The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus
- Autores
- Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.
Fil: Cuneo, Javier I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Quiroz, Nicolas H.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Weisz, Victoria I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Argibay, Pablo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Computational neuroscience
Neurogenesis
Hippocampus
Modelling - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/197790
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/197790 |
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CONICET Digital (CONICET) |
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The computational influence of neurogenesis in the processing of spatial information in the dentate gyrusCuneo, Javier I.Quiroz, Nicolas H.Weisz, Victoria I.Argibay, PabloComputational neuroscienceNeurogenesisHippocampusModellinghttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.Fil: Cuneo, Javier I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Quiroz, Nicolas H.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Weisz, Victoria I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Argibay, Pablo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaNature2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/197790Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo; The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus; Nature; Scientific Reports; 2; 10-2012; 1-62045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep00735info:eu-repo/semantics/altIdentifier/doi/10.1038/srep00735info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:39Zoai:ri.conicet.gov.ar:11336/197790instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:40.139CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
title |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
spellingShingle |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus Cuneo, Javier I. Computational neuroscience Neurogenesis Hippocampus Modelling |
title_short |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
title_full |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
title_fullStr |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
title_full_unstemmed |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
title_sort |
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus |
dc.creator.none.fl_str_mv |
Cuneo, Javier I. Quiroz, Nicolas H. Weisz, Victoria I. Argibay, Pablo |
author |
Cuneo, Javier I. |
author_facet |
Cuneo, Javier I. Quiroz, Nicolas H. Weisz, Victoria I. Argibay, Pablo |
author_role |
author |
author2 |
Quiroz, Nicolas H. Weisz, Victoria I. Argibay, Pablo |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Computational neuroscience Neurogenesis Hippocampus Modelling |
topic |
Computational neuroscience Neurogenesis Hippocampus Modelling |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.2 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells. Fil: Cuneo, Javier I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina Fil: Quiroz, Nicolas H.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina Fil: Weisz, Victoria I.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina Fil: Argibay, Pablo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/197790 Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo; The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus; Nature; Scientific Reports; 2; 10-2012; 1-6 2045-2322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/197790 |
identifier_str_mv |
Cuneo, Javier I.; Quiroz, Nicolas H.; Weisz, Victoria I.; Argibay, Pablo; The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus; Nature; Scientific Reports; 2; 10-2012; 1-6 2045-2322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep00735 info:eu-repo/semantics/altIdentifier/doi/10.1038/srep00735 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature |
publisher.none.fl_str_mv |
Nature |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268986499137536 |
score |
13.13397 |