Human platelets and their capacity of binding viruses: Meaning and challenges?

Autores
Chabert, Adrien; Hamzeh Cognasse, Hind; Pozzetto, Bruno; Cognasse, Fabrice; Schattner, Mirta Ana; Gomez, Ricardo Martin; Garraud, Olivier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infectious ones. Platelets express pathogen recognition receptors that can sense bacterial and viral moieties. Besides, several molecules that bind epithelial or sub-endothelial molecules and, so forth, are involved in hemostasis, happen to be able to ligate viral determinants, making platelets capable of either binding viruses or even to be infected by some of them. Further, as platelets express both Fc-receptors for Ig and complement receptors, they also bind occasionally virus-Ig or virus-Ig-complement immune complexes. Interplays of viruses with platelets are very complex and viral infections often interfere with platelet number and functions. Through a few instances of viral infections, the present review aims at presenting some of the most important interactions from pathophysiological and clinical points of view, which are observed between human viruses and platelets.
Fil: Chabert, Adrien. Universite Lyon 2; Francia
Fil: Hamzeh Cognasse, Hind. Universite Lyon 2; Francia
Fil: Pozzetto, Bruno. Universite Lyon 2; Francia
Fil: Cognasse, Fabrice. Universite Lyon 2; Francia
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Garraud, Olivier. Universite Lyon 2; Francia
Materia
HEMOSTASIS
INFECTION
PLATELETS
RECEPTORS
VIRUSES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38423
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Human platelets and their capacity of binding viruses: Meaning and challenges?Chabert, AdrienHamzeh Cognasse, HindPozzetto, BrunoCognasse, FabriceSchattner, Mirta AnaGomez, Ricardo MartinGarraud, OlivierHEMOSTASISINFECTIONPLATELETSRECEPTORSVIRUSEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infectious ones. Platelets express pathogen recognition receptors that can sense bacterial and viral moieties. Besides, several molecules that bind epithelial or sub-endothelial molecules and, so forth, are involved in hemostasis, happen to be able to ligate viral determinants, making platelets capable of either binding viruses or even to be infected by some of them. Further, as platelets express both Fc-receptors for Ig and complement receptors, they also bind occasionally virus-Ig or virus-Ig-complement immune complexes. Interplays of viruses with platelets are very complex and viral infections often interfere with platelet number and functions. Through a few instances of viral infections, the present review aims at presenting some of the most important interactions from pathophysiological and clinical points of view, which are observed between human viruses and platelets.Fil: Chabert, Adrien. Universite Lyon 2; FranciaFil: Hamzeh Cognasse, Hind. Universite Lyon 2; FranciaFil: Pozzetto, Bruno. Universite Lyon 2; FranciaFil: Cognasse, Fabrice. Universite Lyon 2; FranciaFil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Garraud, Olivier. Universite Lyon 2; FranciaBioMed Central2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38423Chabert, Adrien; Hamzeh Cognasse, Hind; Pozzetto, Bruno; Cognasse, Fabrice; Schattner, Mirta Ana; et al.; Human platelets and their capacity of binding viruses: Meaning and challenges?; BioMed Central; BMC Immunology; 16; 1; 4-2015; 1-81471-2172CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12865-015-0092-1info:eu-repo/semantics/altIdentifier/url/https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-015-0092-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:46Zoai:ri.conicet.gov.ar:11336/38423instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:46.611CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human platelets and their capacity of binding viruses: Meaning and challenges?
title Human platelets and their capacity of binding viruses: Meaning and challenges?
spellingShingle Human platelets and their capacity of binding viruses: Meaning and challenges?
Chabert, Adrien
HEMOSTASIS
INFECTION
PLATELETS
RECEPTORS
VIRUSES
title_short Human platelets and their capacity of binding viruses: Meaning and challenges?
title_full Human platelets and their capacity of binding viruses: Meaning and challenges?
title_fullStr Human platelets and their capacity of binding viruses: Meaning and challenges?
title_full_unstemmed Human platelets and their capacity of binding viruses: Meaning and challenges?
title_sort Human platelets and their capacity of binding viruses: Meaning and challenges?
dc.creator.none.fl_str_mv Chabert, Adrien
Hamzeh Cognasse, Hind
Pozzetto, Bruno
Cognasse, Fabrice
Schattner, Mirta Ana
Gomez, Ricardo Martin
Garraud, Olivier
author Chabert, Adrien
author_facet Chabert, Adrien
Hamzeh Cognasse, Hind
Pozzetto, Bruno
Cognasse, Fabrice
Schattner, Mirta Ana
Gomez, Ricardo Martin
Garraud, Olivier
author_role author
author2 Hamzeh Cognasse, Hind
Pozzetto, Bruno
Cognasse, Fabrice
Schattner, Mirta Ana
Gomez, Ricardo Martin
Garraud, Olivier
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv HEMOSTASIS
INFECTION
PLATELETS
RECEPTORS
VIRUSES
topic HEMOSTASIS
INFECTION
PLATELETS
RECEPTORS
VIRUSES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infectious ones. Platelets express pathogen recognition receptors that can sense bacterial and viral moieties. Besides, several molecules that bind epithelial or sub-endothelial molecules and, so forth, are involved in hemostasis, happen to be able to ligate viral determinants, making platelets capable of either binding viruses or even to be infected by some of them. Further, as platelets express both Fc-receptors for Ig and complement receptors, they also bind occasionally virus-Ig or virus-Ig-complement immune complexes. Interplays of viruses with platelets are very complex and viral infections often interfere with platelet number and functions. Through a few instances of viral infections, the present review aims at presenting some of the most important interactions from pathophysiological and clinical points of view, which are observed between human viruses and platelets.
Fil: Chabert, Adrien. Universite Lyon 2; Francia
Fil: Hamzeh Cognasse, Hind. Universite Lyon 2; Francia
Fil: Pozzetto, Bruno. Universite Lyon 2; Francia
Fil: Cognasse, Fabrice. Universite Lyon 2; Francia
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Garraud, Olivier. Universite Lyon 2; Francia
description Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infectious ones. Platelets express pathogen recognition receptors that can sense bacterial and viral moieties. Besides, several molecules that bind epithelial or sub-endothelial molecules and, so forth, are involved in hemostasis, happen to be able to ligate viral determinants, making platelets capable of either binding viruses or even to be infected by some of them. Further, as platelets express both Fc-receptors for Ig and complement receptors, they also bind occasionally virus-Ig or virus-Ig-complement immune complexes. Interplays of viruses with platelets are very complex and viral infections often interfere with platelet number and functions. Through a few instances of viral infections, the present review aims at presenting some of the most important interactions from pathophysiological and clinical points of view, which are observed between human viruses and platelets.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38423
Chabert, Adrien; Hamzeh Cognasse, Hind; Pozzetto, Bruno; Cognasse, Fabrice; Schattner, Mirta Ana; et al.; Human platelets and their capacity of binding viruses: Meaning and challenges?; BioMed Central; BMC Immunology; 16; 1; 4-2015; 1-8
1471-2172
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38423
identifier_str_mv Chabert, Adrien; Hamzeh Cognasse, Hind; Pozzetto, Bruno; Cognasse, Fabrice; Schattner, Mirta Ana; et al.; Human platelets and their capacity of binding viruses: Meaning and challenges?; BioMed Central; BMC Immunology; 16; 1; 4-2015; 1-8
1471-2172
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s12865-015-0092-1
info:eu-repo/semantics/altIdentifier/url/https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-015-0092-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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