The modulation of liver methylome in liver diseases

Autores
Pirola, Carlos José; Sookoian, Silvia Cristina
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The importance of 5-Hydroxymethylcytosine (5-hmC) in the biology of non-cancerous human liver diseases, particularly nonalcoholic fatty liver disease (NAFLD), was recently described for the first time by our group [2]. We observed that nonnuclear-5-hmC, which is probably located in mitochondria, is lower in NAFLD as compared with controls. Therefore, 5-hmC may be involved in the modulation of the mitochondrial DNA methylome and gene expression, in particular components of the oxidative phosphorylation-chain, a finding that could explain much of the changes that occur during NAFLD disease progression, including fibrogenesis
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Epigenetics
Nafld
Methylation
Tet Proteins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38962
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The modulation of liver methylome in liver diseasesPirola, Carlos JoséSookoian, Silvia CristinaEpigeneticsNafldMethylationTet Proteinshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The importance of 5-Hydroxymethylcytosine (5-hmC) in the biology of non-cancerous human liver diseases, particularly nonalcoholic fatty liver disease (NAFLD), was recently described for the first time by our group [2]. We observed that nonnuclear-5-hmC, which is probably located in mitochondria, is lower in NAFLD as compared with controls. Therefore, 5-hmC may be involved in the modulation of the mitochondrial DNA methylome and gene expression, in particular components of the oxidative phosphorylation-chain, a finding that could explain much of the changes that occur during NAFLD disease progression, including fibrogenesisFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaElsevier Science2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38962Pirola, Carlos José; Sookoian, Silvia Cristina; The modulation of liver methylome in liver diseases; Elsevier Science; Journal of Hepatology; 64; 4; 4-2016; 987-9880168-8278CONICET DigitalCONICETengReferido a https://doi.org/10.1016/j.jhep.2015.11.024info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhep.2015.12.024info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168827816000167info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:40:29Zoai:ri.conicet.gov.ar:11336/38962instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:40:29.436CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The modulation of liver methylome in liver diseases
title The modulation of liver methylome in liver diseases
spellingShingle The modulation of liver methylome in liver diseases
Pirola, Carlos José
Epigenetics
Nafld
Methylation
Tet Proteins
title_short The modulation of liver methylome in liver diseases
title_full The modulation of liver methylome in liver diseases
title_fullStr The modulation of liver methylome in liver diseases
title_full_unstemmed The modulation of liver methylome in liver diseases
title_sort The modulation of liver methylome in liver diseases
dc.creator.none.fl_str_mv Pirola, Carlos José
Sookoian, Silvia Cristina
author Pirola, Carlos José
author_facet Pirola, Carlos José
Sookoian, Silvia Cristina
author_role author
author2 Sookoian, Silvia Cristina
author2_role author
dc.subject.none.fl_str_mv Epigenetics
Nafld
Methylation
Tet Proteins
topic Epigenetics
Nafld
Methylation
Tet Proteins
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The importance of 5-Hydroxymethylcytosine (5-hmC) in the biology of non-cancerous human liver diseases, particularly nonalcoholic fatty liver disease (NAFLD), was recently described for the first time by our group [2]. We observed that nonnuclear-5-hmC, which is probably located in mitochondria, is lower in NAFLD as compared with controls. Therefore, 5-hmC may be involved in the modulation of the mitochondrial DNA methylome and gene expression, in particular components of the oxidative phosphorylation-chain, a finding that could explain much of the changes that occur during NAFLD disease progression, including fibrogenesis
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description The importance of 5-Hydroxymethylcytosine (5-hmC) in the biology of non-cancerous human liver diseases, particularly nonalcoholic fatty liver disease (NAFLD), was recently described for the first time by our group [2]. We observed that nonnuclear-5-hmC, which is probably located in mitochondria, is lower in NAFLD as compared with controls. Therefore, 5-hmC may be involved in the modulation of the mitochondrial DNA methylome and gene expression, in particular components of the oxidative phosphorylation-chain, a finding that could explain much of the changes that occur during NAFLD disease progression, including fibrogenesis
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38962
Pirola, Carlos José; Sookoian, Silvia Cristina; The modulation of liver methylome in liver diseases; Elsevier Science; Journal of Hepatology; 64; 4; 4-2016; 987-988
0168-8278
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38962
identifier_str_mv Pirola, Carlos José; Sookoian, Silvia Cristina; The modulation of liver methylome in liver diseases; Elsevier Science; Journal of Hepatology; 64; 4; 4-2016; 987-988
0168-8278
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Referido a https://doi.org/10.1016/j.jhep.2015.11.024
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhep.2015.12.024
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168827816000167
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082896855564288
score 13.22299

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