Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice
- Autores
- Peng, Hongmei; Yang, Xiao Ping; Carretero, Oscar A.; Nakagawa, Pablo; D'Ambrosio, Martin; Leung, Pablo; Xu, Jiang; Peterson, Edward L.; González, Germán Esteban; Harding, Pamela; Rhaleb, Nour Eddine
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Balb/c mice, which are T-helper lymphocyte 2 (Th2) responders, are highly susceptible to infectious and non-infectious heart diseases, whereas C57BL/6 mice (Th1 responders) are not. Angiotensin II (Ang II) is not only a vasopressor but also a pro-inflammatory factor that leads to cardiac hypertrophy, fibrosis and dysfunction. We hypothesized that Ang II exacerbates cardiac damage in Balb/c but not in C57BL/6 mice even though both strains have a similar level of hypertension. Twelve-week-old male C57BL/6J and Balb/c mice received either vehicle or Ang II (1.4 mg kg -1 day -1, s.c. via osmotic minipump) for 8 weeks. At baseline, Balb/c mice exhibited the following: (1) a lower heart rate; (2) an enlarged left ventricular chamber; (3) a lower ejection fraction and shortening fraction; and (4) twice the left ventricular collagen deposition of age-matched C57BL/6J mice. Angiotensin II raised systolic blood pressure (to ~150 mmHg) and induced cardiomyocyte hypertrophy in a similar manner in both strains. While C57BL/6J mice developed compensatory concentric hypertrophy and fibrosis in response to Ang II, Balb/c mice demonstrated severe left ventricular chamber dilatation, wall thinning and fibrosis, leading to congestive heart failure as evidenced by dramatically decreased ejection fraction and lung congestion (significant increase in lung weight), which are both characteristic of dilated cardiomyopathy. Our study suggests that the Th phenotype plays an active role in cardiac remodelling and function both in basal conditions and in hypertension. Angiotensin II-induced dilated cardiomyopathy in Balb/c mice is an ideal animal model for studying the impact of the adaptive immune system on cardiac remodelling and function and for testing strategies to prevent or treat hypertension-associated heart failure. © 2011 The Authors. Journal compilation © 2011 The Physiological Society.
Fil: Peng, Hongmei. Henry Ford Hospital; Estados Unidos
Fil: Yang, Xiao Ping. Henry Ford Hospital; Estados Unidos
Fil: Carretero, Oscar A.. Henry Ford Hospital; Estados Unidos
Fil: Nakagawa, Pablo. Henry Ford Hospital; Estados Unidos
Fil: D'Ambrosio, Martin. Henry Ford Hospital; Estados Unidos
Fil: Leung, Pablo. Henry Ford Hospital; Estados Unidos
Fil: Xu, Jiang. Henry Ford Hospital; Estados Unidos
Fil: Peterson, Edward L.. Henry Ford Hospital; Estados Unidos
Fil: González, Germán Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Henry Ford Hospital; Estados Unidos
Fil: Harding, Pamela. Henry Ford Hospital; Estados Unidos
Fil: Rhaleb, Nour Eddine. Henry Ford Hospital; Estados Unidos - Materia
-
HYPERTENSION
ANGIOTENSIN II
IMMUNITY
VENTRICULAR FUNCTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/67545
Ver los metadatos del registro completo
id |
CONICETDig_8edd2e45ddecd6c640a28846eb6bc947 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/67545 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J micePeng, HongmeiYang, Xiao PingCarretero, Oscar A.Nakagawa, PabloD'Ambrosio, MartinLeung, PabloXu, JiangPeterson, Edward L.González, Germán EstebanHarding, PamelaRhaleb, Nour EddineHYPERTENSIONANGIOTENSIN IIIMMUNITYVENTRICULAR FUNCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Balb/c mice, which are T-helper lymphocyte 2 (Th2) responders, are highly susceptible to infectious and non-infectious heart diseases, whereas C57BL/6 mice (Th1 responders) are not. Angiotensin II (Ang II) is not only a vasopressor but also a pro-inflammatory factor that leads to cardiac hypertrophy, fibrosis and dysfunction. We hypothesized that Ang II exacerbates cardiac damage in Balb/c but not in C57BL/6 mice even though both strains have a similar level of hypertension. Twelve-week-old male C57BL/6J and Balb/c mice received either vehicle or Ang II (1.4 mg kg -1 day -1, s.c. via osmotic minipump) for 8 weeks. At baseline, Balb/c mice exhibited the following: (1) a lower heart rate; (2) an enlarged left ventricular chamber; (3) a lower ejection fraction and shortening fraction; and (4) twice the left ventricular collagen deposition of age-matched C57BL/6J mice. Angiotensin II raised systolic blood pressure (to ~150 mmHg) and induced cardiomyocyte hypertrophy in a similar manner in both strains. While C57BL/6J mice developed