Inflammatory cell recruitment in cardiovascular disease
- Autores
- Marchini, Timoteo Oscar; Mitre, Lucía Sol; Wolf, Dennis
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Atherosclerosis, the main underlying pathology for myocardial infarction and stroke, is a chronic inflammatory disease of middle-sized to large arteries that is initiated and maintained by leukocytes infiltrating into the subendothelial space. It is now clear that the accumulation of pro-inflammatory leukocytes drives progression of atherosclerosis, its clinical complications, and directly modulates tissue-healing in the infarcted heart after myocardial infarction. This inflammatory response is orchestrated by multiple soluble mediators that enhance inflammation systemically and locally, as well as by a multitude of partially tissue-specific molecules that regulate homing, adhesion, and transmigration of leukocytes. While numerous experimental studies in the mouse have refined our understanding of leukocyte accumulation from a conceptual perspective, only a few anti-leukocyte therapies have been directly validated in humans. Lack of tissue-tropism of targeted factors required for leukocyte accumulation and unspecific inhibition strategies remain the major challenges to ultimately translate therapies that modulate leukocytes accumulation into clinical practice. Here, we carefully describe receptor and ligand pairs that guide leukocyte accumulation into the atherosclerotic plaque and the infarcted myocardium, and comment on potential future medical therapies.
Fil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; Alemania
Fil: Mitre, Lucía Sol. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; Alemania
Fil: Wolf, Dennis. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; Alemania - Materia
-
ATHEROSCLEROSIS
CHEMOKINE
CYTOKINE
INTEGRIN
LEUKOCYTE
MYOCARDIAL INFARCTION
RECRUITMENT
SELECTIN - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/181973
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Inflammatory cell recruitment in cardiovascular diseaseMarchini, Timoteo OscarMitre, Lucía SolWolf, DennisATHEROSCLEROSISCHEMOKINECYTOKINEINTEGRINLEUKOCYTEMYOCARDIAL INFARCTIONRECRUITMENTSELECTINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Atherosclerosis, the main underlying pathology for myocardial infarction and stroke, is a chronic inflammatory disease of middle-sized to large arteries that is initiated and maintained by leukocytes infiltrating into the subendothelial space. It is now clear that the accumulation of pro-inflammatory leukocytes drives progression of atherosclerosis, its clinical complications, and directly modulates tissue-healing in the infarcted heart after myocardial infarction. This inflammatory response is orchestrated by multiple soluble mediators that enhance inflammation systemically and locally, as well as by a multitude of partially tissue-specific molecules that regulate homing, adhesion, and transmigration of leukocytes. While numerous experimental studies in the mouse have refined our understanding of leukocyte accumulation from a conceptual perspective, only a few anti-leukocyte therapies have been directly validated in humans. Lack of tissue-tropism of targeted factors required for leukocyte accumulation and unspecific inhibition strategies remain the major challenges to ultimately translate therapies that modulate leukocytes accumulation into clinical practice. Here, we carefully describe receptor and ligand pairs that guide leukocyte accumulation into the atherosclerotic plaque and the infarcted myocardium, and comment on potential future medical therapies.Fil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; AlemaniaFil: Mitre, Lucía Sol. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; AlemaniaFil: Wolf, Dennis. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; AlemaniaFrontiers Media2021-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181973Marchini, Timoteo Oscar; Mitre, Lucía Sol; Wolf, Dennis; Inflammatory cell recruitment in cardiovascular disease; Frontiers Media; Frontiers in Cell and Developmental Biology; 9; 2-2021; 1-122296-634XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2021.635527/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2021.635527info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:22Zoai:ri.conicet.gov.ar:11336/181973instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:22.788CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Inflammatory cell recruitment in cardiovascular disease |
title |
Inflammatory cell recruitment in cardiovascular disease |
spellingShingle |
Inflammatory cell recruitment in cardiovascular disease Marchini, Timoteo Oscar ATHEROSCLEROSIS CHEMOKINE CYTOKINE INTEGRIN LEUKOCYTE MYOCARDIAL INFARCTION RECRUITMENT SELECTIN |
title_short |
Inflammatory cell recruitment in cardiovascular disease |
title_full |
Inflammatory cell recruitment in cardiovascular disease |
title_fullStr |
