Autonomic neural signals in bone: Physiological implications for mandible and dental growth

Autores
Boggio, Veronica Ines; Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Cardinali, Daniel Pedro
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Signals derived from the autonomic nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous sympathetic and sensory innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones and neurotransmitters and their receptors are detectable in bone. Bone mineral content decreased in sympathetically denervated mandibular bone. When a mechanical stress was superimposed on mandibular bone by cutting out the lower incisors, an increase in bone density ensued providing the sympathetic innervation was intact. A lower eruption rate of sympathetically denervated incisors at the impeded eruption side, and a higher eruption rate of denervated incisors at the unimpeded side were also observed. A normal sympathetic neural activity appears to be a pre-requisite for maintaining a minimal normal unimpeded incisor eruption and for keeping the unimpeded eruption to attain abnormally high velocities under conditions of stimulated incisor growth. These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism.
Fil: Boggio, Veronica Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ladizesky, Marta Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
AUTONOMIC INNERVATION
BONE METABOLISM
NEUROPEPTIDES
NEUROTRANSMITTERS
SUPERIOR CERVICAL GANGLION
SYMPATHECTOMY
TOOTH ERUPTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162607
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/162607
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Autonomic neural signals in bone: Physiological implications for mandible and dental growthBoggio, Veronica InesLadizesky, Marta GracielaCutrera, Rodolfo AngelCardinali, Daniel PedroAUTONOMIC INNERVATIONBONE METABOLISMNEUROPEPTIDESNEUROTRANSMITTERSSUPERIOR CERVICAL GANGLIONSYMPATHECTOMYTOOTH ERUPTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Signals derived from the autonomic nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous sympathetic and sensory innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones and neurotransmitters and their receptors are detectable in bone. Bone mineral content decreased in sympathetically denervated mandibular bone. When a mechanical stress was superimposed on mandibular bone by cutting out the lower incisors, an increase in bone density ensued providing the sympathetic innervation was intact. A lower eruption rate of sympathetically denervated incisors at the impeded eruption side, and a higher eruption rate of denervated incisors at the unimpeded side were also observed. A normal sympathetic neural activity appears to be a pre-requisite for maintaining a minimal normal unimpeded incisor eruption and for keeping the unimpeded eruption to attain abnormally high velocities under conditions of stimulated incisor growth. These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism.Fil: Boggio, Veronica Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Ladizesky, Marta Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPergamon-Elsevier Science Ltd2004-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162607Boggio, Veronica Ines; Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Cardinali, Daniel Pedro; Autonomic neural signals in bone: Physiological implications for mandible and dental growth; Pergamon-Elsevier Science Ltd; Life Sciences; 75; 4; 6-2004; 383-3950024-3205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0024320504002401info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2003.11.031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:47:09Zoai:ri.conicet.gov.ar:11336/162607instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:47:10.021CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Autonomic neural signals in bone: Physiological implications for mandible and dental growth
title Autonomic neural signals in bone: Physiological implications for mandible and dental growth
spellingShingle Autonomic neural signals in bone: Physiological implications for mandible and dental growth
Boggio, Veronica Ines
AUTONOMIC INNERVATION
BONE METABOLISM
NEUROPEPTIDES
NEUROTRANSMITTERS
SUPERIOR CERVICAL GANGLION
SYMPATHECTOMY
TOOTH ERUPTION
title_short Autonomic neural signals in bone: Physiological implications for mandible and dental growth
title_full Autonomic neural signals in bone: Physiological implications for mandible and dental growth
title_fullStr Autonomic neural signals in bone: Physiological implications for mandible and dental growth
title_full_unstemmed Autonomic neural signals in bone: Physiological implications for mandible and dental growth
title_sort Autonomic neural signals in bone: Physiological implications for mandible and dental growth
dc.creator.none.fl_str_mv Boggio, Veronica Ines
Ladizesky, Marta Graciela
Cutrera, Rodolfo Angel
Cardinali, Daniel Pedro
author Boggio, Veronica Ines
author_facet Boggio, Veronica Ines
Ladizesky, Marta Graciela
Cutrera, Rodolfo Angel
Cardinali, Daniel Pedro
author_role author
author2 Ladizesky, Marta Graciela
Cutrera, Rodolfo Angel
Cardinali, Daniel Pedro
author2_role author
author
author
dc.subject.none.fl_str_mv AUTONOMIC INNERVATION
BONE METABOLISM
NEUROPEPTIDES
NEUROTRANSMITTERS
SUPERIOR CERVICAL GANGLION
SYMPATHECTOMY
TOOTH ERUPTION
topic AUTONOMIC INNERVATION
BONE METABOLISM
NEUROPEPTIDES
NEUROTRANSMITTERS
SUPERIOR CERVICAL GANGLION
SYMPATHECTOMY
TOOTH ERUPTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Signals derived from the autonomic nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous sympathetic and sensory innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones and neurotransmitters and their receptors are detectable in bone. Bone mineral content decreased in sympathetically denervated mandibular bone. When a mechanical stress was superimposed on mandibular bone by cutting out the lower incisors, an increase in bone density ensued providing the sympathetic innervation was intact. A lower eruption rate of sympathetically denervated incisors at the impeded eruption side, and a higher eruption rate of denervated incisors at the unimpeded side were also observed. A normal sympathetic neural activity appears to be a pre-requisite for maintaining a minimal normal unimpeded incisor eruption and for keeping the unimpeded eruption to attain abnormally high velocities under conditions of stimulated incisor growth. These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism.
Fil: Boggio, Veronica Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ladizesky, Marta Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Signals derived from the autonomic nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous sympathetic and sensory innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones and neurotransmitters and their receptors are detectable in bone. Bone mineral content decreased in sympathetically denervated mandibular bone. When a mechanical stress was superimposed on mandibular bone by cutting out the lower incisors, an increase in bone density ensued providing the sympathetic innervation was intact. A lower eruption rate of sympathetically denervated incisors at the impeded eruption side, and a higher eruption rate of denervated incisors at the unimpeded side were also observed. A normal sympathetic neural activity appears to be a pre-requisite for maintaining a minimal normal unimpeded incisor eruption and for keeping the unimpeded eruption to attain abnormally high velocities under conditions of stimulated incisor growth. These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism.
publishDate 2004
dc.date.none.fl_str_mv 2004-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162607
Boggio, Veronica Ines; Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Cardinali, Daniel Pedro; Autonomic neural signals in bone: Physiological implications for mandible and dental growth; Pergamon-Elsevier Science Ltd; Life Sciences; 75; 4; 6-2004; 383-395
0024-3205
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162607
identifier_str_mv Boggio, Veronica Ines; Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Cardinali, Daniel Pedro; Autonomic neural signals in bone: Physiological implications for mandible and dental growth; Pergamon-Elsevier Science Ltd; Life Sciences; 75; 4; 6-2004; 383-395
0024-3205
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0024320504002401
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2003.11.031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782176298795008
score 12.982451

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