Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak

Autores
Mariojouls, Jorge; Castro, Gonzalo; Pisano, María Belén; Barbero, Paula; Fantilli, Anabella Clara; Borda, Mariel Alejandra; Canna, Fernando; Barbás, Gabriela; Ré, Viviana Elizabeth
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During June-2016 - May-2017, several outbreaks of HA were recorded in Europe, especially described in MSM. In our area since July-2017, an increase of hepatitis A (HA) notification was reported. In order to understand the unusual increase of cases occurred in the central region of Argentina, the aim of this study was to describe, characterize and contextualize epidemiologically the HA outbreak occurred this area, until April 2018. Study designHA cases (positive anti-HAV IgM) obtained from the calendar week 29/2017 in which the first case of MSM was recognized were included in our study. HAV RNA detection and molecular characterization was performed from serum samples and / or stool by RT - PCR of VP1 / 2A genomic region (360bp).ResultsOf the 32 cases notified, 87.5% of them were unvaccinated men and 69.6% were MSM (mean age 31.9 years). All MSM associated HAV sequences were genotyped as IA, and clustered with the VRD 521-2016 strain, responsible of causing outbreaks mostly in MSM in Europe since mid-2016. As a consequence of the implementation of immunization in children, and the improvement in socio-economic, hygienic and sanitation factors, young adults are becoming increasingly susceptible to HAV infections. Here we add evidence in South America to the HA outbreaks described worldwide among young MSM, demonstrating the need to reinforce official policy of vaccination, in this group and adjust epidemiological surveillance, catch-up vaccination for adolescents, young adults and immuno suppressed patients.
Fil: Mariojouls, Jorge. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Castro, Gonzalo. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Barbero, Paula. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Fantilli, Anabella Clara. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borda, Mariel Alejandra. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Canna, Fernando. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Barbás, Gabriela. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Materia
HEPATITIS A
HAV SURVEILLANCE
OUTBREAK
MSM
GENOTYPING
ARGENTINA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/106707
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/106707
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreakMariojouls, JorgeCastro, GonzaloPisano, María BelénBarbero, PaulaFantilli, Anabella ClaraBorda, Mariel AlejandraCanna, FernandoBarbás, GabrielaRé, Viviana ElizabethHEPATITIS AHAV SURVEILLANCEOUTBREAKMSMGENOTYPINGARGENTINAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3During June-2016 - May-2017, several outbreaks of HA were recorded in Europe, especially described in MSM. In our area since July-2017, an increase of hepatitis A (HA) notification was reported. In order to understand the unusual increase of cases occurred in the central region of Argentina, the aim of this study was to describe, characterize and contextualize epidemiologically the HA outbreak occurred this area, until April 2018. Study designHA cases (positive anti-HAV IgM) obtained from the calendar week 29/2017 in which the first case of MSM was recognized were included in our study. HAV RNA detection and molecular characterization was performed from serum samples and / or stool by RT - PCR of VP1 / 2A genomic region (360bp).ResultsOf the 32 cases notified, 87.5% of them were unvaccinated men and 69.6% were MSM (mean age 31.9 years). All MSM associated HAV sequences were genotyped as IA, and clustered with the VRD 521-2016 strain, responsible of causing outbreaks mostly in MSM in Europe since mid-2016. As a consequence of the implementation of immunization in children, and the improvement in socio-economic, hygienic and sanitation factors, young adults are becoming increasingly susceptible to HAV infections. Here we add evidence in South America to the HA outbreaks described worldwide among young MSM, demonstrating the need to reinforce official policy of vaccination, in this group and adjust epidemiological surveillance, catch-up vaccination for adolescents, young adults and immuno suppressed patients.Fil: Mariojouls, Jorge. Laboratorio Central de la Provincia de Cordoba; ArgentinaFil: Castro, Gonzalo. Laboratorio Central de la Provincia de Cordoba; ArgentinaFil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Barbero, Paula. Laboratorio Central de la Provincia de Cordoba; ArgentinaFil: Fantilli, Anabella Clara. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Borda, Mariel Alejandra. Laboratorio Central de la Provincia de Cordoba; ArgentinaFil: Canna, Fernando. Laboratorio Central de la Provincia de Cordoba; ArgentinaFil: Barbás, Gabriela. Laboratorio Central de la Provincia de Cordoba; ArgentinaFil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaElsevier Science2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106707Mariojouls, Jorge; Castro, Gonzalo; Pisano, María Belén; Barbero, Paula; Fantilli, Anabella Clara; et al.; Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak; Elsevier Science; Journal of Clinical Virology; 117; 5-2019; 49-531386-6532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1386653219301337info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2019.05.014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:09Zoai:ri.conicet.gov.ar:11336/106707instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:10.076CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
title Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
