The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus

Autores
Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.
Fil: Cuneo, Javier I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Quiroz, Nicolas H.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Weisz, Victoria I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Argibay, Pablo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Computational neuroscience
Neurogenesis
Hippocampus
Modelling
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/197790
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/197790
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling The computational influence of neurogenesis in the processing of spatial information in the dentate gyrusCuneo, Javier I.Quiroz, Nicolas H.Weisz, Victoria I.Argibay, PabloComputational neuroscienceNeurogenesisHippocampusModellinghttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.Fil: Cuneo, Javier I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Quiroz, Nicolas H.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Weisz, Victoria I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Argibay, Pablo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaNature2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/197790Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo; The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus; Nature; Scientific Reports; 2; 10-2012; 1-62045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep00735info:eu-repo/semantics/altIdentifier/doi/10.1038/srep00735info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:46Zoai:ri.conicet.gov.ar:11336/197790instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:46.337CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
title The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
spellingShingle The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
Cuneo, Javier I.
Computational neuroscience
Neurogenesis
Hippocampus
Modelling
title_short The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
title_full The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
title_fullStr The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
title_full_unstemmed The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
title_sort The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
dc.creator.none.fl_str_mv Cuneo, Javier I.
Quiroz, Nicolas H.
Weisz, Victoria I.
Argibay, Pablo
author Cuneo, Javier I.
author_facet Cuneo, Javier I.
Quiroz, Nicolas H.
Weisz, Victoria I.
Argibay, Pablo
author_role author
author2 Quiroz, Nicolas H.
Weisz, Victoria I.
Argibay, Pablo
author2_role author
author
author
dc.subject.none.fl_str_mv Computational neuroscience
Neurogenesis
Hippocampus
Modelling
topic Computational neuroscience
Neurogenesis
Hippocampus
Modelling
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.
Fil: Cuneo, Javier I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Quiroz, Nicolas H.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Weisz, Victoria I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Argibay, Pablo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/197790
Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo; The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus; Nature; Scientific Reports; 2; 10-2012; 1-6
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/197790
identifier_str_mv Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo; The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus; Nature; Scientific Reports; 2; 10-2012; 1-6
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep00735
info:eu-repo/semantics/altIdentifier/doi/10.1038/srep00735
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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