acid Metabolism
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomer and the proportion of n-3/n-6/n-9 fatty acids, this work aimed to investigate the influence of different oils on the following parameters: content, incorporation and retention of TFA; conversion of vaccenic acid to rumenic acid in different tissues; and hepatic output of TFA by VLDL. Another objective was to assess relative conversion rates of key fatty acids and the potential alteration of fatty acid composition induced by TFA in tissues. Male CF1 mice were fed (30-d) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% of TFA or without added TFA. Fatty acid composition of liver, epididymal adipose tissue, gastrocnemius muscle, brain and serum was assessed. With the exception of the brain, TFA were incorporated into the analyzed tissues and serum. TFA retention and rumenic acid bioconversion from vaccenic acid depended on the dietary unsaturated fatty acid proportions. The higher levels of hepatic rumenic acid in the liver of mice fed an olive oil+TFA diet could be associated with a raised D9-desaturase index. The fatty acid composition of tissues was scarcely modified by the consumption of partially hydrogenated vegetable oils (PHVO) containing similar proportions of t9-, t10-, and t11-18:1.Practical applications: The present study evaluates the interaction of hydrogenated vegetable oils with different edible oils and the impact on the FA profile and, specifically, TFA incorporation and retention in the tissues. Since the characterization of FA present in tissues might be determining the biological effects of edible fats, this study is relevant for elucidation of existing controversial findings associated with the intake of TFA and its effects on human metabolic alterations.The levels of trans fatty acids (TFA) in a particular tissue might be related to different variables including: type and level of the dietary TFA isomer; uptake, metabolization and release from the tissue, and interference with different dietary fatty acids.
Fil: Sain, Juliana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Lavandera, Jimena Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
description Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomer and the proportion of n-3/n-6/n-9 fatty acids, this work aimed to investigate the influence of different oils on the following parameters: content, incorporation and retention of TFA; conversion of vaccenic acid to rumenic acid in different tissues; and hepatic output of TFA by VLDL. Another objective was to assess relative conversion rates of key fatty acids and the potential alteration of fatty acid composition induced by TFA in tissues. Male CF1 mice were fed (30-d) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% of TFA or without added TFA. Fatty acid composition of liver, epididymal adipose tissue, gastrocnemius muscle, brain and serum was assessed. With the exception of the brain, TFA were incorporated into the analyzed tissues and serum. TFA retention and rumenic acid bioconversion from vaccenic acid depended on the dietary unsaturated fatty acid proportions. The higher levels of hepatic rumenic acid in the liver of mice fed an olive oil+TFA diet could be associated with a raised D9-desaturase index. The fatty acid composition of tissues was scarcely modified by the consumption of partially hydrogenated vegetable oils (PHVO) containing similar proportions of t9-, t10-, and t11-18:1.Practical applications: The present study evaluates the interaction of hydrogenated vegetable oils with different edible oils and the impact on the FA profile and, specifically, TFA incorporation and retention in the tissues. Since the characterization of FA present in tissues might be determining the biological effects of edible fats, this study is relevant for elucidation of existing controversial findings associated with the intake of TFA and its effects on human metabolic alterations.The levels of trans fatty acids (TFA) in a particular tissue might be related to different variables including: type and level of the dietary TFA isomer; uptake, metabolization and release from the tissue, and interference with different dietary fatty acids.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44694
Sain, Juliana; González, Marcela Aída; Lavandera, Jimena Veronica; Scalerandi, María Victoria; Bernal, Claudio Adrian; Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 8; 8-2015; 1146-1158
1438-7697
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44694
identifier_str_mv Sain, Juliana; González, Marcela Aída; Lavandera, Jimena Veronica; Scalerandi, María Victoria; Bernal, Claudio Adrian; Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 8; 8-2015; 1146-1158
1438-7697
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/ejlt.201400287
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.201400287
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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application/pdf
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dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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