Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma

Autores
Siroski, Pablo Ariel; Merchant, Mark E.; Poletta, Gisela Laura; Larriera, Alejandro; Ortega, Hugo Hector
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reptiles proved to have a versatile and efficient nonspecific immune system adapted to the environment where they commonly live. Phospholipase A2 (PLA2) is important hydrolytic enzyme involved in the regulation of specific types of messengers with significant roles in the innate immune response. A number of agents that exert effects on cellular receptors emit a series of signals leading to an increased activity of PLA2. Phospholipase A2 has been identified and characterized in temperature, plasma concentration and kinetic dependence in two species of caiman. The results of these studies suggest that the high PLA2 activities exhibit in caiman plasma may be an important component of a well-developed innate immunity. Based in the knowledge of their properties, this powerful immunologic component should be evaluated as a possible application in the veterinary or even human therapeutic industry. Besides, it is another reason to consider these animals as excellent models to study immune phylogenetic mechanisms.
Fil: Siroski, Pablo Ariel. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Departamento de Cs.naturales. Laboratorio de Zoologia Aplicada: Anexo Vertebrados (fhuc-unl/maspyma); Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina
Fil: Merchant, Mark E.. McNeese State University. Department of Chemistry; Estados Unidos
Fil: Poletta, Gisela Laura. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Catedra de Toxicologia y Bioquimica Legal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Larriera, Alejandro. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Departamento de Cs.naturales. Laboratorio de Zoologia Aplicada: Anexo Vertebrados (fhuc-unl/maspyma); Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina
Materia
Phospholipases
Crocodilians
Immune System
Innate Immunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6434
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasmaSiroski, Pablo ArielMerchant, Mark E.Poletta, Gisela LauraLarriera, AlejandroOrtega, Hugo HectorPhospholipasesCrocodiliansImmune SystemInnate Immunityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Reptiles proved to have a versatile and efficient nonspecific immune system adapted to the environment where they commonly live. Phospholipase A2 (PLA2) is important hydrolytic enzyme involved in the regulation of specific types of messengers with significant roles in the innate immune response. A number of agents that exert effects on cellular receptors emit a series of signals leading to an increased activity of PLA2. Phospholipase A2 has been identified and characterized in temperature, plasma concentration and kinetic dependence in two species of caiman. The results of these studies suggest that the high PLA2 activities exhibit in caiman plasma may be an important component of a well-developed innate immunity. Based in the knowledge of their properties, this powerful immunologic component should be evaluated as a possible application in the veterinary or even human therapeutic industry. Besides, it is another reason to consider these animals as excellent models to study immune phylogenetic mechanisms.Fil: Siroski, Pablo Ariel. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Departamento de Cs.naturales. Laboratorio de Zoologia Aplicada: Anexo Vertebrados (fhuc-unl/maspyma); Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; ArgentinaFil: Merchant, Mark E.. McNeese State University. Department of Chemistry; Estados UnidosFil: Poletta, Gisela Laura. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Catedra de Toxicologia y Bioquimica Legal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Larriera, Alejandro. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Departamento de Cs.naturales. Laboratorio de Zoologia Aplicada: Anexo Vertebrados (fhuc-unl/maspyma); ArgentinaFil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; ArgentinaZoological Society of Japan2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6434Siroski, Pablo Ariel; Merchant, Mark E.; Poletta, Gisela Laura; Larriera, Alejandro; Ortega, Hugo Hector; Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma; Zoological Society of Japan; Zoological Science; 30; 1; 3-2013; 35-410289-0003enginfo:eu-repo/semantics/altIdentifier/url/http://www.bioone.org/doi/abs/10.2108/zsj.30.35?journalCode=jzooinfo:eu-repo/semantics/altIdentifier/doi/10.2108/zsj.30.35info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:38Zoai:ri.conicet.gov.ar:11336/6434instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:38.808CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
title Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
spellingShingle Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
Siroski, Pablo Ariel
Phospholipases
Crocodilians
Immune System
Innate Immunity
title_short Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
title_full Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
title_fullStr Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
title_full_unstemmed Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
title_sort Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma
dc.creator.none.fl_str_mv Siroski, Pablo Ariel
Merchant, Mark E.
