Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds

Autores
Peralta, Ignacio Nahuel; Cogoi, Laura Carolina; Filip, Rosana; Anesini, Claudia Alejandra
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The fresh leaves and stems of Ilex paraguariensis (Aquifoliaceae) are employed to prepare the commercial product used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named mate. The presence of polyphenols and xanthines, which present antioxidant activity, is well described in I. paraguariensis. ROS play an important role in tissue damage and pathological events in living organisms affecting erythrocyte?s membranes inducing to hemolysis. Taking into account, the aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green leaves) on the hemolysis of red blood cells (RBC) induced by H2O2 and correlate this activity with the enzymatic like activity related to H2O2 metabolism. The antioxidant activity of chlorogenic acid and caffeine was also analyzed in order to investigate their participation in the activity of the crude extract. The extract as well as the compounds protected RBC from hemolysis in relation to enzymatic CAT like activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of the great quantities of yerba mate consumed by population.
Fil: Peralta, Ignacio Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Cogoi, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Filip, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Anesini, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
Ilex paraguariensis
Caffeine
Antioxidant activity
Hemolysis protection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/273199
Acceder
id CONICETDig_584095dd43bf98bd205c35f474acf0c9
oai_identifier_str oai:ri.conicet.gov.ar:11336/273199
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine CompoundsPeralta, Ignacio NahuelCogoi, Laura CarolinaFilip, RosanaAnesini, Claudia AlejandraIlex paraguariensisCaffeineAntioxidant activityHemolysis protectionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The fresh leaves and stems of Ilex paraguariensis (Aquifoliaceae) are employed to prepare the commercial product used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named mate. The presence of polyphenols and xanthines, which present antioxidant activity, is well described in I. paraguariensis. ROS play an important role in tissue damage and pathological events in living organisms affecting erythrocyte?s membranes inducing to hemolysis. Taking into account, the aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green leaves) on the hemolysis of red blood cells (RBC) induced by H2O2 and correlate this activity with the enzymatic like activity related to H2O2 metabolism. The antioxidant activity of chlorogenic acid and caffeine was also analyzed in order to investigate their participation in the activity of the crude extract. The extract as well as the compounds protected RBC from hemolysis in relation to enzymatic CAT like activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of the great quantities of yerba mate consumed by population.Fil: Peralta, Ignacio Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Cogoi, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Filip, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Anesini, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaJohn Wiley & Sons Ltd2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/273199Peralta, Ignacio Nahuel; Cogoi, Laura Carolina; Filip, Rosana; Anesini, Claudia Alejandra; Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds; John Wiley & Sons Ltd; Phytotherapy Research; 27; 2; 4-2012; 192-1980951-418XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/ptr.4700info:eu-repo/semantics/altIdentifier/doi/10.1002/ptr.4700info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:51:33Zoai:ri.conicet.gov.ar:11336/273199instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:51:33.59CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
title Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
spellingShingle Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
Peralta, Ignacio Nahuel
Ilex paraguariensis
Caffeine
Antioxidant activity
Hemolysis protection
title_short Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
title_full Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
title_fullStr Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
title_full_unstemmed Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
title_sort Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds
dc.creator.none.fl_str_mv Peralta, Ignacio Nahuel
Cogoi, Laura Carolina
Filip, Rosana
Anesini, Claudia Alejandra
author Peralta, Ignacio Nahuel
author_facet Peralta, Ignacio Nahuel
Cogoi, Laura Carolina
Filip, Rosana
Anesini, Claudia Alejandra
author_role author
author2 Cogoi, Laura Carolina
Filip, Rosana
Anesini, Claudia Alejandra
author2_role author
author
author
dc.subject.none.fl_str_mv Ilex paraguariensis
Caffeine
Antioxidant activity
Hemolysis protection
topic Ilex paraguariensis
Caffeine
Antioxidant activity
Hemolysis protection
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The fresh leaves and stems of Ilex paraguariensis (Aquifoliaceae) are employed to prepare the commercial product used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named mate. The presence of polyphenols and xanthines, which present antioxidant activity, is well described in I. paraguariensis. ROS play an important role in tissue damage and pathological events in living organisms affecting erythrocyte?s membranes inducing to hemolysis. Taking into account, the aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green leaves) on the hemolysis of red blood cells (RBC) induced by H2O2 and correlate this activity with the enzymatic like activity related to H2O2 metabolism. The antioxidant activity of chlorogenic acid and caffeine was also analyzed in order to investigate their participation in the activity of the crude extract. The extract as well as the compounds protected RBC from hemolysis in relation to enzymatic CAT like activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of the great quantities of yerba mate consumed by population.
Fil: Peralta, Ignacio Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Cogoi, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Filip, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Anesini, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description The fresh leaves and stems of Ilex paraguariensis (Aquifoliaceae) are employed to prepare the commercial product used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named mate. The presence of polyphenols and xanthines, which present antioxidant activity, is well described in I. paraguariensis. ROS play an important role in tissue damage and pathological events in living organisms affecting erythrocyte?s membranes inducing to hemolysis. Taking into account, the aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green leaves) on the hemolysis of red blood cells (RBC) induced by H2O2 and correlate this activity with the enzymatic like activity related to H2O2 metabolism. The antioxidant activity of chlorogenic acid and caffeine was also analyzed in order to investigate their participation in the activity of the crude extract. The extract as well as the compounds protected RBC from hemolysis in relation to enzymatic CAT like activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of the great quantities of yerba mate consumed by population.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/273199
Peralta, Ignacio Nahuel; Cogoi, Laura Carolina; Filip, Rosana; Anesini, Claudia Alejandra; Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds; John Wiley & Sons Ltd; Phytotherapy Research; 27; 2; 4-2012; 192-198
0951-418X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/273199
identifier_str_mv Peralta, Ignacio Nahuel; Cogoi, Laura Carolina; Filip, Rosana; Anesini, Claudia Alejandra; Prevention of Hydrogen Peroxide‐Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds; John Wiley & Sons Ltd; Phytotherapy Research; 27; 2; 4-2012; 192-198
0951-418X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/ptr.4700
info:eu-repo/semantics/altIdentifier/doi/10.1002/ptr.4700
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083041928151040
score 13.22299

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