Follicular helper T lymphocytes in health and disease

Autores
Parodi Ramoneda, Cecilia María; Badano, Maria Noel; Galassi, Nora Virginia; Coraglia, Ana Carina; Baré, Patricia; Malbrán, Alejandro; de Elizalde, Maria Marta
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes (TFH) in this reaction. We shall focus on the regulation of their development and function in health and disease. TFH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper IgM syndrome or X-linked lymphoproliferative disease. Increased numbers of TFH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating TFH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of TFH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.
Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Badano, Maria Noel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Coraglia, Ana Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Malbrán, Alejandro. Unidad de Alergía, Asma e Inmunología Clínica; Argentina
Fil: de Elizalde, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Materia
Follicular T Lymphocytes
Immunodeficiences
Viral Diseases
Parasitic Diseases
Autoimmunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42749
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/42749
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Follicular helper T lymphocytes in health and diseaseParodi Ramoneda, Cecilia MaríaBadano, Maria NoelGalassi, Nora VirginiaCoraglia, Ana CarinaBaré, PatriciaMalbrán, Alejandrode Elizalde, Maria MartaFollicular T LymphocytesImmunodeficiencesViral DiseasesParasitic DiseasesAutoimmunityhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes (TFH) in this reaction. We shall focus on the regulation of their development and function in health and disease. TFH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper IgM syndrome or X-linked lymphoproliferative disease. Increased numbers of TFH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating TFH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of TFH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Badano, Maria Noel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Coraglia, Ana Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Malbrán, Alejandro. Unidad de Alergía, Asma e Inmunología Clínica; ArgentinaFil: de Elizalde, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaBaishideng Publishing Group2014-11-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42749Parodi Ramoneda, Cecilia María; Badano, Maria Noel; Galassi, Nora Virginia; Coraglia, Ana Carina; Baré, Patricia; et al.; Follicular helper T lymphocytes in health and disease; Baishideng Publishing Group; World Journal of Hematology; 3; 4; 6-11-2014; 118-1272218-6204CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.5315/wjh.v3.i4.118info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2218-6204/abstract/v3/i4/118.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:38Zoai:ri.conicet.gov.ar:11336/42749instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:38.667CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Follicular helper T lymphocytes in health and disease
title Follicular helper T lymphocytes in health and disease
spellingShingle Follicular helper T lymphocytes in health and disease
Parodi Ramoneda, Cecilia María
Follicular T Lymphocytes
Immunodeficiences
Viral Diseases
Parasitic Diseases
Autoimmunity
title_short Follicular helper T lymphocytes in health and disease
title_full Follicular helper T lymphocytes in health and disease
title_fullStr Follicular helper T lymphocytes in health and disease
title_full_unstemmed Follicular helper T lymphocytes in health and disease
title_sort Follicular helper T lymphocytes in health and disease
dc.creator.none.fl_str_mv Parodi Ramoneda, Cecilia María
Badano, Maria Noel
Galassi, Nora Virginia
Coraglia, Ana Carina
Baré, Patricia
Malbrán, Alejandro
de Elizalde, Maria Marta
author Parodi Ramoneda, Cecilia María
author_facet Parodi Ramoneda, Cecilia María
Badano, Maria Noel
Galassi, Nora Virginia
Coraglia, Ana Carina
Baré, Patricia
Malbrán, Alejandro
de Elizalde, Maria Marta
author_role author
author2 Badano, Maria Noel
Galassi, Nora Virginia
Coraglia, Ana Carina
Baré, Patricia
Malbrán, Alejandro
de Elizalde, Maria Marta
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Follicular T Lymphocytes
Immunodeficiences
Viral Diseases
Parasitic Diseases
Autoimmunity
topic Follicular T Lymphocytes
Immunodeficiences
Viral Diseases
Parasitic Diseases
Autoimmunity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes (TFH) in this reaction. We shall focus on the regulation of their development and function in health and disease. TFH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper IgM syndrome or X-linked lymphoproliferative disease. Increased numbers of TFH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating TFH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of TFH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.
Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Badano, Maria Noel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Coraglia, Ana Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Malbrán, Alejandro. Unidad de Alergía, Asma e Inmunología Clínica; Argentina
Fil: de Elizalde, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
description A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes (TFH) in this reaction. We shall focus on the regulation of their development and function in health and disease. TFH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper IgM syndrome or X-linked lymphoproliferative disease. Increased numbers of TFH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating TFH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of TFH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42749
Parodi Ramoneda, Cecilia María; Badano, Maria Noel; Galassi, Nora Virginia; Coraglia, Ana Carina; Baré, Patricia; et al.; Follicular helper T lymphocytes in health and disease; Baishideng Publishing Group; World Journal of Hematology; 3; 4; 6-11-2014; 118-127
2218-6204
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42749
identifier_str_mv Parodi Ramoneda, Cecilia María; Badano, Maria Noel; Galassi, Nora Virginia; Coraglia, Ana Carina; Baré, Patricia; et al.; Follicular helper T lymphocytes in health and disease; Baishideng Publishing Group; World Journal of Hematology; 3; 4; 6-11-2014; 118-127
2218-6204
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.5315/wjh.v3.i4.118
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/2218-6204/abstract/v3/i4/118.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270010322452480
score 13.13397

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