Poletta, Gisela Laura
Larriera, Alejandro
Ortega, Hugo Hector
author Siroski, Pablo Ariel
author_facet Siroski, Pablo Ariel
Merchant, Mark E.
Poletta, Gisela Laura
Larriera, Alejandro
Ortega, Hugo Hector
author_role author
author2 Merchant, Mark E.
Poletta, Gisela Laura
Larriera, Alejandro
Ortega, Hugo Hector
author2_role author
author
author
author
dc.subject.none.fl_str_mv Phospholipases
Crocodilians
Immune System
Innate Immunity
topic Phospholipases
Crocodilians
Immune System
Innate Immunity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Reptiles proved to have a versatile and efficient nonspecific immune system adapted to the environment where they commonly live. Phospholipase A2 (PLA2) is important hydrolytic enzyme involved in the regulation of specific types of messengers with significant roles in the innate immune response. A number of agents that exert effects on cellular receptors emit a series of signals leading to an increased activity of PLA2. Phospholipase A2 has been identified and characterized in temperature, plasma concentration and kinetic dependence in two species of caiman. The results of these studies suggest that the high PLA2 activities exhibit in caiman plasma may be an important component of a well-developed innate immunity. Based in the knowledge of their properties, this powerful immunologic component should be evaluated as a possible application in the veterinary or even human therapeutic industry. Besides, it is another reason to consider these animals as excellent models to study immune phylogenetic mechanisms.
Fil: Siroski, Pablo Ariel. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Departamento de Cs.naturales. Laboratorio de Zoologia Aplicada: Anexo Vertebrados (fhuc-unl/maspyma); Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina
Fil: Merchant, Mark E.. McNeese State University. Department of Chemistry; Estados Unidos
Fil: Poletta, Gisela Laura. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Catedra de Toxicologia y Bioquimica Legal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Larriera, Alejandro. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Departamento de Cs.naturales. Laboratorio de Zoologia Aplicada: Anexo Vertebrados (fhuc-unl/maspyma); Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina
description Reptiles proved to have a versatile and efficient nonspecific immune system adapted to the environment where they commonly live. Phospholipase A2 (PLA2) is important hydrolytic enzyme involved in the regulation of specific types of messengers with significant roles in the innate immune response. A number of agents that exert effects on cellular receptors emit a series of signals leading to an increased activity of PLA2. Phospholipase A2 has been identified and characterized in temperature, plasma concentration and kinetic dependence in two species of caiman. The results of these studies suggest that the high PLA2 activities exhibit in caiman plasma may be an important component of a well-developed innate immunity. Based in the knowledge of their properties, this powerful immunologic component should be evaluated as a possible application in the veterinary or even human therapeutic industry. Besides, it is another reason to consider these animals as excellent models to study immune phylogenetic mechanisms.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6434
Siroski, Pablo Ariel; Merchant, Mark E.; Poletta, Gisela Laura; Larriera, Alejandro; Ortega, Hugo Hector; Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma; Zoological Society of Japan; Zoological Science; 30; 1; 3-2013; 35-41
0289-0003
url http://hdl.handle.net/11336/6434
identifier_str_mv Siroski, Pablo Ariel; Merchant, Mark E.; Poletta, Gisela Laura; Larriera, Alejandro; Ortega, Hugo Hector; Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma; Zoological Society of Japan; Zoological Science; 30; 1; 3-2013; 35-41
0289-0003
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.bioone.org/doi/abs/10.2108/zsj.30.35?journalCode=jzoo
info:eu-repo/semantics/altIdentifier/doi/10.2108/zsj.30.35
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Zoological Society of Japan
publisher.none.fl_str_mv Zoological Society of Japan
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844612997456068608
score 13.070432

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