Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress
- Autores
- Gonzalez, Paula Natalia; Lotto, Federico Pablo; Hallgrimsson, Benedikt
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Nutritional imbalance is one of themain sources of stress in both extant and extinct humanpopulations. Restricted availability of nutrients isthought to disrupt the buffering mechanisms that con-tribute to developmental stability and canalization,resulting in increased levels of fluctuating asymmetry(FA) and phenotypic variance among individuals. How-ever, the literature is contradictory in this regard. Thisstudy assesses the effect of prenatal nutritional stresson FA and among-individual variance in cranial shapeand size using a mouse model of maternal proteinrestriction. Two sets of landmark coordinates were digi-tized in three dimensions from skulls of control and pro-tein restricted specimens at E17.5 and E18.5. We foundthat, by the end of gestation, maternal protein restric-tion resulted in a significant reduction of skull size.Fluctuating asymmetry in size and shape exceeded theamount of measurement error in all groups, but no sig-nificant differences in the magnitude of FA were foundbetween treatments. Conversely, the pattern of shapeasymmetry was affected by the environmental perturba-tion since the angles between the first eigenvectorsextracted from the covariance matrix of shape asymmet-ric component of protein restricted and control groupswere not significantly different from the expected forrandom vectors. In addition, among-individual variancein cranial shape was significantly higher in the proteinrestricted than the control group at E18.5. Overall, theresults obtained from a controlled experiment do notsupport the view of fluctuating asymmetry of cranialstructures as a reliable index for inferring nutritionalstress in human populations.
Fil: Gonzalez, Paula Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina
Fil: Lotto, Federico Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá - Materia
-
Protein Restriction
Fluctuating Asymmetry
Phenotypic Variation
Fetal Growth - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/32642
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Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional StressGonzalez, Paula NataliaLotto, Federico PabloHallgrimsson, BenediktProtein RestrictionFluctuating AsymmetryPhenotypic VariationFetal Growthhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Nutritional imbalance is one of themain sources of stress in both extant and extinct humanpopulations. Restricted availability of nutrients isthought to disrupt the buffering mechanisms that con-tribute to developmental stability and canalization,resulting in increased levels of fluctuating asymmetry(FA) and phenotypic variance among individuals. How-ever, the literature is contradictory in this regard. Thisstudy assesses the effect of prenatal nutritional stresson FA and among-individual variance in cranial shapeand size using a mouse model of maternal proteinrestriction. Two sets of landmark coordinates were digi-tized in three dimensions from skulls of control and pro-tein restricted specimens at E17.5 and E18.5. We foundthat, by the end of gestation, maternal protein restric-tion resulted in a significant reduction of skull size.Fluctuating asymmetry in size and shape exceeded theamount of measurement error in all groups, but no sig-nificant differences in the magnitude of FA were foundbetween treatments. Conversely, the pattern of shapeasymmetry was affected by the environmental perturba-tion since the angles between the first eigenvectorsextracted from the covariance matrix of shape asymmet-ric component of protein restricted and control groupswere not significantly different from the expected forrandom vectors. In addition, among-individual variancein cranial shape was significantly higher in the proteinrestricted than the control group at E18.5. Overall, theresults obtained from a controlled experiment do notsupport the view of fluctuating asymmetry of cranialstructures as a reliable index for inferring nutritionalstress in human populations.Fil: Gonzalez, Paula Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Lotto, Federico Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Hallgrimsson, Benedikt. University of Calgary; CanadáWiley-liss, Div John Wiley & Sons Inc2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32642Gonzalez, Paula Natalia; Lotto, Federico Pablo; Hallgrimsson, Benedikt; Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 154; 4; 8-2014; 544-5530002-9483CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.22545info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22545/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:05Zoai:ri.conicet.gov.ar:11336/32642instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:06.194CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
title |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
spellingShingle |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress Gonzalez, Paula Natalia Protein Restriction Fluctuating Asymmetry Phenotypic Variation Fetal Growth |
title_short |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
