Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome pr...

Autores
Ferreira, M. R.; Chicco, Adriana Graciela; Lombardo, Y. B.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study evaluates some possible mechanisms behind the beneficial effects of dietary fish oil (FO) on β cell dysfunction in rats fed a sucrose-rich diet (SRD). Rats were fed a SRD for 6 months. Thereafter, half the rats received a SRD in which corn oil was partially replaced by FO up to 8 months. The other half continued consuming the SRD up to 8 months. A control group was fed a control diet throughout the experimental period. In isolated islets of SRD-fed rats dietary FO normalized the reduced glucose phosphorylation, the altered glucose oxidation, the triglyceride content, the increased protein mass levels of peroxisome proliferator-activated receptor γ (PPARγ) and uncoupling protein 2 without changes in GLUT2 and PPARα. These finding suggest that the changes mentioned above could be involved in the normalization of the altered glucose-stimulated insulin secretion pattern in this nutritional model of dyslipidemia and insulin resistance.
Fil: Ferreira, M. R.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Lombardo, Y. B.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
Materia
Aceite de Pescado
Dislipidemia
Secrecion De Insulina Inducida por Glucosa
Ucp2 Ppars
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6412
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6412
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2Ferreira, M. R.Chicco, Adriana GracielaLombardo, Y. B.Aceite de PescadoDislipidemiaSecrecion De Insulina Inducida por GlucosaUcp2 Pparshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This study evaluates some possible mechanisms behind the beneficial effects of dietary fish oil (FO) on β cell dysfunction in rats fed a sucrose-rich diet (SRD). Rats were fed a SRD for 6 months. Thereafter, half the rats received a SRD in which corn oil was partially replaced by FO up to 8 months. The other half continued consuming the SRD up to 8 months. A control group was fed a control diet throughout the experimental period. In isolated islets of SRD-fed rats dietary FO normalized the reduced glucose phosphorylation, the altered glucose oxidation, the triglyceride content, the increased protein mass levels of peroxisome proliferator-activated receptor γ (PPARγ) and uncoupling protein 2 without changes in GLUT2 and PPARα. These finding suggest that the changes mentioned above could be involved in the normalization of the altered glucose-stimulated insulin secretion pattern in this nutritional model of dyslipidemia and insulin resistance.Fil: Ferreira, M. R.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; ArgentinaFil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Lombardo, Y. B.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; ArgentinaElsevier2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6412Ferreira, M. R.; Chicco, Adriana Graciela; Lombardo, Y. B.; Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2; Elsevier; Prostaglandins Leukotrienes And Essential Fatty Acids; 89; 1; 5-2013; 31-380952-3278enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327813000963info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2013.04.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:52:56Zoai:ri.conicet.gov.ar:11336/6412instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:52:57.021CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
title Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
spellingShingle Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
Ferreira, M. R.
Aceite de Pescado
Dislipidemia
Secrecion De Insulina Inducida por Glucosa
Ucp2 Ppars
title_short Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
title_full Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
title_fullStr Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
title_full_unstemmed Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
title_sort Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
dc.creator.none.fl_str_mv Ferreira, M. R.
Chicco, Adriana Graciela
Lombardo, Y. B.
author Ferreira, M. R.
author_facet Ferreira, M. R.
Chicco, Adriana Graciela
Lombardo, Y. B.
author_role author
author2 Chicco, Adriana Graciela
Lombardo, Y. B.
author2_role author
author
dc.subject.none.fl_str_mv Aceite de Pescado
Dislipidemia
Secrecion De Insulina Inducida por Glucosa
Ucp2 Ppars
topic Aceite de Pescado
Dislipidemia
Secrecion De Insulina Inducida por Glucosa
Ucp2 Ppars
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study evaluates some possible mechanisms behind the beneficial effects of dietary fish oil (FO) on β cell dysfunction in rats fed a sucrose-rich diet (SRD). Rats were fed a SRD for 6 months. Thereafter, half the rats received a SRD in which corn oil was partially replaced by FO up to 8 months. The other half continued consuming the SRD up to 8 months. A control group was fed a control diet throughout the experimental period. In isolated islets of SRD-fed rats dietary FO normalized the reduced glucose phosphorylation, the altered glucose oxidation, the triglyceride content, the increased protein mass levels of peroxisome proliferator-activated receptor γ (PPARγ) and uncoupling protein 2 without changes in GLUT2 and PPARα. These finding suggest that the changes mentioned above could be involved in the normalization of the altered glucose-stimulated insulin secretion pattern in this nutritional model of dyslipidemia and insulin resistance.
Fil: Ferreira, M. R.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Lombardo, Y. B.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
description This study evaluates some possible mechanisms behind the beneficial effects of dietary fish oil (FO) on β cell dysfunction in rats fed a sucrose-rich diet (SRD). Rats were fed a SRD for 6 months. Thereafter, half the rats received a SRD in which corn oil was partially replaced by FO up to 8 months. The other half continued consuming the SRD up to 8 months. A control group was fed a control diet throughout the experimental period. In isolated islets of SRD-fed rats dietary FO normalized the reduced glucose phosphorylation, the altered glucose oxidation, the triglyceride content, the increased protein mass levels of peroxisome proliferator-activated receptor γ (PPARγ) and uncoupling protein 2 without changes in GLUT2 and PPARα. These finding suggest that the changes mentioned above could be involved in the normalization of the altered glucose-stimulated insulin secretion pattern in this nutritional model of dyslipidemia and insulin resistance.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6412
Ferreira, M. R.; Chicco, Adriana Graciela; Lombardo, Y. B.; Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2; Elsevier; Prostaglandins Leukotrienes And Essential Fatty Acids; 89; 1; 5-2013; 31-38
0952-3278
url http://hdl.handle.net/11336/6412
identifier_str_mv Ferreira, M. R.; Chicco, Adriana Graciela; Lombardo, Y. B.; Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2; Elsevier; Prostaglandins Leukotrienes And Essential Fatty Acids; 89; 1; 5-2013; 31-38
0952-3278
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327813000963
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2013.04.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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