Inflammatory cell recruitment in cardiovascular disease |
title_full_unstemmed |
Inflammatory cell recruitment in cardiovascular disease |
title_sort |
Inflammatory cell recruitment in cardiovascular disease |
dc.creator.none.fl_str_mv |
Marchini, Timoteo Oscar Mitre, Lucía Sol Wolf, Dennis |
author |
Marchini, Timoteo Oscar |
author_facet |
Marchini, Timoteo Oscar Mitre, Lucía Sol Wolf, Dennis |
author_role |
author |
author2 |
Mitre, Lucía Sol Wolf, Dennis |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ATHEROSCLEROSIS CHEMOKINE CYTOKINE INTEGRIN LEUKOCYTE MYOCARDIAL INFARCTION RECRUITMENT SELECTIN |
topic |
ATHEROSCLEROSIS CHEMOKINE CYTOKINE INTEGRIN LEUKOCYTE MYOCARDIAL INFARCTION RECRUITMENT SELECTIN |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Atherosclerosis, the main underlying pathology for myocardial infarction and stroke, is a chronic inflammatory disease of middle-sized to large arteries that is initiated and maintained by leukocytes infiltrating into the subendothelial space. It is now clear that the accumulation of pro-inflammatory leukocytes drives progression of atherosclerosis, its clinical complications, and directly modulates tissue-healing in the infarcted heart after myocardial infarction. This inflammatory response is orchestrated by multiple soluble mediators that enhance inflammation systemically and locally, as well as by a multitude of partially tissue-specific molecules that regulate homing, adhesion, and transmigration of leukocytes. While numerous experimental studies in the mouse have refined our understanding of leukocyte accumulation from a conceptual perspective, only a few anti-leukocyte therapies have been directly validated in humans. Lack of tissue-tropism of targeted factors required for leukocyte accumulation and unspecific inhibition strategies remain the major challenges to ultimately translate therapies that modulate leukocytes accumulation into clinical practice. Here, we carefully describe receptor and ligand pairs that guide leukocyte accumulation into the atherosclerotic plaque and the infarcted myocardium, and comment on potential future medical therapies. Fil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; Alemania Fil: Mitre, Lucía Sol. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; Alemania Fil: Wolf, Dennis. Albert Ludwigs University of Freiburg; Alemania. University Heart Center Freiburg; Alemania |
description |
Atherosclerosis, the main underlying pathology for myocardial infarction and stroke, is a chronic inflammatory disease of middle-sized to large arteries that is initiated and maintained by leukocytes infiltrating into the subendothelial space. It is now clear that the accumulation of pro-inflammatory leukocytes drives progression of atherosclerosis, its clinical complications, and directly modulates tissue-healing in the infarcted heart after myocardial infarction. This inflammatory response is orchestrated by multiple soluble mediators that enhance inflammation systemically and locally, as well as by a multitude of partially tissue-specific molecules that regulate homing, adhesion, and transmigration of leukocytes. While numerous experimental studies in the mouse have refined our understanding of leukocyte accumulation from a conceptual perspective, only a few anti-leukocyte therapies have been directly validated in humans. Lack of tissue-tropism of targeted factors required for leukocyte accumulation and unspecific inhibition strategies remain the major challenges to ultimately translate therapies that modulate leukocytes accumulation into clinical practice. Here, we carefully describe receptor and ligand pairs that guide leukocyte accumulation into the atherosclerotic plaque and the infarcted myocardium, and comment on potential future medical therapies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/181973 Marchini, Timoteo Oscar; Mitre, Lucía Sol; Wolf, Dennis; Inflammatory cell recruitment in cardiovascular disease; Frontiers Media; Frontiers in Cell and Developmental Biology; 9; 2-2021; 1-12 2296-634X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/181973 |
identifier_str_mv |
Marchini, Timoteo Oscar; Mitre, Lucía Sol; Wolf, Dennis; Inflammatory cell recruitment in cardiovascular disease; Frontiers Media; Frontiers in Cell and Developmental Biology; 9; 2-2021; 1-12 2296-634X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2021.635527/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2021.635527 |
dc.rights.none.fl_str_mv |
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openAccess |
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https://creativecommons.org/licenses/by/2.5/ar/ |
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application/pdf application/pdf |
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Frontiers Media |
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Frontiers Media |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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