title_full |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
title_fullStr |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
title_full_unstemmed |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
title_sort |
Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress |
dc.creator.none.fl_str_mv |
Gonzalez, Paula Natalia Lotto, Federico Pablo Hallgrimsson, Benedikt |
author |
Gonzalez, Paula Natalia |
author_facet |
Gonzalez, Paula Natalia Lotto, Federico Pablo Hallgrimsson, Benedikt |
author_role |
author |
author2 |
Lotto, Federico Pablo Hallgrimsson, Benedikt |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Protein Restriction Fluctuating Asymmetry Phenotypic Variation Fetal Growth |
topic |
Protein Restriction Fluctuating Asymmetry Phenotypic Variation Fetal Growth |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Nutritional imbalance is one of themain sources of stress in both extant and extinct humanpopulations. Restricted availability of nutrients isthought to disrupt the buffering mechanisms that con-tribute to developmental stability and canalization,resulting in increased levels of fluctuating asymmetry(FA) and phenotypic variance among individuals. How-ever, the literature is contradictory in this regard. Thisstudy assesses the effect of prenatal nutritional stresson FA and among-individual variance in cranial shapeand size using a mouse model of maternal proteinrestriction. Two sets of landmark coordinates were digi-tized in three dimensions from skulls of control and pro-tein restricted specimens at E17.5 and E18.5. We foundthat, by the end of gestation, maternal protein restric-tion resulted in a significant reduction of skull size.Fluctuating asymmetry in size and shape exceeded theamount of measurement error in all groups, but no sig-nificant differences in the magnitude of FA were foundbetween treatments. Conversely, the pattern of shapeasymmetry was affected by the environmental perturba-tion since the angles between the first eigenvectorsextracted from the covariance matrix of shape asymmet-ric component of protein restricted and control groupswere not significantly different from the expected forrandom vectors. In addition, among-individual variancein cranial shape was significantly higher in the proteinrestricted than the control group at E18.5. Overall, theresults obtained from a controlled experiment do notsupport the view of fluctuating asymmetry of cranialstructures as a reliable index for inferring nutritionalstress in human populations. Fil: Gonzalez, Paula Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina Fil: Lotto, Federico Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá |
description |
Nutritional imbalance is one of themain sources of stress in both extant and extinct humanpopulations. Restricted availability of nutrients isthought to disrupt the buffering mechanisms that con-tribute to developmental stability and canalization,resulting in increased levels of fluctuating asymmetry(FA) and phenotypic variance among individuals. How-ever, the literature is contradictory in this regard. Thisstudy assesses the effect of prenatal nutritional stresson FA and among-individual variance in cranial shapeand size using a mouse model of maternal proteinrestriction. Two sets of landmark coordinates were digi-tized in three dimensions from skulls of control and pro-tein restricted specimens at E17.5 and E18.5. We foundthat, by the end of gestation, maternal protein restric-tion resulted in a significant reduction of skull size.Fluctuating asymmetry in size and shape exceeded theamount of measurement error in all groups, but no sig-nificant differences in the magnitude of FA were foundbetween treatments. Conversely, the pattern of shapeasymmetry was affected by the environmental perturba-tion since the angles between the first eigenvectorsextracted from the covariance matrix of shape asymmet-ric component of protein restricted and control groupswere not significantly different from the expected forrandom vectors. In addition, among-individual variancein cranial shape was significantly higher in the proteinrestricted than the control group at E18.5. Overall, theresults obtained from a controlled experiment do notsupport the view of fluctuating asymmetry of cranialstructures as a reliable index for inferring nutritionalstress in human populations. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/32642 Gonzalez, Paula Natalia; Lotto, Federico Pablo; Hallgrimsson, Benedikt; Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 154; 4; 8-2014; 544-553 0002-9483 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/32642 |
identifier_str_mv |
Gonzalez, Paula Natalia; Lotto, Federico Pablo; Hallgrimsson, Benedikt; Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 154; 4; 8-2014; 544-553 0002-9483 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.22545 info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22545/abstract |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-liss, Div John Wiley & Sons Inc |
publisher.none.fl_str_mv |
Wiley-liss, Div John Wiley & Sons Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614402908618752 |
score |
13.070432 |