Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds

Autores
Fernandez, Luciana Andrea; Calderón, Marcelo; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; Gonzalez, Mercedes; Silber, Juana J.; Santo, Marisa Rosana
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug.
Fil: Fernandez, Luciana Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Calderón, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: Gonzalez, Mercedes. Universidad de la República; Uruguay
Fil: Silber, Juana J.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Santo, Marisa Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Materia
Dendrimers
Antichagasic Activity
Host-Guest Ineraction
Hemolysis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29330
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/29330
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compoundsFernandez, Luciana AndreaCalderón, MarceloMartinelli, MarisaStrumia, Miriam CristinaCerecetto, HugoGonzalez, MercedesSilber, Juana J.Santo, Marisa RosanaDendrimersAntichagasic ActivityHost-Guest IneractionHemolysishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug.Fil: Fernandez, Luciana Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Calderón, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Cerecetto, Hugo. Universidad de la República; UruguayFil: Gonzalez, Mercedes. Universidad de la República; UruguayFil: Silber, Juana J.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Santo, Marisa Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaJohn Wiley & Sons Ltd2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29330Fernandez, Luciana Andrea; Calderón, Marcelo ; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; et al.; Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds; John Wiley & Sons Ltd; Journal Of Physical Organic Chemistry; 21; 12; 12-2008; 1079-10850894-32301099-1395CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:31:11Zoai:ri.conicet.gov.ar:11336/29330instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:31:11.242CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
title Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
spellingShingle Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
Fernandez, Luciana Andrea
Dendrimers
Antichagasic Activity
Host-Guest Ineraction
Hemolysis
title_short Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
title_full Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
title_fullStr Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
title_full_unstemmed Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
title_sort Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
dc.creator.none.fl_str_mv Fernandez, Luciana Andrea
Calderón, Marcelo
Martinelli, Marisa
Strumia, Miriam Cristina
Cerecetto, Hugo
Gonzalez, Mercedes
Silber, Juana J.
Santo, Marisa Rosana
author Fernandez, Luciana Andrea
author_facet Fernandez, Luciana Andrea
Calderón, Marcelo
Martinelli, Marisa
Strumia, Miriam Cristina
Cerecetto, Hugo
Gonzalez, Mercedes
Silber, Juana J.
Santo, Marisa Rosana
author_role author
author2 Calderón, Marcelo
Martinelli, Marisa
Strumia, Miriam Cristina
Cerecetto, Hugo
Gonzalez, Mercedes
Silber, Juana J.
Santo, Marisa Rosana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dendrimers
Antichagasic Activity
Host-Guest Ineraction
Hemolysis
topic Dendrimers
Antichagasic Activity
Host-Guest Ineraction
Hemolysis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug.
Fil: Fernandez, Luciana Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Calderón, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: Gonzalez, Mercedes. Universidad de la República; Uruguay
Fil: Silber, Juana J.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Santo, Marisa Rosana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
description In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′-(benzo[1,2-c] 1,2,5-oxadiazol-5(6)-yl (N-1-oxide) methylidene]-1-methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug.
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29330
Fernandez, Luciana Andrea; Calderón, Marcelo ; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; et al.; Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds; John Wiley & Sons Ltd; Journal Of Physical Organic Chemistry; 21; 12; 12-2008; 1079-1085
0894-3230
1099-1395
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29330
identifier_str_mv Fernandez, Luciana Andrea; Calderón, Marcelo ; Martinelli, Marisa; Strumia, Miriam Cristina; Cerecetto, Hugo; et al.; Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds; John Wiley & Sons Ltd; Journal Of Physical Organic Chemistry; 21; 12; 12-2008; 1079-1085
0894-3230
1099-1395
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781912619679744
score 12.928904

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