compensatory concentric hypertrophy and fibrosis in response to Ang II, Balb/c mice demonstrated severe left ventricular chamber dilatation, wall thinning and fibrosis, leading to congestive heart failure as evidenced by dramatically decreased ejection fraction and lung congestion (significant increase in lung weight), which are both characteristic of dilated cardiomyopathy. Our study suggests that the Th phenotype plays an active role in cardiac remodelling and function both in basal conditions and in hypertension. Angiotensin II-induced dilated cardiomyopathy in Balb/c mice is an ideal animal model for studying the impact of the adaptive immune system on cardiac remodelling and function and for testing strategies to prevent or treat hypertension-associated heart failure. © 2011 The Authors. Journal compilation © 2011 The Physiological Society.Fil: Peng, Hongmei. Henry Ford Hospital; Estados UnidosFil: Yang, Xiao Ping. Henry Ford Hospital; Estados UnidosFil: Carretero, Oscar A.. Henry Ford Hospital; Estados UnidosFil: Nakagawa, Pablo. Henry Ford Hospital; Estados UnidosFil: D'Ambrosio, Martin. Henry Ford Hospital; Estados UnidosFil: Leung, Pablo. Henry Ford Hospital; Estados UnidosFil: Xu, Jiang. Henry Ford Hospital; Estados UnidosFil: Peterson, Edward L.. Henry Ford Hospital; Estados UnidosFil: González, Germán Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Henry Ford Hospital; Estados UnidosFil: Harding, Pamela. Henry Ford Hospital; Estados UnidosFil: Rhaleb, Nour Eddine. Henry Ford Hospital; Estados UnidosWiley Blackwell Publishing, Inc2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/67545Peng, Hongmei; Yang, Xiao Ping; Carretero, Oscar A.; Nakagawa, Pablo; D'Ambrosio, Martin; et al.; Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice; Wiley Blackwell Publishing, Inc; Experimental Physiology; 96; 8; 8-2011; 756-7640958-0670CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1113/expphysiol.2011.057612info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2011.057612info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:11Zoai:ri.conicet.gov.ar:11336/67545instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:12.283CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
title |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
spellingShingle |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice Peng, Hongmei HYPERTENSION ANGIOTENSIN II IMMUNITY VENTRICULAR FUNCTION |
title_short |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
title_full |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
title_fullStr |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
title_full_unstemmed |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
title_sort |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice |
dc.creator.none.fl_str_mv |
Peng, Hongmei Yang, Xiao Ping Carretero, Oscar A. Nakagawa, Pablo D'Ambrosio, Martin Leung, Pablo Xu, Jiang Peterson, Edward L. González, Germán Esteban Harding, Pamela Rhaleb, Nour Eddine |
author |
Peng, Hongmei |
author_facet |
Peng, Hongmei Yang, Xiao Ping Carretero, Oscar A. Nakagawa, Pablo D'Ambrosio, Martin Leung, Pablo Xu, Jiang Peterson, Edward L. González, Germán Esteban Harding, Pamela Rhaleb, Nour Eddine |
author_role |
author |
author2 |
Yang, Xiao Ping Carretero, Oscar A. Nakagawa, Pablo D'Ambrosio, Martin Leung, Pablo Xu, Jiang Peterson, Edward L. González, Germán Esteban Harding, Pamela Rhaleb, Nour Eddine |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
HYPERTENSION ANGIOTENSIN II IMMUNITY VENTRICULAR FUNCTION |
topic |
HYPERTENSION ANGIOTENSIN II IMMUNITY VENTRICULAR FUNCTION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Balb/c mice, which are T-helper lymphocyte 2 (Th2) responders, are highly susceptible to infectious and non-infectious heart diseases, whereas C57BL/6 mice (Th1 responders) are not. Angiotensin II (Ang II) is not only a vasopressor but also a pro-inflammatory factor that leads to cardiac hypertrophy, fibrosis and dysfunction. We hypothesized that Ang II exacerbates cardiac damage in Balb/c but not in C57BL/6 mice even though both strains have a similar level of hypertension. Twelve-week-old male C57BL/6J and Balb/c mice received either vehicle or Ang II (1.4 mg kg -1 day -1, s.c. via osmotic minipump) for 8 weeks. At baseline, Balb/c mice exhibited the following: (1) a lower heart rate; (2) an enlarged left ventricular chamber; (3) a lower ejection fraction and shortening fraction; and (4) twice the left ventricular collagen deposition of age-matched C57BL/6J mice. Angiotensin