The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America

Autores
Picado, Albert; Cruz, Israel; Redard Jacot, Maël; Schijman, Alejandro Gabriel; Torrico, Faustino; Sosa-Estani, Sergio Alejandro; Katz, Zachary; Ndung'u, Joseph Mathu
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy at birth and serology at 8-12 months after delivery, is one of the barriers to congenital Chagas disease (CCD) control. Detection of parasite DNA using molecular diagnostic tools could be an alternative or complement to current diagnostic methods, but its implementation in endemic regions remains limited. Prompt diagnosis and treatment of CCD cases would have a positive clinical and epidemiological impact. In this paper, we analysed the burden of CCD in Latin America, and the potential use of molecular tests to improve access to early diagnosis and treatment of T. cruzi infected newborns.
Fil: Picado, Albert. Foundation for Innovative New Diagnostics; Suiza
Fil: Cruz, Israel. Foundation for Innovative New Diagnostics; Suiza
Fil: Redard Jacot, Maël. Foundation for Innovative New Diagnostics; Suiza
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Torrico, Faustino. Universidad Mayor de San Simón; Bolivia. Fundación CEADES; Bolivia
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Drugs for Neglected Diseases initiative; Brasil
Fil: Katz, Zachary. Foundation for Innovative New Diagnostics; Suiza
Fil: Ndung'u, Joseph Mathu. Foundation for Innovative New Diagnostics; Suiza
Materia
LAMP
MOLECULAR TOOLS
TRYPANOSOMA CRUZI
CHAGAS DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79859
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/79859
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin AmericaPicado, AlbertCruz, IsraelRedard Jacot, MaëlSchijman, Alejandro GabrielTorrico, FaustinoSosa-Estani, Sergio AlejandroKatz, ZacharyNdung'u, Joseph MathuLAMPMOLECULAR TOOLSTRYPANOSOMA CRUZICHAGAS DISEASEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy at birth and serology at 8-12 months after delivery, is one of the barriers to congenital Chagas disease (CCD) control. Detection of parasite DNA using molecular diagnostic tools could be an alternative or complement to current diagnostic methods, but its implementation in endemic regions remains limited. Prompt diagnosis and treatment of CCD cases would have a positive clinical and epidemiological impact. In this paper, we analysed the burden of CCD in Latin America, and the potential use of molecular tests to improve access to early diagnosis and treatment of T. cruzi infected newborns.Fil: Picado, Albert. Foundation for Innovative New Diagnostics; SuizaFil: Cruz, Israel. Foundation for Innovative New Diagnostics; SuizaFil: Redard Jacot, Maël. Foundation for Innovative New Diagnostics; SuizaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Torrico, Faustino. Universidad Mayor de San Simón; Bolivia. Fundación CEADES; BoliviaFil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Drugs for Neglected Diseases initiative; BrasilFil: Katz, Zachary. Foundation for Innovative New Diagnostics; SuizaFil: Ndung'u, Joseph Mathu. Foundation for Innovative New Diagnostics; SuizaBMJ Publishing Group2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79859Picado, Albert; Cruz, Israel; Redard Jacot, Maël; Schijman, Alejandro Gabriel; Torrico, Faustino; et al.; The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America; BMJ Publishing Group; BMJ Global Health; 3; 5; 10-2018; 1-72059-79080959-535XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://gh.bmj.com/content/3/5/e001069info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjgh-2018-001069info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:19Zoai:ri.conicet.gov.ar:11336/79859instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:19.47CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
title The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
spellingShingle The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
Picado, Albert
LAMP
MOLECULAR TOOLS
TRYPANOSOMA CRUZI
CHAGAS DISEASE
title_short The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
title_full The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
title_fullStr The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
title_full_unstemmed The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
title_sort The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
dc.creator.none.fl_str_mv Picado, Albert
Cruz, Israel
Redard Jacot, Maël
Schijman, Alejandro Gabriel
Torrico, Faustino
Sosa-Estani, Sergio Alejandro
Katz, Zachary
Ndung'u, Joseph Mathu
author Picado, Albert
author_facet Picado, Albert
Cruz, Israel
Redard Jacot, Maël
Schijman, Alejandro Gabriel
Torrico, Faustino
Sosa-Estani, Sergio Alejandro
Katz, Zachary
Ndung'u, Joseph Mathu
author_role author
author2 Cruz, Israel
Redard Jacot, Maël
Schijman, Alejandro Gabriel
Torrico, Faustino
Sosa-Estani, Sergio Alejandro
Katz, Zachary
Ndung'u, Joseph Mathu
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LAMP
MOLECULAR TOOLS
TRYPANOSOMA CRUZI
CHAGAS DISEASE
topic LAMP
MOLECULAR TOOLS
TRYPANOSOMA CRUZI
CHAGAS DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy at birth and serology at 8-12 months after delivery, is one of the barriers to congenital Chagas disease (CCD) control. Detection of parasite DNA using molecular diagnostic tools could be an alternative or complement to current diagnostic methods, but its implementation in endemic regions remains limited. Prompt diagnosis and treatment of CCD cases would have a positive clinical and epidemiological impact. In this paper, we analysed the burden of CCD in Latin America, and the potential use of molecular tests to improve access to early diagnosis and treatment of T. cruzi infected newborns.
Fil: Picado, Albert. Foundation for Innovative New Diagnostics; Suiza
Fil: Cruz, Israel. Foundation for Innovative New Diagnostics; Suiza
Fil: Redard Jacot, Maël. Foundation for Innovative New Diagnostics; Suiza
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Torrico, Faustino. Universidad Mayor de San Simón; Bolivia. Fundación CEADES; Bolivia
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Drugs for Neglected Diseases initiative; Brasil
Fil: Katz, Zachary. Foundation for Innovative New Diagnostics; Suiza
Fil: Ndung'u, Joseph Mathu. Foundation for Innovative New Diagnostics; Suiza
description It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy at birth and serology at 8-12 months after delivery, is one of the barriers to congenital Chagas disease (CCD) control. Detection of parasite DNA using molecular diagnostic tools could be an alternative or complement to current diagnostic methods, but its implementation in endemic regions remains limited. Prompt diagnosis and treatment of CCD cases would have a positive clinical and epidemiological impact. In this paper, we analysed the burden of CCD in Latin America, and the potential use of molecular tests to improve access to early diagnosis and treatment of T. cruzi infected newborns.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79859
Picado, Albert; Cruz, Israel; Redard Jacot, Maël; Schijman, Alejandro Gabriel; Torrico, Faustino; et al.; The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America; BMJ Publishing Group; BMJ Global Health; 3; 5; 10-2018; 1-7
2059-7908
0959-535X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79859
identifier_str_mv Picado, Albert; Cruz, Israel; Redard Jacot, Maël; Schijman, Alejandro Gabriel; Torrico, Faustino; et al.; The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America; BMJ Publishing Group; BMJ Global Health; 3; 5; 10-2018; 1-7
2059-7908
0959-535X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://gh.bmj.com/content/3/5/e001069
info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjgh-2018-001069
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614467983245312
score 13.070432

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