Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications

Autores
Lopez, Guillermo Pablo; Barberia Roque, Leyanet; Igal, Katerine; Gámez Espinosa, Erasmo Junior; Bellotti, Natalia
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: New bioactive hybrid materials to prevent biofilm-induced biodeterioration are a significant challenge in indoor environments, where contaminants from microbial films compromise structural integrity and contribute to air pollution, posing health risks from prolonged exposure to biological agents. Methods: For the first time, diatomaceous earth or diatomite (Dt) was functionalized with quaternary ammonium salt (QAS) and a biogenic compound, citronellol, to develop a bioactive hybrid material (Dt*QC). The hybrids obtained were characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR). The antifungal and antibacterial activity were assessed by agar diffusion assay, and micro/macrodilution tests. Results and Discussion: Characterization confirmed successful functionalization. TGA revealed organic contents of 50.9% with citronellol incorporation reaching 48.1%. SEM-EDS corroborated the incorporation of organic components. FTIR further verified the integration of functional groups while preserving the structural stability of the siliceous framework. Antimicrobial assays revealed a broader range of activity for Dt*QC. For bacterial strains, Dt*QC achieved a minimum inhibitory concentration (MIC) of 0.15 mg/mL against Staphylococcus aureus and demonstrated over 99.9% bacterial reduction, even at lower concentrations. This study highlights a novel approach to developing antimicrobial materials by functionalizing Dt with QAS and citronellol. Overall, these findings underscore the potential of Dt*QC as an advanced antimicrobial material for applications in coatings and preservation systems, offering a sustainable solution to prevent biodeterioration and microbial contamination.
Fil: Lopez, Guillermo Pablo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Barberia Roque, Leyanet. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Igal, Katerine. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Gámez Espinosa, Erasmo Junior. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Bellotti, Natalia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Materia
diatomaceous earth
citronellol
functionalization
bioactive hybrids
terpenoid
antifungal
antibacterial
biocide
functionalization
bioactive hybrids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/264971
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/264971
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applicationsLopez, Guillermo PabloBarberia Roque, LeyanetIgal, KaterineGámez Espinosa, Erasmo JuniorBellotti, Nataliadiatomaceous earthcitronellolfunctionalizationbioactive hybridsterpenoidantifungalantibacterialbiocidefunctionalizationbioactive hybridshttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Introduction: New bioactive hybrid materials to prevent biofilm-induced biodeterioration are a significant challenge in indoor environments, where contaminants from microbial films compromise structural integrity and contribute to air pollution, posing health risks from prolonged exposure to biological agents. Methods: For the first time, diatomaceous earth or diatomite (Dt) was functionalized with quaternary ammonium salt (QAS) and a biogenic compound, citronellol, to develop a bioactive hybrid material (Dt*QC). The hybrids obtained were characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR). The antifungal and antibacterial activity were assessed by agar diffusion assay, and micro/macrodilution tests. Results and Discussion: Characterization confirmed successful functionalization. TGA revealed organic contents of 50.9% with citronellol incorporation reaching 48.1%. SEM-EDS corroborated the incorporation of organic components. FTIR further verified the integration of functional groups while preserving the structural stability of the siliceous framework. Antimicrobial assays revealed a broader range of activity for Dt*QC. For bacterial strains, Dt*QC achieved a minimum inhibitory concentration (MIC) of 0.15 mg/mL against Staphylococcus aureus and demonstrated over 99.9% bacterial reduction, even at lower concentrations. This study highlights a novel approach to developing antimicrobial materials by functionalizing Dt with QAS and citronellol. Overall, these findings underscore the potential of Dt*QC as an advanced antimicrobial material for applications in coatings and preservation systems, offering a sustainable solution to prevent biodeterioration and microbial contamination.Fil: Lopez, Guillermo Pablo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Barberia Roque, Leyanet. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Igal, Katerine. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Gámez Espinosa, Erasmo Junior. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Bellotti, Natalia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFrontiers Media2025-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/264971Lopez, Guillermo Pablo; Barberia Roque, Leyanet; Igal, Katerine; Gámez Espinosa, Erasmo Junior; Bellotti, Natalia; Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications; Frontiers Media; Frontiers in Chemistry; 13; 1-2025; 1-122296-2646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fchem.2025.1535787/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fchem.2025.1535787info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:23:52Zoai:ri.conicet.gov.ar:11336/264971instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:23:53.208CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
title Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
spellingShingle Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
Lopez, Guillermo Pablo
diatomaceous earth
citronellol
functionalization
bioactive hybrids
terpenoid
antifungal
