New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility

Autores
Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel; Vazquez, B.; Dalby, M.; Di Silvio, L.; San Roman, J.
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Acrylic bone cement formulations with antioxidant character were prepared by incorporation of a methacrylic monomer derived from vitamin E (MVE). Increasing concentrations of this monomer provided decreasing peak temperature values, ranging from 62 to 36°C, and increasing setting time with values between 17 and 25 min. Mechanical properties were evaluated by compression and tension tests. Compressive strength of the new formulations were superior to 70 MPa in all cases. The cement containing 25 wt % MVE, however, showed a significant decrease in tensile properties. Biocompatibility of the new formulations was studied in vitro. The analysis of the effect of leachables from cements into the media showed continued cell proliferation and cell viability with a significant increase for the cement containing 15 wt % MVE. This formulation also showed a significant increase in cellular proliferation over a period of 7 days as indicated by the Alamar Blue test. The cells were able to differentiate and express phenotypical markers in presence of all materials. A significant increase in alkaline phosphatase activity was observed on the cements prepared in presence of 15-25 wt % MVE compared with PMMA. Morphological assessment showed that the human osteoblast (HOB) cells were able to adhere, retain their morphology, and proliferate on all the cements. © 2002 Wiley Periodicals, Inc.
Fil: Mendez, J. A.. Consejo Superior de Investigaciones Científicas; España
Fil: Aguilar, M. R.. Consejo Superior de Investigaciones Científicas; España
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; España
Fil: Vazquez, B.. Consejo Superior de Investigaciones Científicas; España
Fil: Dalby, M.. IRC in Biomedical Materials; Reino Unido
Fil: Di Silvio, L.. IRC in Biomedical Materials; Reino Unido
Fil: San Roman, J.. Consejo Superior de Investigaciones Científicas; España
Materia
Acrylic Bone Cements
Biocompatibility
Biological Evaluation
In Vitro Testing
Vitamin e Derivative
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55121
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/55121
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibilityMendez, J. A.Aguilar, M. R.Abraham, Gustavo AbelVazquez, B.Dalby, M.Di Silvio, L.San Roman, J.Acrylic Bone CementsBiocompatibilityBiological EvaluationIn Vitro TestingVitamin e Derivativehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Acrylic bone cement formulations with antioxidant character were prepared by incorporation of a methacrylic monomer derived from vitamin E (MVE). Increasing concentrations of this monomer provided decreasing peak temperature values, ranging from 62 to 36°C, and increasing setting time with values between 17 and 25 min. Mechanical properties were evaluated by compression and tension tests. Compressive strength of the new formulations were superior to 70 MPa in all cases. The cement containing 25 wt % MVE, however, showed a significant decrease in tensile properties. Biocompatibility of the new formulations was studied in vitro. The analysis of the effect of leachables from cements into the media showed continued cell proliferation and cell viability with a significant increase for the cement containing 15 wt % MVE. This formulation also showed a significant increase in cellular proliferation over a period of 7 days as indicated by the Alamar Blue test. The cells were able to differentiate and express phenotypical markers in presence of all materials. A significant increase in alkaline phosphatase activity was observed on the cements prepared in presence of 15-25 wt % MVE compared with PMMA. Morphological assessment showed that the human osteoblast (HOB) cells were able to adhere, retain their morphology, and proliferate on all the cements. © 2002 Wiley Periodicals, Inc.Fil: Mendez, J. A.. Consejo Superior de Investigaciones Científicas; EspañaFil: Aguilar, M. R.. Consejo Superior de Investigaciones Científicas; EspañaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; EspañaFil: Vazquez, B.. Consejo Superior de Investigaciones Científicas; EspañaFil: Dalby, M.. IRC in Biomedical Materials; Reino UnidoFil: Di Silvio, L.. IRC in Biomedical Materials; Reino UnidoFil: San Roman, J.. Consejo Superior de Investigaciones Científicas; EspañaWiley2002-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55121Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel; Vazquez, B.; Dalby, M.; et al.; New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility; Wiley; Journal Of Biomedical Materials Research; 62; 2; 11-2002; 299-3070021-9304CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.10296info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.10296info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:57Zoai:ri.conicet.gov.ar:11336/55121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:57.746CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
title New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
spellingShingle New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
Mendez, J. A.
