Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant

Autores
Porto, Patricia Inés; García, Silvia Inés; Dieuzeide, Guillermo; González, Claudio; Landa, Maria Silvina; Pirola, Carlos Jose
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Obesity and hypertension are increasing medical problems in adolescents. We evaluated the association between being overweight-particularly abdominal fat-and having hypertension and assessed the contribution of the Trp64Arg β3-adrenergic receptor gene variant. In a population-based study, we determined family history, anthropometric variables, and arterial blood pressure of 934 high school students, out of whom we selected 121 normotensive and 54 hypertensive students. Biochemical measurements included circulating renin and angiotensin-converting enzyme activities, leptin, glucose, insulin and lipid levels, and β3-adrenergic receptor genotypes. We used Mann-Whitney U test, χ2-test, and Spearman rank-order correlation. In the total population, hypertension prevalence increased across the entire range of body mass index (BMI) percentiles. In the sample, hypertensive students showed higher BMI, waist-to-hip ratio, triglycerides, and insulin resistance and lower HDL-cholesterol than normotensive students did. Age- and sex-adjusted systolic arterial blood pressure was correlated with BMI, waist-to-hip ratio, insulin resistance, and leptin. Leptin was correlated with BMI and homeostasis model assessment method. We found no association among hypertension, BMI, and leptin levels with β3-adrenergic receptor genotypes. Especially in girls, the waist-to-hip ratio was, however, suggestively higher in Arg64 variant carriers than in noncarriers, independent of hypertension. In fact, there was a significantly (p < 0.01) higher frequency of carriers of the Arg64 variant across the waist-to-hip ratio quartiles. In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the β3-adrenergic receptor gene may favor the central adiposity gain.
Fil: Porto, Patricia Inés. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: García, Silvia Inés. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Dieuzeide, Guillermo. Caidem; Argentina
Fil: González, Claudio. Universidad de Buenos Aires; Argentina
Fil: Landa, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
TRP64ARG
ADRB3
HYPERTENSION
ADOLESCENTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/217958
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/217958
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variantPorto, Patricia InésGarcía, Silvia InésDieuzeide, GuillermoGonzález, ClaudioLanda, Maria SilvinaPirola, Carlos JoseTRP64ARGADRB3HYPERTENSIONADOLESCENTShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Obesity and hypertension are increasing medical problems in adolescents. We evaluated the association between being overweight-particularly abdominal fat-and having hypertension and assessed the contribution of the Trp64Arg β3-adrenergic receptor gene variant. In a population-based study, we determined family history, anthropometric variables, and arterial blood pressure of 934 high school students, out of whom we selected 121 normotensive and 54 hypertensive students. Biochemical measurements included circulating renin and angiotensin-converting enzyme activities, leptin, glucose, insulin and lipid levels, and β3-adrenergic receptor genotypes. We used Mann-Whitney U test, χ2-test, and Spearman rank-order correlation. In the total population, hypertension prevalence increased across the entire range of body mass index (BMI) percentiles. In the sample, hypertensive students showed higher BMI, waist-to-hip ratio, triglycerides, and insulin resistance and lower HDL-cholesterol than normotensive students did. Age- and sex-adjusted systolic arterial blood pressure was correlated with BMI, waist-to-hip ratio, insulin resistance, and leptin. Leptin was correlated with BMI and homeostasis model assessment method. We found no association among hypertension, BMI, and leptin levels with β3-adrenergic receptor genotypes. Especially in girls, the waist-to-hip ratio was, however, suggestively higher in Arg64 variant carriers than in noncarriers, independent of hypertension. In fact, there was a significantly (p < 0.01) higher frequency of carriers of the Arg64 variant across the waist-to-hip ratio quartiles. In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the β3-adrenergic receptor gene may favor the central adiposity gain.Fil: Porto, Patricia Inés. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: García, Silvia Inés. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Dieuzeide, Guillermo. Caidem; ArgentinaFil: González, Claudio. Universidad de Buenos Aires; ArgentinaFil: Landa, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaInternational Pediatric Research Foundation2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217958Porto, Patricia Inés; García, Silvia Inés; Dieuzeide, Guillermo; González, Claudio; Landa, Maria Silvina; et al.; Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant; International Pediatric Research Foundation; Pediatric Research; 55; 5; 12-2004; 836-8410031-3998CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1203/01.PDR.0000119367.21770.D7info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/pr2004127info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:26Zoai:ri.conicet.gov.ar:11336/217958instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:26.332CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
title Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
spellingShingle Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
Porto, Patricia Inés
TRP64ARG
ADRB3
HYPERTENSION
ADOLESCENTS
title_short Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