spellingShingle Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
Mariojouls, Jorge
HEPATITIS A
HAV SURVEILLANCE
OUTBREAK
MSM
GENOTYPING
ARGENTINA
title_short Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
title_full Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
title_fullStr Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
title_full_unstemmed Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
title_sort Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
dc.creator.none.fl_str_mv Mariojouls, Jorge
Castro, Gonzalo
Pisano, María Belén
Barbero, Paula
Fantilli, Anabella Clara
Borda, Mariel Alejandra
Canna, Fernando
Barbás, Gabriela
Ré, Viviana Elizabeth
author Mariojouls, Jorge
author_facet Mariojouls, Jorge
Castro, Gonzalo
Pisano, María Belén
Barbero, Paula
Fantilli, Anabella Clara
Borda, Mariel Alejandra
Canna, Fernando
Barbás, Gabriela
Ré, Viviana Elizabeth
author_role author
author2 Castro, Gonzalo
Pisano, María Belén
Barbero, Paula
Fantilli, Anabella Clara
Borda, Mariel Alejandra
Canna, Fernando
Barbás, Gabriela
Ré, Viviana Elizabeth
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HEPATITIS A
HAV SURVEILLANCE
OUTBREAK
MSM
GENOTYPING
ARGENTINA
topic HEPATITIS A
HAV SURVEILLANCE
OUTBREAK
MSM
GENOTYPING
ARGENTINA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv During June-2016 - May-2017, several outbreaks of HA were recorded in Europe, especially described in MSM. In our area since July-2017, an increase of hepatitis A (HA) notification was reported. In order to understand the unusual increase of cases occurred in the central region of Argentina, the aim of this study was to describe, characterize and contextualize epidemiologically the HA outbreak occurred this area, until April 2018. Study designHA cases (positive anti-HAV IgM) obtained from the calendar week 29/2017 in which the first case of MSM was recognized were included in our study. HAV RNA detection and molecular characterization was performed from serum samples and / or stool by RT - PCR of VP1 / 2A genomic region (360bp).ResultsOf the 32 cases notified, 87.5% of them were unvaccinated men and 69.6% were MSM (mean age 31.9 years). All MSM associated HAV sequences were genotyped as IA, and clustered with the VRD 521-2016 strain, responsible of causing outbreaks mostly in MSM in Europe since mid-2016. As a consequence of the implementation of immunization in children, and the improvement in socio-economic, hygienic and sanitation factors, young adults are becoming increasingly susceptible to HAV infections. Here we add evidence in South America to the HA outbreaks described worldwide among young MSM, demonstrating the need to reinforce official policy of vaccination, in this group and adjust epidemiological surveillance, catch-up vaccination for adolescents, young adults and immuno suppressed patients.
Fil: Mariojouls, Jorge. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Castro, Gonzalo. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Barbero, Paula. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Fantilli, Anabella Clara. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borda, Mariel Alejandra. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Canna, Fernando. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Barbás, Gabriela. Laboratorio Central de la Provincia de Cordoba; Argentina
Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
description During June-2016 - May-2017, several outbreaks of HA were recorded in Europe, especially described in MSM. In our area since July-2017, an increase of hepatitis A (HA) notification was reported. In order to understand the unusual increase of cases occurred in the central region of Argentina, the aim of this study was to describe, characterize and contextualize epidemiologically the HA outbreak occurred this area, until April 2018. Study designHA cases (positive anti-HAV IgM) obtained from the calendar week 29/2017 in which the first case of MSM was recognized were included in our study. HAV RNA detection and molecular characterization was performed from serum samples and / or stool by RT - PCR of VP1 / 2A genomic region (360bp).ResultsOf the 32 cases notified, 87.5% of them were unvaccinated men and 69.6% were MSM (mean age 31.9 years). All MSM associated HAV sequences were genotyped as IA, and clustered with the VRD 521-2016 strain, responsible of causing outbreaks mostly in MSM in Europe since mid-2016. As a consequence of the implementation of immunization in children, and the improvement in socio-economic, hygienic and sanitation factors, young adults are becoming increasingly susceptible to HAV infections. Here we add evidence in South America to the HA outbreaks described worldwide among young MSM, demonstrating the need to reinforce official policy of vaccination, in this group and adjust epidemiological surveillance, catch-up vaccination for adolescents, young adults and immuno suppressed patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/106707
Mariojouls, Jorge; Castro, Gonzalo; Pisano, María Belén; Barbero, Paula; Fantilli, Anabella Clara; et al.; Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak; Elsevier Science; Journal of Clinical Virology; 117; 5-2019; 49-53
1386-6532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/106707
identifier_str_mv Mariojouls, Jorge; Castro, Gonzalo; Pisano, María Belén; Barbero, Paula; Fantilli, Anabella Clara; et al.; Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak; Elsevier Science; Journal of Clinical Virology; 117; 5-2019; 49-53
1386-6532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1386653219301337
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2019.05.014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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