antibacterial
biocide
functionalization
bioactive hybrids
title_short Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
title_full Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
title_fullStr Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
title_full_unstemmed Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
title_sort Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications
dc.creator.none.fl_str_mv Lopez, Guillermo Pablo
Barberia Roque, Leyanet
Igal, Katerine
Gámez Espinosa, Erasmo Junior
Bellotti, Natalia
author Lopez, Guillermo Pablo
author_facet Lopez, Guillermo Pablo
Barberia Roque, Leyanet
Igal, Katerine
Gámez Espinosa, Erasmo Junior
Bellotti, Natalia
author_role author
author2 Barberia Roque, Leyanet
Igal, Katerine
Gámez Espinosa, Erasmo Junior
Bellotti, Natalia
author2_role author
author
author
author
dc.subject.none.fl_str_mv diatomaceous earth
citronellol
functionalization
bioactive hybrids
terpenoid
antifungal
antibacterial
biocide
functionalization
bioactive hybrids
topic diatomaceous earth
citronellol
functionalization
bioactive hybrids
terpenoid
antifungal
antibacterial
biocide
functionalization
bioactive hybrids
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Introduction: New bioactive hybrid materials to prevent biofilm-induced biodeterioration are a significant challenge in indoor environments, where contaminants from microbial films compromise structural integrity and contribute to air pollution, posing health risks from prolonged exposure to biological agents. Methods: For the first time, diatomaceous earth or diatomite (Dt) was functionalized with quaternary ammonium salt (QAS) and a biogenic compound, citronellol, to develop a bioactive hybrid material (Dt*QC). The hybrids obtained were characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR). The antifungal and antibacterial activity were assessed by agar diffusion assay, and micro/macrodilution tests. Results and Discussion: Characterization confirmed successful functionalization. TGA revealed organic contents of 50.9% with citronellol incorporation reaching 48.1%. SEM-EDS corroborated the incorporation of organic components. FTIR further verified the integration of functional groups while preserving the structural stability of the siliceous framework. Antimicrobial assays revealed a broader range of activity for Dt*QC. For bacterial strains, Dt*QC achieved a minimum inhibitory concentration (MIC) of 0.15 mg/mL against Staphylococcus aureus and demonstrated over 99.9% bacterial reduction, even at lower concentrations. This study highlights a novel approach to developing antimicrobial materials by functionalizing Dt with QAS and citronellol. Overall, these findings underscore the potential of Dt*QC as an advanced antimicrobial material for applications in coatings and preservation systems, offering a sustainable solution to prevent biodeterioration and microbial contamination.
Fil: Lopez, Guillermo Pablo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Barberia Roque, Leyanet. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Igal, Katerine. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Gámez Espinosa, Erasmo Junior. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Bellotti, Natalia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
description Introduction: New bioactive hybrid materials to prevent biofilm-induced biodeterioration are a significant challenge in indoor environments, where contaminants from microbial films compromise structural integrity and contribute to air pollution, posing health risks from prolonged exposure to biological agents. Methods: For the first time, diatomaceous earth or diatomite (Dt) was functionalized with quaternary ammonium salt (QAS) and a biogenic compound, citronellol, to develop a bioactive hybrid material (Dt*QC). The hybrids obtained were characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR). The antifungal and antibacterial activity were assessed by agar diffusion assay, and micro/macrodilution tests. Results and Discussion: Characterization confirmed successful functionalization. TGA revealed organic contents of 50.9% with citronellol incorporation reaching 48.1%. SEM-EDS corroborated the incorporation of organic components. FTIR further verified the integration of functional groups while preserving the structural stability of the siliceous framework. Antimicrobial assays revealed a broader range of activity for Dt*QC. For bacterial strains, Dt*QC achieved a minimum inhibitory concentration (MIC) of 0.15 mg/mL against Staphylococcus aureus and demonstrated over 99.9% bacterial reduction, even at lower concentrations. This study highlights a novel approach to developing antimicrobial materials by functionalizing Dt with QAS and citronellol. Overall, these findings underscore the potential of Dt*QC as an advanced antimicrobial material for applications in coatings and preservation systems, offering a sustainable solution to prevent biodeterioration and microbial contamination.
publishDate 2025
dc.date.none.fl_str_mv 2025-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/264971
Lopez, Guillermo Pablo; Barberia Roque, Leyanet; Igal, Katerine; Gámez Espinosa, Erasmo Junior; Bellotti, Natalia; Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications; Frontiers Media; Frontiers in Chemistry; 13; 1-2025; 1-12
2296-2646
CONICET Digital
CONICET
url http://hdl.handle.net/11336/264971
identifier_str_mv Lopez, Guillermo Pablo; Barberia Roque, Leyanet; Igal, Katerine; Gámez Espinosa, Erasmo Junior; Bellotti, Natalia; Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications; Frontiers Media; Frontiers in Chemistry; 13; 1-2025; 1-12
2296-2646
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fchem.2025.1535787/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fchem.2025.1535787
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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