Acrylic Bone Cements
Biocompatibility
Biological Evaluation
In Vitro Testing
Vitamin e Derivative
title_short New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
title_full New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
title_fullStr New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
title_full_unstemmed New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
title_sort New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility
dc.creator.none.fl_str_mv Mendez, J. A.
Aguilar, M. R.
Abraham, Gustavo Abel
Vazquez, B.
Dalby, M.
Di Silvio, L.
San Roman, J.
author Mendez, J. A.
author_facet Mendez, J. A.
Aguilar, M. R.
Abraham, Gustavo Abel
Vazquez, B.
Dalby, M.
Di Silvio, L.
San Roman, J.
author_role author
author2 Aguilar, M. R.
Abraham, Gustavo Abel
Vazquez, B.
Dalby, M.
Di Silvio, L.
San Roman, J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Acrylic Bone Cements
Biocompatibility
Biological Evaluation
In Vitro Testing
Vitamin e Derivative
topic Acrylic Bone Cements
Biocompatibility
Biological Evaluation
In Vitro Testing
Vitamin e Derivative
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Acrylic bone cement formulations with antioxidant character were prepared by incorporation of a methacrylic monomer derived from vitamin E (MVE). Increasing concentrations of this monomer provided decreasing peak temperature values, ranging from 62 to 36°C, and increasing setting time with values between 17 and 25 min. Mechanical properties were evaluated by compression and tension tests. Compressive strength of the new formulations were superior to 70 MPa in all cases. The cement containing 25 wt % MVE, however, showed a significant decrease in tensile properties. Biocompatibility of the new formulations was studied in vitro. The analysis of the effect of leachables from cements into the media showed continued cell proliferation and cell viability with a significant increase for the cement containing 15 wt % MVE. This formulation also showed a significant increase in cellular proliferation over a period of 7 days as indicated by the Alamar Blue test. The cells were able to differentiate and express phenotypical markers in presence of all materials. A significant increase in alkaline phosphatase activity was observed on the cements prepared in presence of 15-25 wt % MVE compared with PMMA. Morphological assessment showed that the human osteoblast (HOB) cells were able to adhere, retain their morphology, and proliferate on all the cements. © 2002 Wiley Periodicals, Inc.
Fil: Mendez, J. A.. Consejo Superior de Investigaciones Científicas; España
Fil: Aguilar, M. R.. Consejo Superior de Investigaciones Científicas; España
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; España
Fil: Vazquez, B.. Consejo Superior de Investigaciones Científicas; España
Fil: Dalby, M.. IRC in Biomedical Materials; Reino Unido
Fil: Di Silvio, L.. IRC in Biomedical Materials; Reino Unido
Fil: San Roman, J.. Consejo Superior de Investigaciones Científicas; España
description Acrylic bone cement formulations with antioxidant character were prepared by incorporation of a methacrylic monomer derived from vitamin E (MVE). Increasing concentrations of this monomer provided decreasing peak temperature values, ranging from 62 to 36°C, and increasing setting time with values between 17 and 25 min. Mechanical properties were evaluated by compression and tension tests. Compressive strength of the new formulations were superior to 70 MPa in all cases. The cement containing 25 wt % MVE, however, showed a significant decrease in tensile properties. Biocompatibility of the new formulations was studied in vitro. The analysis of the effect of leachables from cements into the media showed continued cell proliferation and cell viability with a significant increase for the cement containing 15 wt % MVE. This formulation also showed a significant increase in cellular proliferation over a period of 7 days as indicated by the Alamar Blue test. The cells were able to differentiate and express phenotypical markers in presence of all materials. A significant increase in alkaline phosphatase activity was observed on the cements prepared in presence of 15-25 wt % MVE compared with PMMA. Morphological assessment showed that the human osteoblast (HOB) cells were able to adhere, retain their morphology, and proliferate on all the cements. © 2002 Wiley Periodicals, Inc.
publishDate 2002
dc.date.none.fl_str_mv 2002-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55121
Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel; Vazquez, B.; Dalby, M.; et al.; New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility; Wiley; Journal Of Biomedical Materials Research; 62; 2; 11-2002; 299-307
0021-9304
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55121
identifier_str_mv Mendez, J. A.; Aguilar, M. R.; Abraham, Gustavo Abel; Vazquez, B.; Dalby, M.; et al.; New acrylic bone cements conjugated to vitamin E: Curing parameters, properties, and biocompatibility; Wiley; Journal Of Biomedical Materials Research; 62; 2; 11-2002; 299-307
0021-9304
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.10296
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.10296
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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