Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
- Autores
- Fernandez, Luciana Andrea; Calderón, Marcelo; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; Gonzalez, Mercedes; Silber, Juana J.; Santo, Marisa Rosana
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug.
Fil: Fernandez, Luciana Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Calderón, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: Gonzalez, Mercedes. Universidad de la República; Uruguay
Fil: Silber, Juana J.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Santo, Marisa Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina - Materia
-
Dendrimers
Antichagasic Activity
Host-Guest Ineraction
Hemolysis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/29330
Ver los metadatos del registro completo
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Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compoundsFernandez, Luciana AndreaCalderón, MarceloMartinelli, MarisaStrumia, Miriam CristinaCerecetto, HugoGonzalez, MercedesSilber, Juana J.Santo, Marisa RosanaDendrimersAntichagasic ActivityHost-Guest IneractionHemolysishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug.Fil: Fernandez, Luciana Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Calderón, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Cerecetto, Hugo. Universidad de la República; UruguayFil: Gonzalez, Mercedes. Universidad de la República; UruguayFil: Silber, Juana J.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Santo, Marisa Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaJohn Wiley & Sons Ltd2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29330Fernandez, Luciana Andrea; Calderón, Marcelo ; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; et al.; Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds; John Wiley & Sons Ltd; Journal Of Physical Organic Chemistry; 21; 12; 12-2008; 1079-10850894-32301099-1395CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:40Zoai:ri.conicet.gov.ar:11336/29330instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:40.491CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
title |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
spellingShingle |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds Fernandez, Luciana Andrea Dendrimers Antichagasic Activity Host-Guest Ineraction Hemolysis |
title_short |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
title_full |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
title_fullStr |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
title_full_unstemmed |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
title_sort |
Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds |
dc.creator.none.fl_str_mv |
Fernandez, Luciana Andrea Calderón, Marcelo Martinelli, Marisa Strumia, Miriam Cristina Cerecetto, Hugo Gonzalez, Mercedes Silber, Juana J. Santo, Marisa Rosana |
author |
Fernandez, Luciana Andrea |
author_facet |
Fernandez, Luciana Andrea Calderón, Marcelo Martinelli, Marisa Strumia, Miriam Cristina Cerecetto, Hugo Gonzalez, Mercedes Silber, Juana J. Santo, Marisa Rosana |
author_role |
author |
author2 |
Calderón, Marcelo Martinelli, Marisa Strumia, Miriam Cristina Cerecetto, Hugo Gonzalez, Mercedes Silber, Juana J. Santo, Marisa Rosana |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Dendrimers Antichagasic Activity Host-Guest Ineraction Hemolysis |
topic |
Dendrimers Antichagasic Activity Host-Guest Ineraction Hemolysis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug. Fil: Fernandez, Luciana Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Calderón, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina Fil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Cerecetto, Hugo. Universidad de la República; Uruguay Fil: Gonzalez, Mercedes. Universidad de la República; Uruguay Fil: Silber, Juana J.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Santo, Marisa Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina |
description |
In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/29330 Fernandez, Luciana Andrea; Calderón, Marcelo ; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; et al.; Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds; John Wiley & Sons Ltd; Journal Of Physical Organic Chemistry; 21; 12; 12-2008; 1079-1085 0894-3230 1099-1395 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/29330 |
identifier_str_mv |
Fernandez, Luciana Andrea; Calderón, Marcelo ; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; et al.; Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds; John Wiley & Sons Ltd; Journal Of Physical Organic Chemistry; 21; 12; 12-2008; 1079-1085 0894-3230 1099-1395 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons Ltd |
publisher.none.fl_str_mv |
John Wiley & Sons Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613812734394368 |
score |
13.070432 |