title_full Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
title_fullStr Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
title_full_unstemmed Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
title_sort Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant
dc.creator.none.fl_str_mv Porto, Patricia Inés
García, Silvia Inés
Dieuzeide, Guillermo
González, Claudio
Landa, Maria Silvina
Pirola, Carlos Jose
author Porto, Patricia Inés
author_facet Porto, Patricia Inés
García, Silvia Inés
Dieuzeide, Guillermo
González, Claudio
Landa, Maria Silvina
Pirola, Carlos Jose
author_role author
author2 García, Silvia Inés
Dieuzeide, Guillermo
González, Claudio
Landa, Maria Silvina
Pirola, Carlos Jose
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv TRP64ARG
ADRB3
HYPERTENSION
ADOLESCENTS
topic TRP64ARG
ADRB3
HYPERTENSION
ADOLESCENTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Obesity and hypertension are increasing medical problems in adolescents. We evaluated the association between being overweight-particularly abdominal fat-and having hypertension and assessed the contribution of the Trp64Arg β3-adrenergic receptor gene variant. In a population-based study, we determined family history, anthropometric variables, and arterial blood pressure of 934 high school students, out of whom we selected 121 normotensive and 54 hypertensive students. Biochemical measurements included circulating renin and angiotensin-converting enzyme activities, leptin, glucose, insulin and lipid levels, and β3-adrenergic receptor genotypes. We used Mann-Whitney U test, χ2-test, and Spearman rank-order correlation. In the total population, hypertension prevalence increased across the entire range of body mass index (BMI) percentiles. In the sample, hypertensive students showed higher BMI, waist-to-hip ratio, triglycerides, and insulin resistance and lower HDL-cholesterol than normotensive students did. Age- and sex-adjusted systolic arterial blood pressure was correlated with BMI, waist-to-hip ratio, insulin resistance, and leptin. Leptin was correlated with BMI and homeostasis model assessment method. We found no association among hypertension, BMI, and leptin levels with β3-adrenergic receptor genotypes. Especially in girls, the waist-to-hip ratio was, however, suggestively higher in Arg64 variant carriers than in noncarriers, independent of hypertension. In fact, there was a significantly (p < 0.01) higher frequency of carriers of the Arg64 variant across the waist-to-hip ratio quartiles. In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the β3-adrenergic receptor gene may favor the central adiposity gain.
Fil: Porto, Patricia Inés. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: García, Silvia Inés. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Dieuzeide, Guillermo. Caidem; Argentina
Fil: González, Claudio. Universidad de Buenos Aires; Argentina
Fil: Landa, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Obesity and hypertension are increasing medical problems in adolescents. We evaluated the association between being overweight-particularly abdominal fat-and having hypertension and assessed the contribution of the Trp64Arg β3-adrenergic receptor gene variant. In a population-based study, we determined family history, anthropometric variables, and arterial blood pressure of 934 high school students, out of whom we selected 121 normotensive and 54 hypertensive students. Biochemical measurements included circulating renin and angiotensin-converting enzyme activities, leptin, glucose, insulin and lipid levels, and β3-adrenergic receptor genotypes. We used Mann-Whitney U test, χ2-test, and Spearman rank-order correlation. In the total population, hypertension prevalence increased across the entire range of body mass index (BMI) percentiles. In the sample, hypertensive students showed higher BMI, waist-to-hip ratio, triglycerides, and insulin resistance and lower HDL-cholesterol than normotensive students did. Age- and sex-adjusted systolic arterial blood pressure was correlated with BMI, waist-to-hip ratio, insulin resistance, and leptin. Leptin was correlated with BMI and homeostasis model assessment method. We found no association among hypertension, BMI, and leptin levels with β3-adrenergic receptor genotypes. Especially in girls, the waist-to-hip ratio was, however, suggestively higher in Arg64 variant carriers than in noncarriers, independent of hypertension. In fact, there was a significantly (p < 0.01) higher frequency of carriers of the Arg64 variant across the waist-to-hip ratio quartiles. In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the β3-adrenergic receptor gene may favor the central adiposity gain.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/217958
Porto, Patricia Inés; García, Silvia Inés; Dieuzeide, Guillermo; González, Claudio; Landa, Maria Silvina; et al.; Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant; International Pediatric Research Foundation; Pediatric Research; 55; 5; 12-2004; 836-841
0031-3998
CONICET Digital
CONICET
url http://hdl.handle.net/11336/217958
identifier_str_mv Porto, Patricia Inés; García, Silvia Inés; Dieuzeide, Guillermo; González, Claudio; Landa, Maria Silvina; et al.; Clinical features of the metabolic syndrome in adolescents: minor role of the Trp64Arg β3 -adrenergic receptor gene variant; International Pediatric Research Foundation; Pediatric Research; 55; 5; 12-2004; 836-841
0031-3998
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1203/01.PDR.0000119367.21770.D7
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/pr2004127
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Pediatric Research Foundation
publisher.none.fl_str_mv International Pediatric Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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