II raised systolic blood pressure (to ~150 mmHg) and induced cardiomyocyte hypertrophy in a similar manner in both strains. While C57BL/6J mice developed compensatory concentric hypertrophy and fibrosis in response to Ang II, Balb/c mice demonstrated severe left ventricular chamber dilatation, wall thinning and fibrosis, leading to congestive heart failure as evidenced by dramatically decreased ejection fraction and lung congestion (significant increase in lung weight), which are both characteristic of dilated cardiomyopathy. Our study suggests that the Th phenotype plays an active role in cardiac remodelling and function both in basal conditions and in hypertension. Angiotensin II-induced dilated cardiomyopathy in Balb/c mice is an ideal animal model for studying the impact of the adaptive immune system on cardiac remodelling and function and for testing strategies to prevent or treat hypertension-associated heart failure. © 2011 The Authors. Journal compilation © 2011 The Physiological Society. Fil: Peng, Hongmei. Henry Ford Hospital; Estados Unidos Fil: Yang, Xiao Ping. Henry Ford Hospital; Estados Unidos Fil: Carretero, Oscar A.. Henry Ford Hospital; Estados Unidos Fil: Nakagawa, Pablo. Henry Ford Hospital; Estados Unidos Fil: D'Ambrosio, Martin. Henry Ford Hospital; Estados Unidos Fil: Leung, Pablo. Henry Ford Hospital; Estados Unidos Fil: Xu, Jiang. Henry Ford Hospital; Estados Unidos Fil: Peterson, Edward L.. Henry Ford Hospital; Estados Unidos Fil: González, Germán Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Henry Ford Hospital; Estados Unidos Fil: Harding, Pamela. Henry Ford Hospital; Estados Unidos Fil: Rhaleb, Nour Eddine. Henry Ford Hospital; Estados Unidos |
description |
Balb/c mice, which are T-helper lymphocyte 2 (Th2) responders, are highly susceptible to infectious and non-infectious heart diseases, whereas C57BL/6 mice (Th1 responders) are not. Angiotensin II (Ang II) is not only a vasopressor but also a pro-inflammatory factor that leads to cardiac hypertrophy, fibrosis and dysfunction. We hypothesized that Ang II exacerbates cardiac damage in Balb/c but not in C57BL/6 mice even though both strains have a similar level of hypertension. Twelve-week-old male C57BL/6J and Balb/c mice received either vehicle or Ang II (1.4 mg kg -1 day -1, s.c. via osmotic minipump) for 8 weeks. At baseline, Balb/c mice exhibited the following: (1) a lower heart rate; (2) an enlarged left ventricular chamber; (3) a lower ejection fraction and shortening fraction; and (4) twice the left ventricular collagen deposition of age-matched C57BL/6J mice. Angiotensin II raised systolic blood pressure (to ~150 mmHg) and induced cardiomyocyte hypertrophy in a similar manner in both strains. While C57BL/6J mice developed compensatory concentric hypertrophy and fibrosis in response to Ang II, Balb/c mice demonstrated severe left ventricular chamber dilatation, wall thinning and fibrosis, leading to congestive heart failure as evidenced by dramatically decreased ejection fraction and lung congestion (significant increase in lung weight), which are both characteristic of dilated cardiomyopathy. Our study suggests that the Th phenotype plays an active role in cardiac remodelling and function both in basal conditions and in hypertension. Angiotensin II-induced dilated cardiomyopathy in Balb/c mice is an ideal animal model for studying the impact of the adaptive immune system on cardiac remodelling and function and for testing strategies to prevent or treat hypertension-associated heart failure. © 2011 The Authors. Journal compilation © 2011 The Physiological Society. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/67545 Peng, Hongmei; Yang, Xiao Ping; Carretero, Oscar A.; Nakagawa, Pablo; D'Ambrosio, Martin; et al.; Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice; Wiley Blackwell Publishing, Inc; Experimental Physiology; 96; 8; 8-2011; 756-764 0958-0670 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/67545 |
identifier_str_mv |
Peng, Hongmei; Yang, Xiao Ping; Carretero, Oscar A.; Nakagawa, Pablo; D'Ambrosio, Martin; et al.; Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice; Wiley Blackwell Publishing, Inc; Experimental Physiology; 96; 8; 8-2011; 756-764 0958-0670 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1113/expphysiol.2011.057612 info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2011.057612 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/msword application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613133670285312 |
score |
13.070432 |